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77-86-1

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77-86-1 Usage

description

Tris, or tris(hydroxymethyl)aminomethane, or known during medical use as tromethamine or THAM, is an organic compound with the formula (HOCH2)3CNH2. It is extensively used in biochemistry and molecular biology as a component of buffer solutions such as in TAE and TBE buffers, especially for solutions of nucleic acids. It contains a primary amine and thus undergoes the reactions associated with typical amines, e.g. condensations with aldehydes. Tris also complexes with metal ions in solution. In medicine, tromethamine is occasionally used as a drug, given in intensive care for its properties as a buffer for the treatment of severe metabolic acidosis in specific circumstances. Some medications are formulated as the "tromethamine salt" including hemabate (carboprost as trometamol salt), and "ketorolac trometamol".

Chemical Properties

Different sources of media describe the Chemical Properties of 77-86-1 differently. You can refer to the following data:
1. White crystal or powder. Melting point 171-172℃, boiling point 219-220℃/1.3kPa, soluble in ethanol and water, slightly soluble in ethyl acetate, benzene, insoluble in ether, carbon tetrachloride,copper,aluminum corrosion effects,irritant.
2. White, crystalline solid. PH (0.1M aqueous solution) 10.6, corrosive to copper, brass, aluminum. Solubility in water 80 g/100 cc (20C). Combustible.

Uses of Biology

Tris base, also known as THAM, is widely used as a biological buffer or as a component of buffer formulations such as TAE and TBE buffers. Tris has a pKa of 8.06 and is very useful in the biology and biochemistry lab because it has buffering capabilities in the range of the typical physiological pH of most living organisms (pH 7.0-9.0). Tris has been reported to interfere with the activity of a number of enzymes, it should therefore be used carefully when studying proteins.

Uses

Different sources of media describe the Uses of 77-86-1 differently. You can refer to the following data:
1. 1, Tris buffer, only nucleic acids and proteins are widely used as solvents. 2, Tris is used for protein crystal growth under different pH conditions. 3, Tris buffer having a low ionic strength can be used nematode (C. elegans) is formed lamin (lamin) intermediate fibers. 4, Tris is a major component of protein electrophoresis buffer. 5, Tris for the preparation of a surfactant, a vulcanization accelerator, and some drug intermediates. 6, Tris titrated also used as standard.
2. tromethamine can help mask odor in a formulation. It is also used as a buffer, keeping product pH stable.
3. In the synthesis of surface-active agents, vulcanization accelerators, pharmaceuticals. As emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, leather dressings, textile specialties, polishes, cleaning Compounds, so-called soluble oils. Absorbent for acidic gases. Biological buffer.
4. Tris base has been used:In the preparation of TAE buffer for TAE agarose gel used to run PCR products by gel electrophoresisAs a component of sample buffer for SDS-PAGEIn the preparation of IEC (ion-exchange chromatography) buffer

Originator

Trisaminol,Bellon,France,1964

Application

Tris(hydroxymethyl)aminomethane is mainly required for preparation of buffers at physiological range of 7.3 to 7.5. The prepared buffers are compatible with biological fluids. It is of importance to laboratories as a standard pH solution.Tris(hydroxymethyl)aminomethane has been used as a buffer solution for lactate dehydrogenase assay, in situ hybridization procedure and protein extraction from cells.Tris(hydroxymethyl)aminomethane is used as a buffer in biochemistry and molecular biology laboratories. It is used as a primary standard to standardize acid solutions for chemical analysis. It finds application in cell membranes to increase permeability. As an alternative to sodium bicarbonate, it used in the treatment of metabolic acidosis. It acts as a precursor for the preparation of polymers, oxazolones and oxazolidines.

Preparation

Tris is prepared industrially by the exhaustive condensation of nitromethane with formaldehyde under basic conditions (i.e. repeated Henry reactions) to produce the intermediate (HOCH2)3CNO2, which is subsequently hydrogenated to give the final product.

Manufacturing Process

Nitromethane is reacted with formaldehyde to give tris(hydroxymethyl)nitromethane in an initial step. This intermediate may be reduced by catalytic hydrogenation (US Patent 2,174,242) or by electrolytic reduction (US Patent 2,485,982).

Brand name

Tham (Hospira).

