71989-14-5

Basic information

• Product Name: FMOC-L-Aspartic acid beta-tert-butyl ester
• Synonyms: Fmoc-(tBu)Asp-OH;cas:71989-14-5;Fmoc-L-aspartic acid β-tert-butyl ester≥ 99.7% (HPLC, Chiral purity);N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-ASPARTIC ACID BETA-T-BUTYL ESTER;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-ASPARTIC ACID BETA-TERT-BUTYL ESTER;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-ASPARTIC ACID BETA-T-BUTYL ESTER;N-9-FLUORENYLMETHYLOXYCARBONYL-L-ASPARTIC ACID BETA-T-BUTYL ESTER;N-9-FLUORENYLMETHYLOXYCARBONYL-L-ASPARTIC ACID BETA-TERT-BUTYL ESTER
• CAS NO: 71989-14-5
• Molecular Formula: C₂₃H₂₅NO₆
• Molecular Weight: 411.45
• EINECS: 276-251-7
• Product Categories: PROTECTED AMINO ACID & PEPTIDES;Amino Acids;Aspartic acid [Asp, D];Fmoc-Amino Acids and Derivatives;Amino Acids (N-Protected);Biochemistry;Fmoc-Amino Acids;Fmoc-Amino acid series
• Mol File: 71989-14-5.mol
• Article Data: 12

Chemical Properties

• Melting Point: 148-150 °C (dec.)
• Boiling Point: 530.45°C (rough estimate)
• Flash Point: 329.3 °C
• Appearance: white to light yellow crystal powder
• Density: 1.2498 (rough estimate)
• Vapor Pressure: 2.83E-16mmHg at 25°C
• Refractive Index: -25 ° (C=1, DMF)
• Storage Temp.: 2-8°C
• PKA: 3.57±0.23(Predicted)
• Water Solubility: Slightly soluble in water.
• BRN: 3635671
• CAS DataBase Reference: FMOC-L-Aspartic acid beta-tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-L-Aspartic acid beta-tert-butyl ester(71989-14-5)
• EPA Substance Registry System: FMOC-L-Aspartic acid beta-tert-butyl ester(71989-14-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25-36/37/39-27-26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 71989-14-5(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powde

Uses

L-Aspartic acid is a nonessential amino acid that is used to biosynthesize other amino acids within the human body.

General Description

The product number for this product was previously 04-12-1013.To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.

InChI:InChI=1/C23H25NO6/c1-23(2,3)30-20(25)12-19(21(26)27)24-22(28)29-13-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,24,28)(H,26,27)/t19-/m0/s1

Upstream product

• 88744-04-1 (9-fluorenyl)methyl pentafluorophenyl carbonate 
• 3057-74-7 L-Asp(t-Bu) 
• 56-84-8 L-Aspartic acid 
• 102774-86-7 9-fluorenylmethyl N-succinimidyl carbonate 
• 115-11-7 isobutene 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 99502-89-3 Chlorameisensaeure-N-hydroxy-norborn-5-en-2,3-dicarboximidester 
• 144120-52-5 4-(1,1-dimethylethyl) ester of Nα-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-aspartic acid allyl ester 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 1334631-58-1 L-aspartic acid β-tert-butyl ester hydrochloride 
• 21715-90-2 N-hydroxy-5-norbornene-2,3-dicarboximide 
• 147221-34-9 Fmoc-Asp(OtBu)OPp 
• 99503-04-5 Carbonic acid 3,5-dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl ester 9H-fluoren-9-ylmethyl ester 

Downstream Products

• 157886-16-3 Fmoc-Asp(Ot-Bu)-ODbn 
• 86061-07-6 Fmoc-Asp(t-Bu)-Phe-NH₂ 
• 99896-85-2 Arg-Gly-Asp 

Relevant articles and documents

COMPOUND FOR PREPARATION OF ANTIBODY-PAYLOAD CONJUGATE AND USE THEREOF

The present application relates to a novel linker for use in bioconjugation, comprising two or more electrophilic carbon atoms of a carbonyl group, and a click chemistry functional group and, more specifically, to a linker through which a compound, a peptide, and/or a protein can be directly and/or indirectly linked by a substitution reaction to a desired target molecule, that is, a target molecule.

Synthesis of l -octaarginine through microencapsulated palladium-catalyzed allyl ester deprotection

Octaarginine has been described as a molecular transporter. We report a useful synthesis of orthogonally protected l-octaarginine by using a method based on a microencapsulated palladium catalyst. Known palladium-based methods for allyl ester deprotection have been modified to facilitate purification of the unprotected intermediates. This improvement in the purification step has also been tested with a variety of allyl α-amino esters and allyl α,β-unsaturated esters.

Efficient procedure for the preparation of oligomer-free N-fmoc amino acids

A two-step method is presented for the peptide-free, high-purity, and high-yield synthesis of N-Fmoc amino acids. The first step involves the preparation of stable dicyclohexylammonium-amino acid ionic adduct in acetone. Subsequently, the ionic adducts, on reaction with Fmoc-Nosu under mild alkaline conditions, give dipeptide-free N-Fmoc amino acids. The positive charge of the dicyclohexylammonium counterion in the ionic salt has a longer radius, moderating the nucleophilicity of the carboxylate ion of the amino acid and preventing by-products by arresting the formation of mixed anhydrides, the precursors of oligopeptide impurities.