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65-23-6

65-23-6

Identification

  • Product Name:3,4-Pyridinedimethanol,5-hydroxy-6-methyl-

  • CAS Number: 65-23-6

  • EINECS:200-603-0

  • Molecular Weight:169.18

  • Molecular Formula: C8H11NO3

  • HS Code:29362500

  • Mol File:65-23-6.mol

Synonyms:Pyridoxol(8CI);2-Methyl-3-hydroxy-4,5-di(hydroxymethyl)pyridine;2-Methyl-4,5-bis(hydroxymethyl)-3-hydroxypyridine;5-Hydroxy-6-methyl-3,4-pyridinedimethanol;Adermin;Bezatin;Pirivitol;Pyridoxin;VB6;

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Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes: Xi:Irritant;

  • Signal Word:Warning

  • Hazard Statement:H315 Causes skin irritationH319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Absorption, Distribution and ExcretionThe B vitamins are readily absorbed from the gastrointestinal tract, except in malabsorption syndromes. Pyridoxine is absorbed mainly in the jejunum.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Pyridoxine hydrochloride preparations should be protected from light & stored in well-closed containers at a temperature < 40 degrees C, preferably between 15-30 degrees C; freezing of the injection should be avoided.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:Usbiological
  • Product Description:Pyridoxine
  • Packaging:250mg
  • Price:$ 305
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:Pyridoxine
  • Packaging:1g
  • Price:$ 55
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Pyridoxol (pyridoxine) vitaminB?baseEMPROVE?ESSENTIAL
  • Packaging:25 kg
  • Price:$ 44340
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Pyridoxol (pyridoxine) vitamin B? base EMPROVE? ESSENTIAL
  • Packaging:5012609025
  • Price:$ 42060
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Pyridoxol (pyridoxine) vitaminB?baseEMPROVE?ESSENTIAL
  • Packaging:1 kg
  • Price:$ 2110
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Pyridoxol (pyridoxine) vitamin B? base EMPROVE? ESSENTIAL
  • Packaging:5012601000
  • Price:$ 2000
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Pyridoxine ≥98%
  • Packaging:5g
  • Price:$ 59.9
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Pyridoxine ≥98%
  • Packaging:25g
  • Price:$ 102
  • Delivery:In stock
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  • Manufacture/Brand:Medical Isotopes, Inc.
  • Product Description:VitaminB6
  • Packaging:1 g
  • Price:$ 290
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:3-Hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine hydrochloride 95+%
  • Packaging:5g
  • Price:$ 54
  • Delivery:In stock
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Relevant articles and documentsAll total 21 Articles be found

Pyridoxamine, a scavenger agent of carbohydrates

Adrover, Miquel,Vilanova, Bartolome,Munoz, Francisco,Donoso, Josefa

, p. 154 - 167 (2007)

Pyridoxamine has been found to inhibit protein glycation and to avoid the formation of advanced glycation end-products (AGEs). One of the mechanisms by which pyridoxamine can inhibit glycation involves the scavenger of carbonyl groups with glycation capacity. In this work, we conducted a kinetic study of the reactions of pyridoxamine with various carbohydrates under physiological pH and temperature. The reactions involving hexoses were found to give a tricyclic compound (5) in addition to pyridoxal and pyridoxine. Such a tricyclic compound inhibits the Amadori rearrangement and the formation of other carbonyl compounds with glycating properties. The reactions involving pentoses gave compound 7 and pyridoxal - by transamination of the Schiff base. The transamination reaction enhances the inhibitory action of pyridoxamine. The formation rate constants for the Schiff base, k3, were found to be similar to those for the reactions of D-glucose with amino acids, which suggests competition between pyridoxamine and terminal amino residues in proteins for glycating sites in sugars. These constants are dependent on the electrophilic character of the carbonyl carbon in the carbohydrate.