General Description

Tris is an established basimetric standard and buffer used in biochemistry and molecular biology. It may be used by itself as a buffer or as a component of mixed buffer formulations, such as Tris-EDTA (TE) buffer, Tris-acetate-EDTA (TAE) buffer, Tris-borate-EDTA (TBE) buffer, etc. It is pure, essentially stable, relatively non-hygroscopic and has a high equivalent weight.

Biochem/physiol Actions

Trizma base, commonly known as tris is widely used as a biological buffer or as a component of buffer formulations like- Tris-EDTA (TE) buffer, Tris magnesium buffer or Tris-acetate-EDTA (TAE) buffer. It enhances the membrane permeability of cell membranes.

Purification Methods

TRIS can ordinarily be obtained in highly pure form suitable for use as an acidimetric standard. If only impure material is available, it should be crystallised from 20% EtOH, aqueous MeOH (m 171.1o) or isopropanol (m 172-173o). Dry it in a vacuum desiccator over P2O5 or CaCl2. Alternatively, it is dissolved in twice its weight of water at 55-60o, filtered, concentrated to half its volume and poured slowly, with stirring, into about twice its volume of EtOH. The crystals which separate on cooling to 3-4o are filtered off, washed with a little MeOH, air dried by suction, then finally ground and dried in a vacuum desiccator over P2O5. It has also been recrystallised from water, MeOH or aqueous MeOH, and vacuum dried at 80o for 2 days. [Beilstein 4 H 303, 4 III 857, 4 IV 1903.]

Check Digit Verification of cas no

The CAS Registry Mumber 77-86-1 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 7 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 77-86:
(4*7)+(3*7)+(2*8)+(1*6)=71
71 % 10 = 1
So 77-86-1 is a valid CAS Registry Number.
InChI:InChI:1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2

77-86-1 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (T2516)  Tris(hydroxymethyl)aminomethane [for Electrophoresis]  >99.0%(T)

  • 77-86-1

  • 25g

  • 260.00CNY

  • Detail
  • TCI America

  • (T2516)  Tris(hydroxymethyl)aminomethane [for Electrophoresis]  >99.0%(T)

  • 77-86-1

  • 500g

  • 880.00CNY

  • Detail
  • Alfa Aesar

  • (31801)  Tris(hydroxymethyl)aminomethane, ACS, 99.8-100.1% (Assay, dried basis)   

  • 77-86-1

  • 50g

  • 154.0CNY

  • Detail
  • Alfa Aesar

  • (31801)  Tris(hydroxymethyl)aminomethane, ACS, 99.8-100.1% (Assay, dried basis)   

  • 77-86-1

  • 250g

  • 429.0CNY

  • Detail
  • Alfa Aesar

  • (31801)  Tris(hydroxymethyl)aminomethane, ACS, 99.8-100.1% (Assay, dried basis)   

  • 77-86-1

  • 1kg

  • 1097.0CNY

  • Detail
  • Alfa Aesar

  • (A18494)  Tris(hydroxymethyl)aminomethane, 99%   

  • 77-86-1

  • 100g

  • 248.0CNY

  • Detail
  • Alfa Aesar

  • (A18494)  Tris(hydroxymethyl)aminomethane, 99%   

  • 77-86-1

  • 500g

  • 496.0CNY

  • Detail
  • Alfa Aesar

  • (A18494)  Tris(hydroxymethyl)aminomethane, 99%   

  • 77-86-1

  • 2500g

  • 2086.0CNY

  • Detail
  • Sigma-Aldrich

  • (PHR1347)    pharmaceutical secondary standard; traceable to USP and PhEur

  • 77-86-1

  • PHR1347-1G

  • 732.19CNY

  • Detail
  • Sigma

  • (93350)  Trizma®base  puriss. p.a., ≥99.7% (T)

  • 77-86-1

  • 93350-100G

  • 589.68CNY

  • Detail
  • Sigma

  • (93350)  Trizma®base  puriss. p.a., ≥99.7% (T)

  • 77-86-1

  • 93350-500G

  • 1,613.43CNY

  • Detail
  • Sigma

  • (93350)  Trizma®base  puriss. p.a., ≥99.7% (T)

