600-57-7

Basic information

• Product Name: 11BETA-HYDROXYPROGESTERONE
• Synonyms: 11-beta-hydroxy-pregn-4-ene-20-dione;11-beta-hydroxypregn-4-ene-3,20-dione;11-hydroxy-20-dion(11-beta)-pregn-4-ene-;21-deoxycorticosterone;HYDROXYPROGESTERONE, 11B-;4-PREGNEN-11BETA-3,20-DIONE;4-PREGNEN-11BETA-OL-3,20-DIONE;11B-HYDROXYPROGESTERONE
• CAS NO: 600-57-7
• Molecular Formula: C21H30O3
• Molecular Weight: 330.46
• EINECS: 209-995-8
• Product Categories: Steroids
• Mol File: 600-57-7.mol

Chemical Properties

• Melting Point: 181～184℃
• Boiling Point: 487.4 °C at 760 mmHg
• Flash Point: 262.7 °C
• Appearance: /
• Density: 1.15 g/cm³
• Vapor Pressure: 1.51E-11mmHg at 25°C
• Refractive Index: 1.557
• Storage Temp.: 2-8°C
• Solubility: Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly)
• PKA: 14.52±0.70(Predicted)
• Water Solubility: 30.84mg/L(37 oC)
• CAS DataBase Reference: 11BETA-HYDROXYPROGESTERONE(CAS DataBase Reference)
• NIST Chemistry Reference: 11BETA-HYDROXYPROGESTERONE(600-57-7)
• EPA Substance Registry System: 11BETA-HYDROXYPROGESTERONE(600-57-7)

Safety Data

• Hazardous Substances Data: 600-57-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
11BETA-HYDROXYPROGESTERONE is used as a pharmaceutical agent for managing various hormonal imbalances and conditions related to the reproductive system. It is particularly useful in inducing maturation and secretory activity of the uterine endothelium, which can be beneficial in treating certain menstrual disorders and fertility issues.
Used in Research and Development:
11BETA-HYDROXYPROGESTERONE is used as a research compound to study the effects of Progesterone and its derivatives on various physiological processes. It can help researchers understand the role of this hormone in the development and progression of breast cancer and other related conditions.
Used in Environmental Monitoring:
As a contaminant of emerging concern, 11BETA-HYDROXYPROGESTERONE is used in environmental monitoring programs to assess the presence and impact of this compound in water bodies and other ecosystems. This helps in identifying potential risks to human health and the environment and implementing appropriate measures to mitigate them.

InChI:InChI=1/C21H30O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h10,15-19,24H,4-9,11H2,1-3H3

Upstream product

• 110-86-1 pyridine 
• 67-66-3 chloroform 
• 50-22-6 Corticosterone 
• 98-59-9 p-toluenesulfonyl chloride 
• 57-83-0 progesterone 
• 2302-12-7 17-acetyl-10,13-dimethyl-1,6,7,8,9,10,12,13,14,15,16,17-dodecahydro-2H-cyclopenta[a]phenanthrene-3,11-dione-3,21-diethylene ketal 
• 58761-32-3 11β-Hydroxypregn-4-en-3,20-dion Bis-semicarbazon 
• 546-67-8 lead(IV) tetraacetate 
• 15807-40-6 20,20-ethanediyldioxy-5β-pregnane-3α,11β-diol 
• 3754-67-4 (8S,9S,10S,11S,13S,14S,17S)-10,13-dimethyl-17-(2-methyl-1,3-dioxolan-2-yl)hexadecahydrospiro[cyclopenta[a]phenanthrene-3,2′-[1,3]dioxolan]-11-ol 
• 80-75-1 11-alpha-hydroxyprogesterone 
• 55561-02-9 thiopivalic acid 
• 57524-89-7 hydrocortisone valerate 
• 55176-88-0 11β-hydroxy-5β-pregnane-3,20-dione 

