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6366-70-7

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  • China Largest factory Manufacturer Supply N6-Cbz-L-Lysine benzyl ester hydrochloride CAS 6366-70-7

    Cas No: 6366-70-7

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6366-70-7 Usage

Chemical Properties

White Solid

Uses

N6-Cbz-L-Lysine benzyl ester hydrochloride can be useful for the preparation of pseudopeptides as thrombolytic agents.

Check Digit Verification of cas no

The CAS Registry Mumber 6366-70-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,3,6 and 6 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 6366-70:
(6*6)+(5*3)+(4*6)+(3*6)+(2*7)+(1*0)=107
107 % 10 = 7
So 6366-70-7 is a valid CAS Registry Number.
InChI:InChI=1/C21H26N2O4/c22-19(20(24)26-15-17-9-3-1-4-10-17)13-7-8-14-23-21(25)27-16-18-11-5-2-6-12-18/h1-6,9-12,19H,7-8,13-16,22H2,(H,23,25)

6366-70-7 Well-known Company Product Price

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  • Alfa Aesar

  • (H63714)  Nepsilon-Benzyloxycarbonyl-L-lysine benzyl ester hydrochloride, 98%   

  • 6366-70-7

  • 1g

  • 260.0CNY

  • Detail
  • Alfa Aesar

  • (H63714)  Nepsilon-Benzyloxycarbonyl-L-lysine benzyl ester hydrochloride, 98%   

  • 6366-70-7

  • 5g

  • 1009.0CNY

  • Detail
  • Aldrich

  • (96880)  H-Lys(Z)-OBzlhydrochloride  ≥98.0% (TLC)

  • 6366-70-7

  • 96880-5G

  • 1,153.62CNY

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6366-70-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name N6-Cbz-L-lysine Benzyl Ester Hydrochloride

1.2 Other means of identification

Product number -
Other names N6-Carbobenzyloxy-L-lysine Benzyl Ester Hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6366-70-7 SDS

6366-70-7Relevant articles and documents

Synthesis of the Tripeptides Tyr-Thr-Lys Phosphorylated with Isopropyl Methyl- and (Deuteromethyl)phosphonochloridates as Reference Standards for the Analysis of Biomedical Samples

Rodin,Baygildiev,Krylov,Osipov,Krylov,Yashkir,Rybalchenko

, p. 2103 - 2107 (2019/11/29)

A procedure for the phosphorylation of the tripeptide Tyr-Thr-Lys with isopropyl methyl- or (deuteromethyl)phosphonochloridate is developed. The phosphorylated tripeptides are intended for use as reference standards in the analysis of blood samples of people suspected to have been exposed to acetylcholinesterase inhibitors. Conditions of hromatographic separation and purification of the synthesized compounds are determined and optimized, which ensures the preparation of high-purity phosphorylated tripeptides.

A class of novel carboline intercalators: Their synthesis, in vitro anti-proliferation, in vivo anti-tumor action, and 3D QSAR analysis

Wu, Jianhui,Li, Chunyu,Zhao, Ming,Wang, Wenjing,Wang, Yuji,Peng, Shiqi

experimental part, p. 6220 - 6229 (2010/10/04)

Based on DOCK scores 18 N-(3-benzyloxycarbonylcarboline-1-yl)ethylamino acid benzylesters (6a-r) were synthesized as anti-tumor agents. Their IC 50 values against five human carcinoma cell lines ranged from 11.1 μM to more than 100 μM. The in vivo assay identified five derivatives of them had no anti-tumor action, the anti-tumor activity of nine derivatives of them equaled that of cytarabine, and the anti-tumor activity of three derivatives of them was higher than that of cytarabine. The UV and fluorescence spectra, as well as the relative viscosity and melting temperature measurements of calf thymus DNA (CT DNA) with and without the representative compound suggested that DNA intercalation could be their action mechanism. The 3D QSAR analysis of N-(3-benzyloxycarbonylcarboline-1-yl)ethylamino acid benzylesters (6a-r) revealed that their in vivo anti-tumor activity significantly depends on the molecular electrostatic and steric fields of the side chain of the amino acid residue.

Granulopoiesis Inhibiting Factor: Synthesis and Biological Activity

Kulikov, S. V.,Leonova, E. B.,Kalinina, N. M.,Samartsev, M. A.,Bubnova, L. N.,et al.

, p. 362 - 369 (2007/10/02)

Three schemes of synthesis for pentapeptide Glp-Glu-Asp-Cys-Lys-OH were compared.Acetamidomethyl protection was used for the mercapto group of cysteine.For the same purpose, cystine was used as the starting compound for synthesis.The optimal method was shown to be the solid phase method with S-acetamidomethyl cysteine protection that can be removed by mercuric acetate before the cleavage of a peptide from a polymer.The stabilized peptide inhibits proliferation of bone marrow cells of patients with chronic myeloleukemia 5- to 20-fold and has a less pronounced effect (up to 2-fold inhibition) on peripheral blood cells.Thus, its application for the therapy of hemoblastoses is promising. Key words: granulopoiesis inhibiting factor, solid phase peptide synthesis, cysteine-containing pentapeptide

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