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Cas Database

77047-87-1

77047-87-1

Identification

  • Product Name:Zinc,bromo(1-methylethyl)- (9CI)

  • CAS Number: 77047-87-1

  • EINECS:

  • Molecular Weight:188.383

  • Molecular Formula: C3H7 Br Zn

  • HS Code:29319090

  • Mol File:77047-87-1.mol

Synonyms:Zinc,bromoisopropyl- (7CI)

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Safety information and MSDS view more

  • Pictogram(s):

  • Hazard Codes:F+,Xi,Xn,F

  • Signal Word:Danger

  • Hazard Statement:H261 In contact with water releases flammable gasH302 Harmful if swallowed H312 Harmful in contact with skin H314 Causes severe skin burns and eye damage H332 Harmful if inhaled

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:2-Propylzinc bromide solution 0.5 M in THF
  • Packaging:50ml
  • Price:$ 254
  • Delivery:In stock
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  • Manufacture/Brand:Rieke Metals
  • Product Description:2-Propylzincbromide
  • Packaging:50mL
  • Price:$ 336
  • Delivery:In stock
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  • Manufacture/Brand:Rieke Metals
  • Product Description:2-Propylzincbromide
  • Packaging:50mL
  • Price:$ 263
  • Delivery:In stock
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  • Manufacture/Brand:Rieke Metals
  • Product Description:2-Propylzincbromide
  • Packaging:100mL
  • Price:$ 596
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:2-Propylzincbromide 0.50MinTHF97%
  • Packaging:100ml
  • Price:$ 698
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:2-Propylzincbromide 0.50MinTHF97%
  • Packaging:50ml
  • Price:$ 435
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:2-PROPYLZINC BROMIDE 95.00%
  • Packaging:1L
  • Price:$ 7969.5
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:2-PROPYLZINC BROMIDE 95.00%
  • Packaging:500ML
  • Price:$ 5313
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:2-PROPYLZINC BROMIDE 95.00%
  • Packaging:100ML
  • Price:$ 2795.1
  • Delivery:In stock
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  • Manufacture/Brand:Alfa Aesar
  • Product Description:Isopropylzinc bromide, 0.5M in THF, packaged under Argon in resealable ChemSeal? bottles
  • Packaging:50ml
  • Price:$ 197
  • Delivery:In stock
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Relevant articles and documentsAll total 6 Articles be found

Efficient analoging around ethionamide to explore thioamides bioactivation pathways triggered by boosters in Mycobacterium tuberculosis

Prieri, Marion,Frita, Rosangela,Probst, Nicolas,Sournia-Saquet, Alix,Bourotte, Marilyne,Déprez, Benoit,Baulard, Alain R.,Willand, Nicolas

, p. 35 - 46 (2018/10/02)

Ethionamide is a key antibiotic prodrug of the second-line chemotherapy regimen to treat tuberculosis. It targets the biosynthesis of mycolic acids thanks to a mycobacterial bioactivation carried out by the Baeyer-Villiger monooxygenase EthA, under the control of a transcriptional repressor called EthR. Recently, the drug-like molecule SMARt-420, which triggers a new transcriptional regulator called EthR2, allowed the derepression a cryptic alternative bioactivation pathway of ethionamide. In order to study the bioactivation of a collection of thioisonicotinamides through the two bioactivation pathways, we developed a new two-step chemical pathway that led to the efficient synthesis of eighteen ethionamide analogues. Measurements of the antimycobacterial activity of these derivatives, used alone and in combination with boosters BDM41906 or SMARt-420, suggest that the two different bioactivation pathways proceed via the same mechanism, which implies the formation of similar metabolites. In addition, an electrochemical study of the aliphatic thioisonicotinamide analogues was undertaken to see whether their oxidation potential correlates with their antitubercular activity measured in the presence or in the absence of the two boosters.

Palladium-Catalyzed Cross-Coupling of Silyl Electrophiles with Alkylzinc Halides: A Silyl-Negishi Reaction

Cinderella, Andrew P.,Vulovic, Bojan,Watson, Donald A.

supporting information, p. 7741 - 7744 (2017/06/21)

We report the first example of a silyl-Negishi reaction between secondary zinc organometallics and silicon electrophiles. This palladium-catalyzed process provides direct access to alkyl silanes. The delicate balance of steric and electronic parameters of the employed DrewPhos ligand is paramount to suppressing isomerization and promoting efficient and selective cross-coupling.