Purification and characterization of pyridoxine 5′-phosphate phosphatase from Sinorhizobium meliloti

Tazoe, Masaaki,Ichikawa, Keiko,Hoshino, Tatsuo

, p. 2277 - 2284 (2005)

Here we report the purification and biochemical characterization of a pyridoxine 5′-phosphate phosphatase involved in the biosynthesis of pyridoxine in Sinorhizobium meliloti. The phosphatase was localized in the cytoplasm and purified to electrophoretic homogeneity by a combination of EDTA/lysozyme treatment and five chromatography steps. Gel-filtration chromatography with Sephacryl S-200 and SDS/PAGE demonstrated that the protein was a monomer with a molecular size of approximately 29kDa. The protein required divalent metal ions for pyridoxine 5′-phosphate phosphatase activity, and specifically catalyzed the removal of Pi from pyridoxine and pyridoxal 5′-phosphates at physiological pH (about 7.5). It was inactive on pyridoxamine 5′-phosphate and other physiologically important phosphorylated compounds. The enzyme had the same Michaelis constant (K m) of 385 μM for pyridoxine and pyridoxal 5′-phosphates, but its specific constant [maximum velocity (Vmax)/Km] was nearly 2.5 times higher for the former than for the latter.

Biosynthesis of vitamin B6 in Rhizobium: in vitro synthesis of pyridoxine from 1-deoxy-D-xylulose and 4-hydroxy-L-threonine.

Tazoe, Masaaki,Ichikawa, Keiko,Hoshino, Tatsuo

, p. 934 - 936 (2002)

Pyridoxine (vitamin B6) in Rhizobium is synthesized from 1-deoxy-D-xylulose and 4-hydroxy-L-threonine. To define the pathway enzymatically, we established an enzyme reaction system with a crude enzyme solution of R. meliloti IFO14782. The enzyme reaction system required NAD+, NADP+, and ATP as coenzymes, and differed from the E. coli enzyme reaction system comprising PdxA and PdxJ proteins, which requires only NAD+ for formation of pyridoxine 5'-phosphate from 1-deoxy-D-xylulose 5-phosphate and 4-(phosphohydroxy)-L-threonine.

Environmentally friendly preparation method for vitamin B6

-

, (2019/07/04)

The invention relates to an environmentally friendly preparation method for vitamin B6. The method comprises the following steps: carrying out a condensation reaction on a carbonyl compound and 2-cyano-2-cis-butene-1,4-diol which is used as a starting material, protecting hydroxyl groups to obtain 2,2-disubstituted-5-cyano-4,7-dihydro-1,3-dioxepine, carrying out a formylation reaction on the 2,2-disubstituted-5-cyano-4,7-dihydro-1,3-dioxepine, carbon monoxide and hydrogen to prepare 2,2-disubstituted-5-cyano-6-formyl-1,3-dioxetpin, condensing the 2,2-disubstituted-5-cyano-6-formyl-1,3-dioxetpin and 2-aminopropionate or its hydrochloride, and removing the carbonyl compound to prepare the vitamin B6. The method does not use a 4-methyl-5-alkoxyoxazole intermediate which is expensive and generates a large amount of wastewater in the production process, so the method has the advantages of environmentally friendly process, high reaction selectivity, high product purity, high atom economy, and suitableness for industrial production.

Preparation method of high content vitamin B6

-

Paragraph 0047-0048, (2019/07/16)

The invention relates to a preparation method of a high content vitamin B6. According to the method, 1,5-dihydro-3,3-disubstituent group-8-methyl-9-alkyl carbonyl oxypyrido [3,4-e]-1,3-dioxane is prepared by the Diels-Alder addition reaction, aromatization reaction and esterification reaction of 4-methyl-5-alkoxyl-oxazole and 2,2-disubstituent group-4,7-dihydro-1,3-dioxepine in the presence of ananhydride through the "one-pot method", and then vitamin B6 is prepared by deprotection. According to the method, the stability of the raw materials of 4-methyl-5-alkoxyl-oxazole and 2,2-disubstituentgroup-4,7-dihydro-1,3-dioxepine are ensured, the reaction is thorough, and the selectivity is high, so that the method provides guarantees for the preparation of high content medicinal vitamin B6.

