6154-14-9 Usage
Description
N-chloromethanamine, also known as a methylamine dichloramine derivative, is a chemical compound with the potential to induce colitis in mice. It is characterized by its ability to cause inflammation in the colon, making it a significant compound for studying the mechanisms and treatments of colitis.
Uses
Used in Pharmaceutical Research:
N-chloromethanamine is used as a research tool for studying the pathophysiology of colitis. Its ability to induce colitis in mice makes it a valuable compound for understanding the underlying mechanisms of the disease and for testing potential therapeutic interventions.
Used in Drug Development:
N-chloromethanamine is used as a starting point for the development of new drugs targeting colitis. By understanding how this compound causes inflammation in the colon, researchers can design and synthesize new molecules with improved efficacy and reduced side effects.
Used in Toxicology Studies:
N-chloromethanamine is used as a model compound in toxicology studies to investigate the effects of chemicals on the gastrointestinal tract. This helps in assessing the potential risks and safety profiles of new drugs and chemicals before they are introduced into the market.
Check Digit Verification of cas no
The CAS Registry Mumber 6154-14-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,1,5 and 4 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 6154-14:
(6*6)+(5*1)+(4*5)+(3*4)+(2*1)+(1*4)=79
79 % 10 = 9
So 6154-14-9 is a valid CAS Registry Number.
InChI:InChI=1/CH4ClN/c1-3-2/h3H,1H3
6154-14-9Relevant articles and documents
Synthesis of the first representatives of 3-ethynyldiaziridines
Makhova, Nina N.,Kamalova, Nailya G.,Strelenko, Yurii A.
, p. 227 - 229 (2001)
1,2-Dimethyl-3-(3,3-diethoxypropyn-1-yl)- and 1,2-dimethyl-3-(3-hydroxymethyl-3-methylbutyn-1-yl)diaziridines have been synthesised by the interaction of 4,4-diethoxybutyn-2-al and 4-hydroxymethyl-4-methylpentyn-2-al, respectively, with equimolar amounts of MeNH2 and MeNHCl (or MeNHOSO3H) at pH 9.5-10; the use of an excess of an amine in reactions with 4,4-diethoxybutyn-2-al resulted in a mixture of isomeric 5(3)-diethoxymethyl-1-methylpyrazoles and a mixture of Z/E isomers of 1-cyano3,3-diethoxy-2-methylaminoprop-1-enes.
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Laughlin,R.G.
, p. 2651 - 2656 (1968)
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AGENTS FOR TREATING NEURODEGENERATIVE DISORDERS
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Page/Page column 24, (2013/08/28)
The present invention relates to compounds of formula I, use of these compounds to treat mental and neurological disorders, especially depressions and psychoses of different etiology and methods for their preparation. The compounds provided for the treatm
Synthesis of 4-aroyl-1,2,4-triazolidin-3-ones via ring extension in reactions of 1,2-di- and 1,2,3,3-tetraalkyldiaziridines with aroyl isocyanates
Shevtsov,Kuznetsov,Molotov,Lyssenko,Makhova
, p. 554 - 558 (2007/10/03)
Reactions of 1,2-di-and 1,2,3,3-tetraalkyldiaziridines with aroyl isocyanates involve opening of the diaziridine ring through cleavage of the C-N bond followed by cyclization of the zwitterionic intermediate into 4-aroyl-1,2,4-triazolidin-3-one derivative