Highly regioselective three-component domino heck-negishi coupling reaction for the functionalization of purines at C6

Wang, Dong-Chao,Niu, Hong-Ying,Xie, Ming-Sheng,Qu, Gui-Rong,Wang, Hui-Xuan,Guo, Hai-Ming

supporting information, p. 262 - 265 (2014/01/23)

A highly regioselective three-component domino Heck-Negishi coupling reaction has been developed. Organozinc reagents are used to trap an alkylpalladium intermediate of olefins for a first example in the domino Heck reaction. This reaction is applicable t

Pd-PEPPSI-IPentCl: A highly effective catalyst for the selective cross-coupling of secondary organozinc reagents

Pompeo, Matthew,Hadei, Niloufar,Organ, Michael G.,Froese, Robert D. J.

, p. 11354 - 11357,4 (2012/12/12)

No migration? No problem. A series of new N-heterocyclic carbene based Pd complexes has been created and evaluated in the Negishi cross-coupling of aryl and heteroaryl chlorides, bromides, and triflates with a variety of secondary alkylzinc reagents (see scheme). The direct elimination product is nearly exclusively formed; in most examples there is no migratory insertion at all. Copyright

Pd-PEPPSI-IPentCl: A highly effective catalyst for the selective cross-coupling of secondary organozinc reagents

Pompeo, Matthew,Froese, Robert D. J.,Hadei, Niloufar,Organ, Michael G.

, p. 11354 - 11357 (2013/01/15)

No migration? No problem! A series of new N-heterocyclic carbene based Pd complexes has been created and evaluated in the Negishi cross-coupling of aryl and heteroaryl chlorides, bromides, and triflates with a variety of secondary alkylzinc reagents (see scheme). The direct elimination product is nearly exclusively formed; in most examples there is no migratory insertion at all. Copyright

Process route upstream and downstream products

Process route

isopropyl bromide
75-26-3

isopropyl bromide

isopropyl zinc bromide
77047-87-1

isopropyl zinc bromide

Conditions
Conditions Yield
zinc; With copper(l) iodide; sodium t-butanolate; In methyl cyclohexane; at 70 ℃; for 2h; Heating / reflux;
isopropyl bromide; In methyl cyclohexane; at 60 - 70 ℃; for 3h;
84.1%
zinc; With lithium chloride; for 0.5h; Inert atmosphere;
With ethylene dibromide; In tetrahydrofuran; at 60 ℃; for 0.333333h; Inert atmosphere;
isopropyl bromide; Further stages;
With chloro-trimethyl-silane; In 1,4-dioxane; at 100 ℃; for 20h; Inert atmosphere; Schlenk technique;
With iodine; lithium chloride; In tetrahydrofuran; at 50 ℃; for 18h; Inert atmosphere;
isopropyl bromide
75-26-3

isopropyl bromide

isopropyl zinc bromide
77047-87-1

isopropyl zinc bromide

Conditions
Conditions Yield
With chloro-trimethyl-silane; ethylene dibromide; lithium chloride; zinc; In tetrahydrofuran; at 20 - 50 ℃; Inert atmosphere; Schlenk technique;
isopropyl bromide
75-26-3

isopropyl bromide

isopropyl zinc bromide
77047-87-1

isopropyl zinc bromide

Conditions
Conditions Yield
zinc; With copper(l) iodide; sodium t-butanolate; In methyl cyclohexane; at 70 ℃; for 2h; Heating / reflux;
isopropyl bromide; In methyl cyclohexane; at 60 - 70 ℃; for 3h;
84.1%
zinc; With lithium chloride; for 0.5h; Inert atmosphere;
With ethylene dibromide; In tetrahydrofuran; at 60 ℃; for 0.333333h; Inert atmosphere;
isopropyl bromide; Further stages;
With chloro-trimethyl-silane; In 1,4-dioxane; at 100 ℃; for 20h; Inert atmosphere; Schlenk technique;
With iodine; lithium chloride; In tetrahydrofuran; at 50 ℃; for 18h; Inert atmosphere;
isopropyl bromide
75-26-3

isopropyl bromide

isopropyl zinc bromide
77047-87-1

isopropyl zinc bromide

Conditions
Conditions Yield
With chloro-trimethyl-silane; ethylene dibromide; lithium chloride; zinc; In tetrahydrofuran; at 20 - 50 ℃; Inert atmosphere; Schlenk technique;

Global suppliers and manufacturers

Global( 17) Suppliers
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  • Antimex Chemical Limied
  • Business Type:Lab/Research institutions
  • Contact Tel:0086-21-50563169
  • Emails:anthony@antimex.com
  • Main Products:163
  • Country:China (Mainland)
  • Skyrun Industrial Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:0086-576-84610586
  • Emails:sales@chinaskyrun.com
  • Main Products:18
  • Country:China (Mainland)
  • Sigma-Aldrich Chemie GmbH
  • Business Type:Trading Company
  • Contact Tel:800 558-9160
  • Emails:romesh.collins@milliporesigma.com
  • Main Products:1
  • Country:Germany
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