  • 77-86-1

  • 93350-1KG

  • 2,691.00CNY

  • Detail

77-86-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Trometamol

1.2 Other means of identification

Product number -
Other names 8VTE 1L

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:77-86-1 SDS

77-86-1Synthetic route

{NiCl2(2-(2-pyridinyl)-4,4-bis(hydroxymethyl)-2-oxazoline)2}

{NiCl2(2-(2-pyridinyl)-4,4-bis(hydroxymethyl)-2-oxazoline)2}

A

{Ni(H2O)2(pyridine-2-carboxylic acid)2}*2H2O

{Ni(H2O)2(pyridine-2-carboxylic acid)2}*2H2O

B

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

Conditions
ConditionsYield
In water reflux (50 h);; pptn.; filtration; washing (ethanol); drying (vac.); elem. anal.; evapn. of aq. filtrate; extraction (3 times/hot ethanol); cooling of filtrate yields 2-amino-2-hydroxymethyl-1,3-propanediol;;A 85%
B 75%
2-hydroxymethyl-2-nitro-propane-1,3-diol
126-11-4

2-hydroxymethyl-2-nitro-propane-1,3-diol

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

Conditions
ConditionsYield
With sulfuric acid; iron at 100℃;
With water; iron; iron(II) sulfate at 30℃;
With water; iron; iron(II) sulfate at 100℃;
Protonated tris(hydroxymethyl)aminoamethane
19320-52-6

Protonated tris(hydroxymethyl)aminoamethane

C14H13NO
114444-46-1

C14H13NO

A

1-methyl-4-(phenylacetyl)pyridinium cation
124225-44-1

1-methyl-4-(phenylacetyl)pyridinium cation

B

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

Conditions
ConditionsYield
In water at 25℃; Equilibrium constant; Rate constant;
Protonated tris(hydroxymethyl)aminoamethane
19320-52-6

Protonated tris(hydroxymethyl)aminoamethane

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

Conditions
ConditionsYield
In water; acetonitrile at 25℃; Thermodynamic data; ΔrGm0, var. of solvent, temp.;
N,N'-bis(2,3-dihydroxypropyl)-5-{2-[(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)amino]-2-oxoethoxy}-1,3-benzenedicarboxamide

N,N'-bis(2,3-dihydroxypropyl)-5-{2-[(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)amino]-2-oxoethoxy}-1,3-benzenedicarboxamide

A

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

B

[3,5-Bis-(2,3-dihydroxy-propylcarbamoyl)-phenoxy]-acetic acid

[3,5-Bis-(2,3-dihydroxy-propylcarbamoyl)-phenoxy]-acetic acid

Conditions
ConditionsYield
With water at 95℃; Rate constant;
5-amino-5-hydroxymethyl-2-alkyl-1.3-dioxanene

5-amino-5-hydroxymethyl-2-alkyl-1.3-dioxanene

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

Conditions
ConditionsYield
With mineral acid
Sodium; 2-{[(E)-2-hydroxy-1,1-bis-hydroxymethyl-ethylimino]-methyl}-benzenesulfonate

Sodium; 2-{[(E)-2-hydroxy-1,1-bis-hydroxymethyl-ethylimino]-methyl}-benzenesulfonate

A

sodium 2-formylbenzenesulfonate
1008-72-6

sodium 2-formylbenzenesulfonate

B

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

Conditions
ConditionsYield
In water at 25℃; Equilibrium constant;
C9H18NO10P(2-)*2Na(1+)

C9H18NO10P(2-)*2Na(1+)

A

α,β-D-ribofuranose-5-phophate disodium salt
108321-99-9, 150713-51-2

α,β-D-ribofuranose-5-phophate disodium salt

B

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

Conditions
ConditionsYield
Equilibrium constant;
boc-Pro-Phe-His(Ts)-OH

boc-Pro-Phe-His(Ts)-OH

diethylphosphoryl cyanide

diethylphosphoryl cyanide

A

boc-Pro-Phe-His-LVA-Ile

boc-Pro-Phe-His-LVA-Ile

B

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride; triethylamine; trifluoroacetic acid In tetrahydrofuran; methanol; dichloromethane; ethyl acetate
tris(hydroxymethyl)aminomethane-silicofluoric acid (2/1)

tris(hydroxymethyl)aminomethane-silicofluoric acid (2/1)

A

hydrogen fluoride
7664-39-3

hydrogen fluoride

B

silicon tetrafluoride
7783-61-1

silicon tetrafluoride

C

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

Conditions
ConditionsYield
In neat (no solvent) thermogravimetric expt. (platinum crucible, heating rate of 10 K/min); heating to 200-268°C;
2-propenamide
79-06-1