Method for preparing vitamin B6 by reduction method

-

Paragraph 0020; 0023; 0032; 0033, (2018/09/08)

The invention discloses a method for preparing a vitamin B6 in a reduction manner. The method comprises the following steps of (a), dissolving 2-methyl-3-hydroxypyridine-4,5-diformate in a solvent, adding a weak reducer and an organic acid, raising a temperature to 40 to 90 DEG C, carrying out a reflux reaction for 2h to 5h, and cooling the temperature, so as to obtain a solution system; (b), adding hydrochloric acid into the solution system to regulate to be acidic, then adding sodium hydroxide to regulate to be alkaline, filtering, extracting filtrate, and introducing a HCl gas into an extract phase, so as to obtain a saturated solution; (c), standing the saturated solution at room temperature for devitrification, filtering, washing, oven-drying, recrystallizing and filtering, wherein inthe step (a), the weak reducer is sodium borohydride or potassium borohydride; the organic acid is one of formic acid, acetic acid, oxalic acid, trifluoroacetic acid, propionic acid, benzoic acid andtartaric acid. By the combination of the low-cost weak reducer sodium borohydride or potassium borohydride and the organic acid which are adopted by the method to prepare the vitamin B6, the ester isjointly reduced, and a reaction condition is mild.

Effect of structure of nucleophile and substrate on the quaternization of heterocyclic amines

Zhuravlev,Verolainen,Voronchikhina

experimental part, p. 1025 - 1028 (2011/01/11)

The influence of the nature of the quaternizing agent and substrate on the quaternization of heterocyclic amines, derivatives of pyridine, ss-picoline, nicotinamide, pyridoxine, was studied. The synthesized compounds were characterized by IR spectroscopy and elemental analysis. The conclusions were made about the effect of the structure of nucleophile and substrate on the process of quaternization reaction. Pleiades Publishing, Ltd., 2010.

Process route upstream and downstream products

Process route

5-hydroxy-6-methylpyridine-3,4-dicarboxylic acid diethyl ester
2397-71-9

5-hydroxy-6-methylpyridine-3,4-dicarboxylic acid diethyl ester

5-hydroxy-6-methyl-3,4-pyridinedimethanol
65-23-6

5-hydroxy-6-methyl-3,4-pyridinedimethanol

Conditions
Conditions Yield
With sodium tetrahydroborate; acetic acid; In tetrahydrofuran; at 30 - 60 ℃; for 3h; Solvent;
94%
With Me3SiH(OEt)2; tetrabutyl ammonium fluoride; In 1,4-dioxane; at 100 ℃; for 24h;
butyl 2-methyl-3-hydroxypyridine-4,5-dicarboxylate

butyl 2-methyl-3-hydroxypyridine-4,5-dicarboxylate

5-hydroxy-6-methyl-3,4-pyridinedimethanol
65-23-6

5-hydroxy-6-methyl-3,4-pyridinedimethanol

Conditions
Conditions Yield
With sodium tetrahydroborate; benzoic acid; In tetrahydrofuran; at 40 - 60 ℃; for 2h; Reagent/catalyst; Solvent; Temperature;
95%
propyl 2-methyl-3-hydroxypyridine-4,5-dicarboxylate

propyl 2-methyl-3-hydroxypyridine-4,5-dicarboxylate

5-hydroxy-6-methyl-3,4-pyridinedimethanol
65-23-6

5-hydroxy-6-methyl-3,4-pyridinedimethanol

Conditions
Conditions Yield
With sodium tetrahydroborate; oxalic acid; In 2-methyltetrahydrofuran; at 30 - 70 ℃; for 4h;
90%
C<sub>12</sub>H<sub>17</sub>NO<sub>3</sub>

