608-35-5

Basic information

• Product Name: meso-2,3-Dibromosuccinic acid
• Synonyms: 2,3-Dibromo Dibutyric Acid;meso-2,3-Dibromosuccinic acid;Threo-2,3-Dibromo Dibutyric acid;Threo-2,3-Dibromobutanedioic acid
• CAS NO: 608-35-5
• Molecular Formula: C₄H₄Br₂O₄
• Molecular Weight: 275.88
• EINECS: 208-396-9
• Mol File: 608-35-5.mol

Chemical Properties

• Melting Point: 255-260℃
• Boiling Point: 262.4°C at 760 mmHg
• Flash Point: 112.5°C
• Appearance: /
• Vapor Pressure: 0.00323mmHg at 25°C
• Water Solubility: 20 g/L (17℃)
• CAS DataBase Reference: meso-2,3-Dibromosuccinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: meso-2,3-Dibromosuccinic acid(608-35-5)
• EPA Substance Registry System: meso-2,3-Dibromosuccinic acid(608-35-5)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S24/25:Avoid contact with skin and eyes.
• Hazardous Substances Data: 608-35-5(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
Meso-2,3-Dibromosuccinic acid is used as a reagent in organic synthesis for various reactions, including esterification and hydrolysis. Its unique properties contribute to the efficiency and selectivity of these reactions.
Used in Pharmaceutical Production:
Meso-2,3-Dibromosuccinic acid is utilized in the production of pharmaceuticals. Its presence in the synthesis process can enhance the properties of the final drug product, making it more effective or suitable for specific applications.
Used in Agrochemical Production:
Meso-2,3-Dibromosuccinic acid is also used in the production of agrochemicals. Its unique properties can contribute to the development of more effective and targeted agrochemicals for various agricultural applications.
Used in Fine Chemicals Production:
Meso-2,3-Dibromosuccinic acid is employed in the production of fine chemicals, where its unique properties can be leveraged to create high-quality specialty chemicals for various industries.

InChI:InChI=1/C4H4Br2O4/c5-1(3(7)8)2(6)4(9)10/h1-2H,(H,7,8)(H,9,10)/p-2/t1-,2+

Upstream product

• 110-17-8 (2E)-but-2-enedioic acid 
• 45669-18-9 1,2-Dibromosuccinic anhydride 
• 7732-18-5 water 
• 1113-59-3 bromopyruvic acid 
• 6915-18-0 2-butenedioic acid 
• 921-52-8 racem.-2,3-diamino-succinic acid 
• 948907-33-3 (2R,3R)-2,3-diaminosuccinic acid 

Downstream Products

• 644-80-4 cis-2-bromobutenedioic acid 
• 53079-45-1 racem-2,3-bis-benzylamino-succinic acid 
• 88393-56-0 N,N'-dibenzyltartramide 
• 51575-86-1 dimethyl 2,3-dibromobutane-1,4-dicarboxylate 
• 928-04-1 Dikaliumsalz von Acetylendicarbonsaeure 
• 142-45-0 Acetylenedicarboxylic acid 
• 110-17-8 (2E)-but-2-enedioic acid 
• 45669-18-9 1,2-Dibromosuccinic anhydride 
• 856196-55-9 2,3-dibromosuccinyl dichloride 
• 5892-21-7 calcium mesotartrate*3H₂O 
• 55645-40-4 (2R,3S)-2,3-bis(benzylamino)succinic acid 

Relevant articles and documents

Synthesis method of o-Dibromo compound

The present invention discloses a synthesis method of o-dibromo compounds, said synthesis method comprising the following steps: preparation of olefins, brominated salts and a mixed solution of bromate; to the mixed solution of dropwise addition of hydrochloric acid solution for reaction; to the end of the reaction, the extraction of o-dibromo compounds in the reaction product; the synthesis method to inexpensive brominated salts (industrial or recycled brominated salts) and bromate as a bromine source, enhance the full use of applicable resources; after the end of the reaction after a simple filtration treatment to obtain a sufficient purity of the product, It can reduce production costs; at the same time, facilitate the transportation and storage of raw materials, and improve the working environment. The synthesis method of the present invention is simple and easy to operate, high safety, small pollution, simple post-treatment, low production cost, product yield and purity can meet the production needs, is both cost advantages and safety and environmental advantages of the industrializable process.

Preparation method of butynedioic acid

The invention discloses a preparation method of butynedioic acid. The method comprises the following steps of: (1) firstly, carrying out water-free and oxygen-free treatment on a closed reaction kettle; (2) putting calcium carbide, a solvent, a catalyst and an auxiliary agent into the reaction kettle, introducing carbon dioxide into the reaction kettle, and heating and pressurizing for reaction; (3) separating the reacted mixture obtained in the step (2) to obtain a liquid mixture, and adding a KOH solution into the liquid mixture; stirring to separate out a white precipitate; and dissolving the white precipitate in hot water, acidifying with concentrated sulfuric acid, cooling, separating out the white precipitate, and filtering to obtain the product. The synthesis method disclosed by theinvention is relatively environment-friendly and low in production cost.

Preparation method of 1,3-dibenzyl-2-oxoimidazolidine-4,5-dicarboxylic acid

The invention relates to a preparation method of 1,3-dibenzyl-2-oxoimidazolidine-4,5-dicarboxylic acid, comprising the steps of subjecting fumaric acid, bromine and hydrobromic acid to additive reaction to generate meso-2,3-dDibromosuccinic acid, subjecting the meso-2,3-dDibromosuccinic acid, benzylamine and a strong base to aminating reaction to generate dibenzylamino salt, subjecting the dibenzylamino salt and triphosgene to cyclization to generate the 1,3-dibenzyl-2-oxoimidazolidine-4,5-dicarboxylic acid. The fumaric acid is subjected to addition, and then substitution and cyclization are performed to obtain the 1,3-dibenzyl-2-oxoimidazolidine-4,5-dicarboxylic acid, and detection shows that HPLC (high-performance liquid chromatography) content of the 1,3-dibenzyl-2-oxoimidazolidine-4,5-dicarboxylic acid may reach 98-99%. The preparation method has the advantages that hydrobromic acid is added for bromination additive reaction, the concentration and reaction temperature of the hydrobromic acid are optimized, and bromine loss is more reduced; amination mother liquid is used in amination, the cost is saved, and product yield is increased; in ring-closure reaction, pH and reaction product concentration are decreased, the yield of the 1,3-dibenzyl-2-oxoimidazolidine-4,5-dicarboxylic acid is increased greatly, and the quality of the 1,3-dibenzyl-2-oxoimidazolidine-4,5-dicarboxylic acid is improved; experiments verify that through process innovation, production cost is reduced greatly, production efficiency is improved, and the process is energy efficient and environmentally friendly.

Kinetic study of the Ce(III)-, Mn(II)-, or ferroin-catalyzed Belousov-Zhabotinsky reaction with pyruvic acid

Ce(III)-, Mn(II)-, or ferroin (Fe(phen)32+)-catalyzed reaction of bromate ion and pyruvic acid (PA) or its dimer exhibits oscillatory behavior. Both the open-chain dimer (parapyruvic acid, γ-methyl-γ-hydroxyl-α-keto-glutaric acid, DP

Synthesis of Pyrazinamide

The key intermediate, pyrazinoic acid (III) in the synthesis of pyrazinamide has been prepared starting from 2,3-dibromsuccinic acid.