60546-62-5

Basic information

• Product Name: 6-BROMO-3,4-METHYLENEDIOXYBENZOIC ACID
• Synonyms: 6-BROMOBENZO(1,3)-DIOXOLE-5-CARBOXYLIC ACID;6-BROMO-3,4-METHYLENEDIOXYBENZOIC ACID;RARECHEM AL BE 0271;6-BROMO-1,3-BENZODIOXOLE-5-CARBOXYLIC ACID;6-bromobenzo[d][1,3]dioxole-5-carboxylic acid;1,3-Benzodioxole-5-carboxylic acid, 6-bromo-
• CAS NO: 60546-62-5
• Molecular Formula: C₈H₅BrO₄
• Molecular Weight: 245.03
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 60546-62-5.mol

Chemical Properties

• Melting Point: 200-204 °C
• Boiling Point: 358.9°Cat760mmHg
• Flash Point: 170.8°C
• Appearance: /
• Density: 1.894g/cm³
• Vapor Pressure: 8.93E-06mmHg at 25°C
• Refractive Index: 1.647
• PKA: 3.00±0.20(Predicted)
• CAS DataBase Reference: 6-BROMO-3,4-METHYLENEDIOXYBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-3,4-METHYLENEDIOXYBENZOIC ACID(60546-62-5)
• EPA Substance Registry System: 6-BROMO-3,4-METHYLENEDIOXYBENZOIC ACID(60546-62-5)

Safety Data

• Hazardous Substances Data: 60546-62-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-BROMO-3,4-METHYLENEDIOXYBENZOIC ACID is used as a building block for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, potentially offering novel therapeutic options for a range of medical conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 6-BROMO-3,4-METHYLENEDIOXYBENZOIC ACID serves as a crucial intermediate in the production of various agrochemicals. Its incorporation into these compounds can enhance their effectiveness in pest control and crop protection, contributing to increased agricultural productivity.
Used in Dye and Pigment Production:
6-BROMO-3,4-METHYLENEDIOXYBENZOIC ACID is utilized as an intermediate in the manufacturing process of dyes and pigments. Its chemical properties enable the creation of vibrant and stable colorants for use in various applications, including textiles, plastics, and printing inks.
Safety and Storage:
6-BROMO-3,4-METHYLENEDIOXYBENZOIC ACID should be handled and stored in a cool, dry, and well-ventilated area to ensure its stability and prevent degradation. Additionally, proper safety precautions, such as wearing protective gear and following established guidelines, are essential when working with this compound to minimize potential health and environmental risks.

InChI:InChI=1/C8H5BrO4/c9-5-2-7-6(12-3-13-7)1-4(5)8(10)11/h1-2H,3H2,(H,10,11)

Upstream product

• 128-08-5 N-Bromosuccinimide 
• 120-57-0 piperonal 
• 67-66-3 chloroform 
• 15930-53-7 6-bromo-3,4-methylenedioxybenzaldehyde 
• 107-03-9 1-thiopropane 
• 124-41-4 sodium methylate 

Downstream Products

• 61441-09-6 methyl 6-bromo-1,3-benzodioxole-5-carboxylate 
• 61203-47-2 2-bromo-4,5-dihydroxybenzoic acid 
• 7470-99-7 2-(3,4,5-Trimethoxybenzoyl)-4,5-(methylenedioxy)benzoic Acid 
• 148614-05-5 6-Bromo-benzo[1,3]dioxole-5-carboxylic acid ((1R,4R,5R,6S)-4-hydroxy-5,6-bis-methoxymethoxy-cyclohex-2-enyl)-amide 
• 137423-21-3 1L-(1,2,3/4)-4-<(6-Bromopiperonyloyl)amino>-1-O-(4-methoxybenzyl)-2,3-bis-O-(methoxymethyl)-5-cyclohexene-1,2,3-triol 
• 7168-93-6 6-methoxy-benzo[1,3]dioxole-5-carboxylic acid 
• 223138-59-8 N-benzyl-6-bromo-N-(4-methyloxazol-2-yl)-3,4-methylenedioxybenzamide 
• 52886-06-3 hippadine 
• 173424-92-5 4,4-dimethyl-2-(6-benzyloxy-2-methoxy-4,5-(methylenedioxy)phenyl)-2-oxazoline 
• 173424-95-8 1-Benzyl-7-[6-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-7-triisopropylsilanyloxy-benzo[1,3]dioxol-5-yl]-2,3-dihydro-1H-indole 
• 148517-63-9 4'-hydroxy-2-isopropenyl-4,5-(methylenedioxy)diphenylmethane 
• 148517-62-8 4'-hydroxy-2-(1-methoxy-1-methylethyl)-4,5-(methylenedioxy)diphenylmethane 
• 148517-76-4 Acetic acid 4-(6-isopropenyl-benzo[1,3]dioxol-5-ylmethyl)-phenyl ester 
• 148517-75-3 Acetic acid 4-[6-(1-methoxy-1-methyl-ethyl)-benzo[1,3]dioxol-5-ylmethyl]-phenyl ester 

Relevant articles and documents

Regioselective ring opening by propanethiolate of (methylenedioxy)benzenes with electron-withdrawing substituents

The ring opening reaction of (methylenedioxy)benzenes 1 with propanethiolate in DMF leads to products 2 and/or 3, depending on the nature of the electron-withdrawing substituent Z.

Cleavage of Methylenedioxy Ring. II. Cleavage with Sodium Phenoxide and Methoxide in Dimethyl Sulfoxide

Regioselective cleavage of the methylenedioxy ring in piperonals (1, 6, and 7) and 3,4-methylenedioxynitrobenzenes (8 and 9) by oxide ions in dimethyl sulfoxide was achieved: the 4-hydroxybenzene derivatives (2, 10-13, and 22) were obtained with the phenoxide ion, while the 3-hydroxybenzene derivatives (4, 18-21, 23, 26, and 29) were obtained with the methoxide or benzyloxide ion.Keywords - cleavage of methylenedioxy ring; regioselectivity; piperonals; 3,4-methylenedioxynitrobenzenes; sodium phenoxide; sodium methoxide; dimethyl sulfoxide; 3-hydroxybenzene derivatives; 4-hydroxybenzene derivatives; NMR spectra