593-29-3Relevant articles and documents
Fatty acid potassium had beneficial bactericidal effects and removed Staphylococcus aureus biofilms while exhibiting reduced cytotoxicity towards mouse fibroblasts and human keratinocytes
Kawahara, Takayoshi,Takita, Miki,Masunaga, Akihiro,Morita, Hayato,Tsukatani, Tadayuki,Nakazawa, Kohji,Go, Daisuke,Akita, Sadanori
, (2019/03/29)
Wounds frequently become infected or contaminated with bacteria. Potassium oleate (C18:1K), a type of fatty acid potassium, caused >4 log colony-forming unit (CFU)/mL reductions in the numbers of Staphylococcus aureus and Escherichia coli within 10 min and a >2 log CFU/mL reduction in the number of Clostridium difficile within 1 min. C18:1K (proportion removed: 90.3%) was significantly more effective at removing Staphylococcus aureus biofilms than the synthetic surfactant detergents sodium lauryl ether sulfate (SLES) (74.8%, p 0.01) and sodium lauryl sulfate (SLS) (78.0%, p 0.05). In the WST (water-soluble tetrazolium) assay, mouse fibroblasts (BALB/3T3 clone A31) in C18:1K (relative viability vs. control: 102.8%) demonstrated a significantly higher viability than those in SLES (30.1%) or SLS (18.1%, p 0.05). In a lactate dehydrogenase (LDH) leakage assay, C18:1K (relative leakage vs. control: 108.9%) was found to be associated with a significantly lower LDH leakage from mouse fibroblasts than SLES or SLS (720.6% and 523.4%, respectively; p 0.05). Potassium oleate demonstrated bactericidal effects against various species including Staphylococcus aureus, Escherichia coli, Bacillus cereus, and Clostridium difficile; removed significantly greater amounts of Staphylococcus aureus biofilm material than SLES and SLS; and maintained fibroblast viability; therefore, it might be useful for wound cleaning and peri-wound skin.
A method of manufacturing a sucrose stearate
-
Paragraph 0039, (2018/10/16)
PROBLEM TO BE SOLVED: monoester of a high rate of production of sucrose stearate selected. SOLUTION: the method of manufacturing the sucrose stearate, and sucrose and basic catalyst and a process for preparing an aqueous solution containing, in the process and the resultant aqueous solution, and an alkali metal salt of a fatty acid, and stearic acid ester is melted under a reduced pressure and agitating the mixture by heating and generating a sucrose stearate, is provided, the process of generating a sucrose stearate, mixture and removing water from the preceding stage of the process, the process of step of performing, after having poststage and, in the process of poststage, by microwave irradiation, and the mixture is heated so that the decomposition temperature of sucrose . Selected drawing: no
Facile and direct synthesis of symmetrical acid anhydrides using a newly prepared powerful and efficient mixed reagent
Rouhi-Saadabad, Hamed,Akhlaghinia, Batool
, p. 479 - 485 (2015/01/30)
An efficient mixed reagent for direct synthesis of symmetrical carboxylic anhydrides from carboxylic acids has been prepared. Carboxylic acids are converted to anhydrides using triphenylphosphine/ trichloroisocyanuric acid under mild reaction conditions at room temperature. Short reaction time, excellent yields of products, low cost, availability of reagents, simple experimental procedure, and easy work-up of the products are the main advantages of the presented method.
Removal of alkyl alkanesulfonate esters from alkanesulfonic acids and other organic media
-
Page/Page column 6, (2008/06/13)
Methods of removing alkyl alkanesulfonate esters from aqueous or anhydrous compositions are provided. The invention provides methods for the conversion of alkyl alkanesulfonate esters of the formula RSO3R′ to the corresponding acids of the formula RSO3H. The alkyl alkanesulfonate esters are present in an organic medium, which may contain significant amounts of water or which may be anhydrous or substantially anhydrous. In some embodiments, the invention provides methods for purifying aqueous or anhydrous alkanesulfonic acids by removing alkyl alkanesulfonate esters.
