597-64-8Relevant articles and documents
Reactivity of a tin(II) 1,3-benzodi(thiophosphinoyl)methanediide complex toward gallium, germanium, and zinc compounds
Yang, Yi-Fan,Ganguly, Rakesh,Li, Yongxin,So, Cheuk-Wai
, p. 2643 - 2648 (2013/06/27)
The reactivity of the tin(II) 1,3-benzodi(thiophosphinoyl)methanediide complex [{μ-1,3-C6H4(PhPS)2C}Sn]2 (1) toward GaCl3, GeCl4, and ZnEt2 is described. The reaction of 1 with 1.7 equiv of GeCl4 in CH 2Cl2 at room temperature afforded [1,3-C6H 4(PhPS)2C(GeCl3)SnCl]2 (2). Treatment of 1 with 1.7 equiv of ZnEt2 in refluxing toluene afforded [{1,3-C6H4(PhPS)2CSnEt2}(μ-ZnS)] 2 (3). Compound 1 also reacted with 1.7 equiv of GaCl3 in CH2Cl2 to afford [1,3-C6H4(PhPS) 2C(Sn)(GaCl3)] (4). Compounds 2-4 have been characterized by NMR spectroscopy and X-ray crystallography.
Continuous organomagnesium synthesis of organometallic compounds
Storozhenko,Grachev,Klochkov,Shiryaev
, p. 387 - 393 (2013/06/27)
Continuous organomagnesium synthesis of a number of organic derivatives of 14th group elements of the periodic table was examined in a column apparatus with an agitator. An effect of a molar ratio of reactants, temperature in a reaction zone, and other factors was studied on the yield and composition of the products.
The porphyrinogen-porphodimethene relationship leading to novel synthetic methodologies focused on the modification and functionalization of the porphyrinogen and porphodimethene skeletons
Bonomo, Lucia,Solari, Euro,Scopelliti, Rosario,Floriani, Carlo,Re, Nazzareno
, p. 5312 - 5326 (2007/10/03)
The general synthetic methods presented in this paper make available, on a preparative scale, unprecedented porphyrinogen-derived skeletons, including their functionalization at the meso positions. The stepwise dealkylation of meso-octaalkylporphyrinogen R8N4H4 [R = Et, 1; R = Bu(n), 2] was chemically, mechanistically, and structurally followed until the formation of porphomethene and porphodimethene derivatives 5-13, obtained with a sequential use of SnCl4. In particular, the porphodimethene derivative [(Et6N4)SnCl2], 9, was reductively transmetalated using Li metal to Et6N4Li2, 14, subsequently hydrolyzed to Et6N4H2, 15. The porphodimethene-nickel complex [(Et6N4)Ni], 16, was used for studying the reactivity and the ligand modification of the porphodimethene skeleton. The reactivity of 16 toward nucleophiles led to otherwise inaccessible meso- substituted-meso-functionalized porphyrinogens [(Et6N4R2)NiLi2], [R = H, 18; R = Bu(n), 19; R = CH2CN, 20], thus exemplifying a general methodology to meso-functionalized porphyrinogens. In addition, when [NMe2]- was used as the nucleophile, 16 was converted into mono- and bis- vinylideneporphyrinogen derivatives [{Et4(=CHMe)N4}NiLi], 21, and [{Et5(=CHMe)2N4}NiLi2], 22, through the intermediacy of meso- (dimethylamino)-porphyrinogens undergoing an α-H elimination from the meso positions. Such intermediates were isolated and characterized in the stepwise reaction of 14 with LiNMe2 leading to [{Et6(NMe2)2N4}Li4], 23, and [{Et5(NMe2)(=CHMe)N4}Li4], 25. Both compounds, as a function of the reaction solvent, undergo the thermal elimination of HNMe2 with the formation of [{Et4(=CHMe)2N4}Li4], 24, which is then protonated to [{Et4(=CHMe)2N4}H4], 27. Transmetalation from 23 to 24 can be used as the methodology for the synthesis of a remarkable variety of meso-substituted and functionalized porphyrinogen complexes. The deprotonation of 16 is reversible, therefore 22 and 23 can be protonated back to their starting materials. We took advantage of the nucleophilicity of the vinylidene carbon in 21 and 22 for establishing a general synthetic method to produce meso- functionalized porphodimethenes. This approach was exemplified with the alkylation and the benzoylation of 22 and 21 leading to [{Et4Pr(i)2N4}Ni], 28, [Et4{CH(Me)(PhCO)}2N4Ni], 29, and [Et5{CH(Me)(PhCO)}N4Ni], 30, respectively. Complex 21 displays a bifunctional behavior, as shown by the formation of 30, whereas in the reaction with LiBu, led to [{Et5(Bu(n))(=CHMe)N4}NiLi2], 31.
Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
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, (2008/06/13)
Synthetic nonpeptide and decapeptide LHRH antagonist analogs have a novel guanido-substituted, amidine, tertiary or quaternary amine water-soluble aminoacyl residue at position 6.
Nona and decapeptide analogs of LHRH useful as LHRH antagonists
-
, (2008/06/13)
Synthetic nonapeptide and decapeptide LHRH antagonist analogues having a halo lower alkyl guanadino-substituted amino acyl residue at position six are disclosed herein.
UNTERSUCHUNGEN ZUM ELEKTRONISCHEN EINFLUSS VON ORGANYLLIGANDEN.IV. 13-NMR-SPEKTROSKOPISCHE UNTERSUCHUNG DER GEGENSEITIGEN BEEINFLUSSUNG VON ORGANYLLIGANDEN IN TRIETHYLZINNORGANYLVERBINDUNGEN
Steinborn, Dirk,Buthge, Michael,Taube, Rudolf,Radeglia, Reiner,Schlothauer, Klaus,Nowak, Karin
, p. 277 - 286 (2007/10/02)
By means of 13C NMR spectroscopy, the coupling constants 1J(119Sn-13CEt) of 18 compounds of the SnEt3R type (R = organo group) have been measured.These coupling constants have been shown to reflect the change induced by R in the s-content of the tin hybrid orbitals of the Sn-CEt bonds.The series of the influence of R obtained on the basis of the coupling constant mentioned as a parameter is compared with a trans-influence series of R obtained on organomercury compounds.Occurring differences are attributed to different modes of bonding of the group R at the central atom.
CATHODIC SYNTHESIS OF TETRAALKYLTIN COMPOUNDS.
Ulery
, p. 1474 - 1478 (2008/10/08)
Methyl bromide and allyl bromide are efficiently reduced at a tin electrode to form tetramethyl and tetraallyl tin. A variety of other bromides with appreciably more negative reduction potentials also produce tetra-substituted tin compounds but the yields are lower. At higher potentials, cathode disintegration is a consequence of the competitive reduction of the carrier electrolyte (Et//4N** plus Br**-).