C12H17NO3

5-hydroxy-6-methyl-3,4-pyridinedimethanol
65-23-6

5-hydroxy-6-methyl-3,4-pyridinedimethanol

Conditions
Conditions Yield
With hydrogenchloride; In water; at 50 ℃; for 4h; Green chemistry;
93.7%
4,5'-O-isobutylidenepyridoxine
1622-67-9

4,5'-O-isobutylidenepyridoxine

5-hydroxy-6-methyl-3,4-pyridinedimethanol
65-23-6

5-hydroxy-6-methyl-3,4-pyridinedimethanol

Conditions
Conditions Yield
With hydrogenchloride; In water; at 45 ℃; for 4h; Green chemistry;
94.7%
C<sub>12</sub>H<sub>17</sub>NO<sub>3</sub>

C12H17NO3

5-hydroxy-6-methyl-3,4-pyridinedimethanol
65-23-6

5-hydroxy-6-methyl-3,4-pyridinedimethanol

Conditions
Conditions Yield
With hydrogenchloride; In water; at 55 ℃; for 4h; Green chemistry;
86.4%
8-methyl-3-propyl-1H,3H,5H-[1,3]dioxepino[5,6-c]pyridin-9-yl acetate

8-methyl-3-propyl-1H,3H,5H-[1,3]dioxepino[5,6-c]pyridin-9-yl acetate

5-hydroxy-6-methyl-3,4-pyridinedimethanol
65-23-6

5-hydroxy-6-methyl-3,4-pyridinedimethanol

Conditions
Conditions Yield
With hydrogenchloride; In ethanol; for 5h; Reflux;
95.9%
8-methyl-3-(propan-2-yl)-1H,3H,5H-[1,3]dioxepino[5,6-c]pyridin-9-yl acetate
92671-67-5

8-methyl-3-(propan-2-yl)-1H,3H,5H-[1,3]dioxepino[5,6-c]pyridin-9-yl acetate

5-hydroxy-6-methyl-3,4-pyridinedimethanol
65-23-6

5-hydroxy-6-methyl-3,4-pyridinedimethanol

Conditions
Conditions Yield
With hydrogenchloride; In ethanol; for 6h; Reflux;
96.8%
amyl 2-methyl-3-hydroxypyridine-4,5-dicarboxylate

amyl 2-methyl-3-hydroxypyridine-4,5-dicarboxylate

5-hydroxy-6-methyl-3,4-pyridinedimethanol
65-23-6

5-hydroxy-6-methyl-3,4-pyridinedimethanol

Conditions
Conditions Yield
With sodium tetrahydroborate; trifluoroacetic acid; In tetrahydrofuran; at 90 ℃; for 3h;
5-hydroxy-6-methyl-3,4-pyridinedimethanol
65-23-6

5-hydroxy-6-methyl-3,4-pyridinedimethanol

Conditions
Conditions Yield
With hydrogenchloride; water; at 155 - 160 ℃;

Global suppliers and manufacturers

Global( 176) Suppliers
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  • DB BIOTECH CO., LTD
  • Business Type:Trading Company
  • Contact Tel:86--1829 2989 553
  • Emails:info@db-biotech.com
  • Main Products:87
  • Country:China (Mainland)
  • Simagchem Corporation
  • Business Type:Manufacturers
  • Contact Tel:+86-592-2680277
  • Emails:sale@simagchem.com
  • Main Products:110
  • Country:China (Mainland)
  • Kono Chem Co.,Ltd
  • Business Type:Other
  • Contact Tel:86-29-86107037-8015
  • Emails:info@konochemical.com
  • Main Products:82
  • Country:China (Mainland)
  • Chemwill Asia Co., Ltd.
  • Business Type:Manufacturers
  • Contact Tel:021-51086038
  • Emails:sales@chemwill.com
  • Main Products:56
  • Country:China (Mainland)
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