2-propenamide

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

N,N'-bis[tris(hydroxymethyl)methyl]ethanediamide
5714-31-8

N,N'-bis[tris(hydroxymethyl)methyl]ethanediamide

Conditions
ConditionsYield
at 140℃; for 1h;100%
In ethylene glycol at 100 - 105℃; for 6h; Conversion of starting material;92%
2-(vinyloxy)ethyl isothiocyanate
59565-09-2

2-(vinyloxy)ethyl isothiocyanate

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

1-(2-Hydroxy-1,1-bis-hydroxymethyl-ethyl)-3-(2-vinyloxy-ethyl)-thiourea

1-(2-Hydroxy-1,1-bis-hydroxymethyl-ethyl)-3-(2-vinyloxy-ethyl)-thiourea

Conditions
ConditionsYield
at 70℃; for 1h;100%
ethylene glycol
107-21-1

ethylene glycol

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

C6H12NO5Si

C6H12NO5Si

Conditions
ConditionsYield
With silica gel Heating;100%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

N-(tert-butyloxycarbonyl)-2-amino-2-(hydroxymethyl)propane-1,3-diol
146651-71-0

N-(tert-butyloxycarbonyl)-2-amino-2-(hydroxymethyl)propane-1,3-diol

Conditions
ConditionsYield
In methanol at 20℃;100%
In methanol; water at 20℃; for 72h;100%
With guanidine hydrochloride In ethanol at 35 - 40℃; for 0.0833333h;100%
ethyl trifluoroacetate,
383-63-1

ethyl trifluoroacetate,

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

N-trifluoroacetyl-tris(hydroxymethyl)aminomethane

N-trifluoroacetyl-tris(hydroxymethyl)aminomethane

Conditions
ConditionsYield
In acetonitrile100%
2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

2-azido-2-(hydroxymethyl)propane-1,3-diol

2-azido-2-(hydroxymethyl)propane-1,3-diol

Conditions
ConditionsYield
With triflic azide; sodium hydrogencarbonate; copper(II) sulfate In methanol; toluene at 20℃; for 14h;100%
With sodium azide; zinc(II) chloride; trifluorormethanesulfonic acid; triethylamine In dichloromethane; water
C51H60O6

C51H60O6

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

C53H65NO8

C53H65NO8

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide100%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)pivalamide

N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)pivalamide

Conditions
ConditionsYield
In methanol; water at 20℃; for 72h;100%
dihydrofluorescein
518-44-5

dihydrofluorescein

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

2-hydroxy-1,1-bis-hydroxymethyl-ethyl-ammonium 2-(3,6-dihydroxy-9H-xanthen-9-yl)-benzoate salt

2-hydroxy-1,1-bis-hydroxymethyl-ethyl-ammonium 2-(3,6-dihydroxy-9H-xanthen-9-yl)-benzoate salt

Conditions
ConditionsYield
In ethanol at 20℃; for 2h;100%
Octanal
124-13-0

Octanal

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

C20H39NO3
944882-97-7

C20H39NO3

Conditions
ConditionsYield
In methanol for 3h; Reflux;100%
Carboprost
35700-23-3

Carboprost

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

carboprost tromethamine

carboprost tromethamine

Conditions
ConditionsYield
In methanol at 20℃; for 2h;100%
In isopropyl alcohol at 20℃; for 1h;
(R)-3-(5-chloro-2-oxo-6-(1-(pyridin-2-yl)ethoxy)benzo[d]oxazol-3(2H)-yl)propanoic acid

(R)-3-(5-chloro-2-oxo-6-(1-(pyridin-2-yl)ethoxy)benzo[d]oxazol-3(2H)-yl)propanoic acid

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

2-amino-2-(hydroxymethyl)propane-1,3-diol (R)-3-{5-chloro-2-oxo-6-[1-(pyridin-2-yl)ethoxy]-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

2-amino-2-(hydroxymethyl)propane-1,3-diol (R)-3-{5-chloro-2-oxo-6-[1-(pyridin-2-yl)ethoxy]-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

Conditions
ConditionsYield
In methanol at 20℃; for 0.5h;100%
3-(5-chloro-6-ethyl-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid

