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74853-08-0

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74853-08-0 Usage

General Description

1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine, also known as 4-(4-Aminophenyl)-1-(4-hydroxyphenyl)piperazine, is a chemical compound with the molecular formula C17H20N4O. It is a piperazine derivative that contains both an amino group and a hydroxy group. 1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine has potential pharmacological properties, and it has been studied for its potential use in the treatment of various medical conditions, including psychiatric disorders and neurological diseases. Its chemical structure and properties make it a candidate for further research into its potential therapeutic applications. However, its precise biological effects and mechanisms of action have yet to be fully elucidated.

Check Digit Verification of cas no

The CAS Registry Mumber 74853-08-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,8,5 and 3 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 74853-08:
(7*7)+(6*4)+(5*8)+(4*5)+(3*3)+(2*0)+(1*8)=150
150 % 10 = 0
So 74853-08-0 is a valid CAS Registry Number.
InChI:InChI=1/C16H19N3O/c17-13-1-3-14(4-2-13)18-9-11-19(12-10-18)15-5-7-16(20)8-6-15/h1-8,20H,9-12,17H2

74853-08-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine

1.2 Other means of identification

Product number -
Other names 4-[4-(4-aminophenyl)piperazin-1-yl]phenol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:74853-08-0 SDS

74853-08-0Synthetic route

4-[4-(4-benzyloxy-phenyl)-piperazin-1-yl]-phenylamine
184177-84-2

4-[4-(4-benzyloxy-phenyl)-piperazin-1-yl]-phenylamine

1-(4-aminophenyl)-4-(4-hydroxyphenyl)piperazine
74853-08-0

1-(4-aminophenyl)-4-(4-hydroxyphenyl)piperazine

Conditions
ConditionsYield
palladium on activated charcoal In tetrahydrofuran; water at 70℃; under 4137.18 Torr; for 40h;94%
N-(4-Hydroxyphenyl)-N'-(4'-nitrophenyl)-piperazine
112559-81-6

N-(4-Hydroxyphenyl)-N'-(4'-nitrophenyl)-piperazine

1-(4-aminophenyl)-4-(4-hydroxyphenyl)piperazine
74853-08-0

1-(4-aminophenyl)-4-(4-hydroxyphenyl)piperazine

Conditions
ConditionsYield
With sodium hypophosphite; 5%-palladium/activated carbon In 2-methoxy-ethanol; water at 70 - 80℃; for 2 - 2.5h;88%
With ammonium formate; palladium on activated charcoal In ethyl acetate Reduction; Heating;82%
With hydrogen In methanol; ethyl acetate at 35 - 40℃; under 2250.23 Torr; Large scale;
4-[4-(4-methoxy-phenyl)-piperazin-1-yl]-phenylamine
74852-62-3

4-[4-(4-methoxy-phenyl)-piperazin-1-yl]-phenylamine

1-(4-aminophenyl)-4-(4-hydroxyphenyl)piperazine
74853-08-0

1-(4-aminophenyl)-4-(4-hydroxyphenyl)piperazine

Conditions
ConditionsYield
With Cyclohexyl iodide In N,N-dimethyl-formamide at 82 - 85℃; for 3h;85.7%
With hydrogen bromide dealkylation; Heating;
1-(4-benzyloxy-phenyl)-4-(4-nitro-phenyl)-piperazine
454479-35-7

1-(4-benzyloxy-phenyl)-4-(4-nitro-phenyl)-piperazine

1-(4-aminophenyl)-4-(4-hydroxyphenyl)piperazine
74853-08-0

1-(4-aminophenyl)-4-(4-hydroxyphenyl)piperazine

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethanol for 24h; Heating;81%
Multi-step reaction with 2 steps
1: 99 percent / H2 / Pd/C / H2O; tetrahydrofuran / 20 h / 50 °C / 2585.74 Torr
2: 94 percent / Pd/C / H2O; tetrahydrofuran / 40 h / 70 °C / 4137.18 Torr
View Scheme
acetic acid 4-[4-(4-amino-phenyl)-piperazin-1-yl]-phenyl ester

acetic acid 4-[4-(4-amino-phenyl)-piperazin-1-yl]-phenyl ester

1-(4-aminophenyl)-4-(4-hydroxyphenyl)piperazine
74853-08-0

1-(4-aminophenyl)-4-(4-hydroxyphenyl)piperazine

Conditions
ConditionsYield
With water Hydrolysis;

