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6343-54-0

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6343-54-0 Usage

Description

N-Benzylformamide is an organic compound that serves as a valuable synthetic intermediate in the field of organic chemistry. It is characterized by its amide functional group and benzyl moiety, which contribute to its reactivity and potential applications in various chemical reactions and processes.

Uses

Used in Pharmaceutical Industry:
N-Benzylformamide is used as a synthetic intermediate for the preparation of thiadiazolidinone derivatives. These derivatives have potential applications as glycogen synthase kinase 3 (GSK-3) inhibitors, which are important targets for the development of drugs to treat various diseases, including neurodegenerative disorders and cancer.
Used in Antitubercular Drug Development:
N-Benzylformamide is also utilized in the synthesis of selective antitubercular agents. Tuberculosis is a significant global health concern, and the development of new and effective antitubercular drugs is crucial to combat drug-resistant strains and improve treatment outcomes.

Synthesis Reference(s)

Synthetic Communications, 13, p. 745, 1983 DOI: 10.1080/00397918308063704Synthesis, p. 510, 1987 DOI: 10.1055/s-1987-27987

Check Digit Verification of cas no

The CAS Registry Mumber 6343-54-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,4 and 3 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 6343-54:
(6*6)+(5*3)+(4*4)+(3*3)+(2*5)+(1*4)=90
90 % 10 = 0
So 6343-54-0 is a valid CAS Registry Number.
InChI:InChI=1/C8H9NO/c10-7-9-6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H,9,10)

6343-54-0 Well-known Company Product Price

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  • Alfa Aesar

  • (B23722)  N-Benzylformamide, 99%   

  • 6343-54-0

  • 5g

  • 217.0CNY

  • Detail
  • Alfa Aesar

  • (B23722)  N-Benzylformamide, 99%   

  • 6343-54-0

  • 25g

  • 802.0CNY

  • Detail
  • Alfa Aesar

  • (B23722)  N-Benzylformamide, 99%   

  • 6343-54-0

  • 100g

  • 2624.0CNY

  • Detail

6343-54-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name N-benzylformamide

1.2 Other means of identification

Product number -
Other names N-BENZYLFORMAMIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6343-54-0 SDS

6343-54-0Relevant articles and documents

A Mild and Efficient Preparation of cis-1,2-Diols from 1,2,4-Trioxanes

Jefford, Charles W.,Rossier, Jean-Claude,Boukouvalas, John

, p. 1593 - 1594 (1987)

3,3-Unsubstituted cis-fused bicyclic 1,2,4-trioxanes, on treatment with benzylamine, gave the corresponding cis-1,2-diols in 85-99percent yield.

A formylating agent by dehydration of the natural product DIMBOA

Hofmann, Angelika,Sicker, Dieter

, p. 1151 - 1153 (1999)

The natural aglucone 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one (DIMBOA, 1) of maize underwent spontaneous dehydration and rearrangement to form 3-formyl-6-methoxybenzoxazolin-2(3H)-one (FMBOA, 2) on reaction with N- ethoxycarbonyl-trichloroacetaldimine. Compound 2 was proven to be a reactive formyl donor toward N-, O-, and S-nucleophiles, which may be important in case 2 is formed under biological conditions.

Modulation by Amino Acids: Toward Superior Control in the Synthesis of Zirconium Metal–Organic Frameworks

Gutov, Oleksii V.,Molina, Sonia,Escudero-Adán, Eduardo C.,Shafir, Alexandr

, p. 13582 - 13587 (2016)

The synthesis of zirconium metal–organic frameworks (Zr MOFs) modulated by various amino acids, including l-proline, glycine, and l-phenylalanine, is shown to be a straightforward approach toward functional-group incorporation and particle-size control. High yields in Zr-MOF synthesis are achieved by employing 5 equivalents of the modulator at 120 °C. At lower temperatures, the method provides a series of Zr MOFs with increased particle size, including many suitable for single-crystal X-ray diffraction studies. Furthermore, amino acid modulators can be incorporated at defect sites in Zr MOFs with an amino acid/ligand ratio of up to 1:1, depending on the ligand structure and reaction conditions. The MOFs obtained through amino acid modulation exhibit an improved CO2-capture capacity relative to nonfunctionalized materials.

Highly Efficient and Selective N-Formylation of Amines with CO2 and H2 Catalyzed by Porous Organometallic Polymers

Shen, Yajing,Zheng, Qingshu,Chen, Zhe-Ning,Wen, Daheng,Clark, James H.,Xu, Xin,Tu, Tao

supporting information, p. 4125 - 4132 (2021/01/12)

The valorization of carbon dioxide (CO2) to fine chemicals is one of the most promising approaches for CO2 capture and utilization. Herein we demonstrated a series of porous organometallic polymers could be employed as highly efficient and recyclable catalysts for this purpose. Synergetic effects of specific surface area, iridium content, and CO2 adsorption capability are crucial to achieve excellent selectivity and yields towards N-formylation of diverse amines with CO2 and H2 under mild reaction conditions even at 20 ppm catalyst loading. Density functional theory calculations revealed not only a redox-neutral catalytic pathway but also a new plausible mechanism with the incorporation of the key intermediate formic acid via a proton-relay process. Remarkably, a record turnover number (TON=1.58×106) was achieved in the synthesis of N,N-dimethylformamide (DMF), and the solid catalysts can be reused up to 12 runs, highlighting their practical potential in industry.

Catalyst freeN-formylation of aromatic and aliphatic amines exploiting reductive formylation of CO2using NaBH4

Kumar, Arun,Kumar, Yashwant,Mahajan, Dinesh,Sharma, Nidhi,Sharma, Pankaj

, p. 25777 - 25787 (2021/08/05)

Herein, we report a sustainable approach forN-formylation of aromatic as well as aliphatic amines using sodium borohydride and carbon dioxide gas. The developed approach is catalyst free, and does not need pressure or a specialized reaction assembly. The reductive formylation of CO2with sodium borohydride generates formoxy borohydride speciesin situ, as confirmed by1H and11B NMR spectroscopy. Thein situformation of formoxy borohydride species is prominent in formamide based solvents and is critical for the success of theN-formylation reactions. The formoxy borohydride is also found to promote transamidation reactions as a competitive pathway along with reductive functionalization of CO2with amine leading toN-formylation of amines.

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