3-(5-chloro-6-ethyl-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

2-amino-2-(hydroxymethyl)propane-1,3-diol 3-(5-chloro-6-ethyl-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid

2-amino-2-(hydroxymethyl)propane-1,3-diol 3-(5-chloro-6-ethyl-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid

Conditions
ConditionsYield
In ethanol; water at 20℃; for 1h;100%
3-[5-chloro-6-(2-methylpropyl)-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl]propanoic acid

3-[5-chloro-6-(2-methylpropyl)-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl]propanoic acid

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

2-amino-2-(hydroxymethyl)propane-1,3-diol 3-[5-chloro-6-(2-methylpropyl)-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl]propanoic acid

2-amino-2-(hydroxymethyl)propane-1,3-diol 3-[5-chloro-6-(2-methylpropyl)-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl]propanoic acid

Conditions
ConditionsYield
In methanol; water at 20℃; for 1h;100%
3-(5-chloro-6-ethoxy-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid

3-(5-chloro-6-ethoxy-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

2-amino-2-(hydroxymethyl)propane-1,3-diol 3-(5-chloro-6-ethoxy-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid

2-amino-2-(hydroxymethyl)propane-1,3-diol 3-(5-chloro-6-ethoxy-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid

Conditions
ConditionsYield
In methanol; water at 80℃; for 1h;100%
3-(5-chloro-6-cyclopropoxy-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid

3-(5-chloro-6-cyclopropoxy-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

2-amino-2-(hydroxymethyl)propane-1,3-diol 3-(5-chloro-6-cyclopropoxy-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid

2-amino-2-(hydroxymethyl)propane-1,3-diol 3-(5-chloro-6-cyclopropoxy-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid

Conditions
ConditionsYield
In ethanol; water at 20℃; for 0.5h;100%
3-[5-chloro-6-(2-methoxyethoxy)-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl]propanoic acid

3-[5-chloro-6-(2-methoxyethoxy)-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl]propanoic acid

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

2-amino-2-(hydroxymethyl)propane-1,3-diol 3-[5-chloro-6-(2-methoxyethoxy)-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl]propanoic acid

2-amino-2-(hydroxymethyl)propane-1,3-diol 3-[5-chloro-6-(2-methoxyethoxy)-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl]propanoic acid

Conditions
ConditionsYield
In ethanol; water at 20℃; for 1h;100%
3-[6-(benzyloxy)-5-chloro-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl]propanoic acid

3-[6-(benzyloxy)-5-chloro-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl]propanoic acid

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

2-amino-2-(hydroxymethyl)propane-1,3-diol 3-[6-(benzyloxy)-5-chloro-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl]propanoic acid

2-amino-2-(hydroxymethyl)propane-1,3-diol 3-[6-(benzyloxy)-5-chloro-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl]propanoic acid

Conditions
ConditionsYield
In ethanol; water at 20℃; for 0.5h;100%
3-[5-chloro-2-oxo-6-(pyridin-2-ylmethoxy)-2,3-dihydro-1,3-benzoxazol-3-yl]propanoic acid

3-[5-chloro-2-oxo-6-(pyridin-2-ylmethoxy)-2,3-dihydro-1,3-benzoxazol-3-yl]propanoic acid

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

2-amino-2-(hydroxymethyl)propane-1,3-diol 3-[5-chloro-2-oxo-6-(pyridin-2-ylmethoxy)-2,3-dihydro-1,3-benzoxazol-3-yl]propanoic acid

2-amino-2-(hydroxymethyl)propane-1,3-diol 3-[5-chloro-2-oxo-6-(pyridin-2-ylmethoxy)-2,3-dihydro-1,3-benzoxazol-3-yl]propanoic acid

Conditions
ConditionsYield
In ethanol; water at 20℃; for 1h;100%
3-{5-chloro-6-[(1R)-1-(4-methylpyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

3-{5-chloro-6-[(1R)-1-(4-methylpyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

2-amino-2-(hydroxymethyl)propane-1,3-diol 3-{5-chloro-6-[(1R)-1-(4-methylpyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

2-amino-2-(hydroxymethyl)propane-1,3-diol 3-{5-chloro-6-[(1R)-1-(4-methylpyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

Conditions
ConditionsYield
In methanol at 20℃; for 1h;100%
3-{5-chloro-6-[(1R)-1-(5-methylpyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