74853-08-0Relevant articles and documents

Preparation method of 4-[4-[4-(4-hydroxyphenyl) piperazine-1-yl] phenyl] phenyl carbamate

-

, (2022/04/08)

The invention discloses a preparation method of 4-[4-[4-(4-hydroxyphenyl) piperazine-1-yl] phenyl] phenyl carbamate, which comprises the following steps: by taking 4-hydroxyaniline as a raw material, carrying out ring closing on the 4-hydroxyaniline and dichloroethylamine hydrochloride to synthesize 1-(4-hydroxyphenyl) piperazine with the purity of 95A% and the correction yield of 80%; 4-nitrochlorobenzene and the prepared 1-(4-hydroxyphenyl) piperazine are coupled to synthesize 4-(4-(4-nitrophenyl)-1-piperazinyl) phenol, the purity is 93 A%, and the correction yield is 88%; then carrying out nitro reduction to synthesize 1-(4-aminophenyl)-4-(4-hydroxyphenyl) piperazine with the purity of 98A% and the correction yield of 77%; and finally, synthesizing 4-[4-[4-(4-hydroxyphenyl) piperazine-1-yl] phenyl] phenyl carbamate with the purity of 98.7%, the content of 98.5 wt% and the correction yield of 83% by using phenyl chloroformate to protect phenolic hydroxyl groups. According to the invention, the high-purity target product 4-[4-[4-(4-hydroxyphenyl) piperazine-1-yl] phenyl] phenyl carbamate can be obtained through easily available raw materials and simple process steps.

Preparation process of posaconazole intermediate 1-(4-hydroxyphenyl)-4-(4-aminophenyl)piperazine

-

Paragraph 0030, (2018/06/23)

The invention relates to the technical field of chemical medicine synthesis, in particular to a preparation process of posaconazole intermediate 1-(4-hydroxyphenyl)-4-(4-aminophenyl)piperazine. The preparation process provided by the invention comprises the following steps of a, preparing methoxyphenyl piperazine hydrochloride; b, preparing p-hydroxyphenyl piperazine hydrobromide; c, preparing 1-(4-hydroxyphenyl)-4-(4-nitrophenyl)piperazine; d, preparing a crude product of 1-(4-hydroxyphenyl)-4-(4-aminophenyl)piperazine; e, purifying a product. Cheap solvents and high-activity nickel catalystsare selected and used; low-pressure hydrogenation reaction is used; the raw material cost is greatly reduced; important links such as nickel ion removal and aluminum ion removal are used for post treatment; the product quality reaches the content of 99.2 percent; the single maximum noise peak value is less than 0.1 percent; the total noise peak value is less than 1.0 percent; the home and abroadmarket competitive power of the product is greatly enhanced.

Mono N-arylation of piperazine(III): Metal-catalyzed N-arylation and its application to the novel preparations of the antifungal posaconazole and its advanced intermediate

Hepperle, Michael,Eckert, Jeffrey,Gala, Dinesh,Shen, Lan,Anderson Evans,Goodman, Andrew

, p. 3359 - 3363 (2007/10/03)

A novel application of Pd0-catalyzed arylation to mono N-arylated piperazines, its mechanism, and its application towards the novel syntheses of the key differentially N,N′-diarylated piperazine antifungal intermediate N-(4-hydroxyphenyl)-N′-(4-aminophenyl)piperazine 5 as well as posaconazole 1 are described.

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