Downstream Products

• 4224-37-7 11β-hydroxypregna-1,4-diene-3,20-dione 
• 516-15-4 11-Ketoprogesterone 
• 17652-16-3 pregna-4,9⁽¹¹⁾-diene-3,20-dione 
• 566-65-4 dihydroprogesterone 

Relevant articles and documents

Dehalogenation methodof 9-halogenated steroid compound and application

The invention provides a dehalogenation method of a 9-halogenated steroid compound and application, and relates to the technical field of chemical synthesis. The dehalogenation method of the 9-halogenated steroid compound comprises the following steps: reacting a compound I with a hydrogen donor and an azo radical initiator to obtain a 9-dehalogenated product compound II of the 9-halogenated steroid compound. According to the dehalogenation method of the 9-halogenated steroid compound, a hydrogen donor adopts one or a combination of more of hypophosphorous acid and hypophosphite, formic acid and formate, organic silicon hydride, hydrazine compounds or cyclohexene, and an initiator adopts an azo free radical initiator. Reagents such as chromium, divalent chromium salt, trivalent chromium salt or tributyltin hydride which are high in toxicity and cause serious pollution to the environment are not used in the reaction, the method is green and environmentally friendly, the synthesis process is simple, convenient and easy to implement, and the production applicability is improved.

Metal-Free Iodine-Mediated Deoxygenation of Alcohols in the Position α to Electron-Withdrawing Groups

The use of a substoichiometric amount of molecular iodine in the presence of PPh3 and pyridine effects a direct deoxygenation of primary and secondary alcohols in positions α to a variety of activating electron-withdrawing groups, including ketones, esters, amides, imides and nitrile groups.

Raw synthesis and mitochondrial function postischemic mitochondria diseases related to the lack or for use in new compd. 11β-hydroxysteroid

The present invention provides novel compounds of 112-hydroxy steroids and compositions and their application as pharmaceuticals for preventing or reversing injury to mitochondria, for treating or preventing diseases relating to mitochondrial dysfunction or depletion, and for inducing regeneration or restructuring of mitochondria as a means of treating diseases relating to abnormalities in mitochondrial structure and function in a human or animal subject. Also disclosed herein are methods for diagnosing injury to mitochondria and for diagnosing the success or failure of therapeutics designed to treat, prevent, or reverse injury to or depletion of mitochondria.

HYDROXYSTEROID COMPOUNDS, THEIR INTERMEDIATES, PROCESS OF PREPARATION, COMPOSITION AND USES THEREOF

The present invention relates to novel steroidal compounds of formula (I), process for preparation of the same and composition comprising these compounds.

Steroids esterified in position 17 and thioesterified in position 21, a process for preparing them and their use as medicaments

Compounds of formula: STR1 wherein A and B each represent, independently of each other, a straight-chained or branched alkyl group having from 1 to 6 carbon atoms or a phenyl group optionally mono- or polysubstituted by alkyl radicals having from 1 to 6 carbon atoms, alkoxy groups having from 1 to 6 carbon atoms or halogen, T and U, independently of each other, represent hydrogen atoms or together form a double bond, V is a hydrogen atom or a methyl group at the α-position, W is a hydrogen atom or a halogen atom at the α-position, X is a hydroxy group at the β-position and Y is a hydrogen atom or X and Y may together represent an oxygen atom, and Z1 is a hydrogen atom, a methyl group at the α- or β-position, while Z2 is a hydrogen atom, or Z1 and Z2 together form a methylene group. These compounds have anti-inflammatory activity.

REGENERATION OF KETONES FROM SEMICARBAZONES BY LEAD TETRA-ACETATE : A NOVEL PREPARATION OF 18-HYDROXYCORTICOSTERONE

Lead tetra-acetate in acetic acid has been used to cleave a 3-semicarbazone in a novel preparation of 18-hydroxycorticosrerone, designed to avoid strongly acidic conditions.