3-{5-chloro-6-[(1R)-1-(5-methylpyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

2-amino-2-(hydroxymethyl)propane-1,3-diol 3-{5-chloro-6-[(1R)-1-(5-methylpyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

2-amino-2-(hydroxymethyl)propane-1,3-diol 3-{5-chloro-6-[(1R)-1-(5-methylpyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

Conditions
ConditionsYield
In methanol at 20℃; for 1h;100%
3-{5-chloro-6-[(1R)-1-(5-chloropyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

3-{5-chloro-6-[(1R)-1-(5-chloropyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

2-amino-2-(hydroxymethyl)propane-1,3-diol 3-{5-chloro-6-[(1R)-1-(5-chloropyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

2-amino-2-(hydroxymethyl)propane-1,3-diol 3-{5-chloro-6-[(1R)-1-(5-chloropyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

Conditions
ConditionsYield
In methanol at 20℃; for 1h;100%
3-{5-chloro-6-[(1R)-1-(5-fluoropyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

3-{5-chloro-6-[(1R)-1-(5-fluoropyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

2-amino-2-(hydroxymethyl)propane-1,3-diol 3-{5-chloro-6-[(1R)-1-(5-fluoropyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

2-amino-2-(hydroxymethyl)propane-1,3-diol 3-{5-chloro-6-[(1R)-1-(5-fluoropyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

Conditions
ConditionsYield
In methanol at 20℃; for 2h;100%
3-{5-chloro-6-[(1R)-1-(6-methylpyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

3-{5-chloro-6-[(1R)-1-(6-methylpyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

2-amino-2-(hydroxymethyl)propane-1,3-diol 3-{5-chloro-6-[(1R)-1-(6-methylpyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

2-amino-2-(hydroxymethyl)propane-1,3-diol 3-{5-chloro-6-[(1R)-1-(6-methylpyridin-2-yl)ethoxy]-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl}propanoic acid

Conditions
ConditionsYield
In methanol at 20℃; for 1h;100%
3-{6-chloro-3-oxo-7-[(1R)-1-(pyridin-2-yl)ethoxy]-3,4-dihydro-2H-1,4-benzoxazin-4-yl}propanoic acid

3-{6-chloro-3-oxo-7-[(1R)-1-(pyridin-2-yl)ethoxy]-3,4-dihydro-2H-1,4-benzoxazin-4-yl}propanoic acid

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

2-amino-2-(hydroxymethyl)propane-1,3-diol 3-{6-chloro-3-oxo-7-[(1R)-1-(pyridin-2-yl)ethoxy]-3,4-dihydro-2H-1,4-benzoxazin-4-yl}propanoic acid

2-amino-2-(hydroxymethyl)propane-1,3-diol 3-{6-chloro-3-oxo-7-[(1R)-1-(pyridin-2-yl)ethoxy]-3,4-dihydro-2H-1,4-benzoxazin-4-yl}propanoic acid

Conditions
ConditionsYield
In methanol at 20℃; for 0.5h;100%
3-{6-chloro-5-[(1R)-1-(pyridin-2-yl)ethoxy]-1H-indazol-1-yl}propanoic acid

3-{6-chloro-5-[(1R)-1-(pyridin-2-yl)ethoxy]-1H-indazol-1-yl}propanoic acid

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

2-amino-2-(hydroxymethyl)propane-1,3-diol 3-{6-chloro-5-[(1R)-1-(pyridin-2-yl)ethoxy]-1H-indazol-1-yl}propanoic acid

2-amino-2-(hydroxymethyl)propane-1,3-diol 3-{6-chloro-5-[(1R)-1-(pyridin-2-yl)ethoxy]-1H-indazol-1-yl}propanoic acid

Conditions
ConditionsYield
In methanol at 20℃; for 0.5h;100%
4-{[(6-bromo-3-methyl-2-phenylquinolin-4-yl)carbonyl]amino}-3-fluorobenzoic acid

4-{[(6-bromo-3-methyl-2-phenylquinolin-4-yl)carbonyl]amino}-3-fluorobenzoic acid

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

4-{[(6-bromo-3-methyl-2-phenylquinolin-4-yl)carbonyl]amino}-3-fluorobenzoic acid 2-amino-2-(hydroxymethyl)propane-1,3-diol

4-{[(6-bromo-3-methyl-2-phenylquinolin-4-yl)carbonyl]amino}-3-fluorobenzoic acid 2-amino-2-(hydroxymethyl)propane-1,3-diol

Conditions
ConditionsYield
In 1,4-dioxane; water Heating;100%
4-{[(6-bromo-3-methyl-2-phenylquinolin-4-yl)carbonyl]amino}bicyclo[2.2.2]octane-1-carboxylic acid

4-{[(6-bromo-3-methyl-2-phenylquinolin-4-yl)carbonyl]amino}bicyclo[2.2.2]octane-1-carboxylic acid

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

4-{[(6-bromo-3-methyl-2-phenylquinolin-4-yl)carbonyl]amino}bicyclo[2.2.2]octane-1-carboxylic acid 2-amino-2-(hydroxymethyl)propane-1,3-diol salt

4-{[(6-bromo-3-methyl-2-phenylquinolin-4-yl)carbonyl]amino}bicyclo[2.2.2]octane-1-carboxylic acid 2-amino-2-(hydroxymethyl)propane-1,3-diol salt

Conditions
ConditionsYield
In ethanol; water Heating;100%
carboprost

carboprost

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

tromethamine prostaglandin

tromethamine prostaglandin

Conditions
ConditionsYield
In dichloromethane at 20℃; for 12h;100%
2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]benzoic acid
501919-59-1

2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]benzoic acid

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]benzoic acid 2-amino-2-(hydroxymethyl)-1,3-propanediol

2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]benzoic acid 2-amino-2-(hydroxymethyl)-1,3-propanediol

Conditions
ConditionsYield
In tetrahydrofuran; ethanol at 0℃; for 1.5h; Solvent;100%

77-86-1Relevant articles and documents

Segl'a, P.,Jamnicky, M.

, p. 221 - 230 (1993)

Sanger dideoxy sequencing of DNA

Walker, Sarah E.,Lorsch, Jon

, p. 171 - 184 (2013)

While the ease and reduced cost of automated DNA sequencing has largely obviated the need for manual dideoxy sequencing for routine purposes, specific applications require manual DNA sequencing. For instance, in studies of enzymes or proteins that bind or modify DNA, a DNA ladder is often used to map the site at which an enzyme is bound or a modification occurs. In these cases, the Sanger method for dideoxy sequencing provides a rapid and facile method for producing a labeled DNA ladder.

Solution Dynamics of Hybrid Anderson-Evans Polyoxometalates

Salazar Marcano, David E.,Lentink, Sarah,Moussawi, Mhamad A.,Parac-Vogt, Tatjana N.

supporting information, p. 10215 - 10226 (2021/05/31)

Understanding the stability and speciation of metal-oxo clusters in solution is essential for many of their applications in different areas. In particular, hybrid organic-inorganic polyoxometalates (HPOMs) have been attracting increasing attention as they combine the complementary properties of organic ligands and metal-oxygen nanoclusters. Nevertheless, the speciation and solution behavior of HPOMs have been scarcely investigated. Hence, in this work, a series of HPOMs based on the archetypical Anderson-Evans structure, δ-[MnMo6O18{(OCH2)3C-R}2]3-, with different functional groups (R = -NH2, -CH3, -NHCOCH2Cl, -NCH(2-C5H4N) {pyridine; -Pyr}, and -NHCOC9H15N2OS {biotin; -Biot}) and countercations (tetrabutylammonium {TBA}, Li, Na, and K) were synthesized, and their solution behavior was studied in detail. In aqueous solutions, decomposition of HPOMs into the free organic ligand, [MoO4]2-, and free Mn3+ was observed over time and was shown to be highly dependent on the pH, temperature, and nature of the ligand functional group but largely independent of ionic strength or the nature of the countercation. Furthermore, hydrolysis of the amide and imine bonds often present in postfunctionalized HPOMs was also observed. Hence, HPOMs were shown to exhibit highly dynamic behavior in solution, which needs to be carefully considered when designing HPOMs, particularly for biological applications.

Topical acne vulgaris composition with a sunscreen

-

, (2009/03/07)

Increased compliance in the use of topical sunscreens is obtained by combining a topical sunscreen agent in a formulation containing an antibacterial medication such as azelaic acid or an antibiotic.

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