81190-81-0

Basic information

• Product Name: 3,5-dimethyl-4-trans-styrylisoxazole
• Synonyms: 3,5-dimethyl-4-trans-styrylisoxazole
• CAS NO: 81190-81-0
• Molecular Weight: 199.252
• Mol File: 81190-81-0.mol

Chemical Properties

• CAS DataBase Reference: 3,5-dimethyl-4-trans-styrylisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-dimethyl-4-trans-styrylisoxazole(81190-81-0)
• EPA Substance Registry System: 3,5-dimethyl-4-trans-styrylisoxazole(81190-81-0)

Safety Data

• Hazardous Substances Data: 81190-81-0(Hazardous Substances Data)

Upstream product

• 10557-85-4 4-iodo-3,5-dimethylisoxazole 
• 4363-35-3 Dihydroxy-styryl-boran 
• 300-87-8 3,5-dimethyl-1,2-oxazole 
• 100-42-5 styrene 
• 13329-40-3 4-Iodoacetophenone 
• 1147765-35-2 1,3-bis((E)-4-methoxystyryl)-1,1,3,3-tetramethyldisiloxane 
• 72761-85-4 trans,trans-1,7-diphenyl-3,3,5,5-tetramethyl-3,5-disila-4-oxahepta-1,6-diene 

Relevant articles and documents

Highly Site Selective Formal [5+2] and [4+2] Annulations of Isoxazoles with Heterosubstituted Alkynes by Platinum Catalysis: Rapid Access to Functionalized 1,3-Oxazepines and 2,5-Dihydropyridines

Platinum-catalyzed formal [5+2] and [4+2] annulations of isoxazoles with heterosubstituted alkynes enabled the atom-economical synthesis of valuable 1,3-oxazepines and 2,5-dihydropyridines, respectively. Importantly, this Pt catalysis not only led to unique reactivity dramatically divergent from that observed under Au catalysis, but also proceeded via unprecedented α-imino platinum carbene intermediates.

Studies on the palladium-catalysed direct alkenylation of 1,2-azoles

Electron-rich isoxazoles, isothiazoles and pyrazoles undergo palladium-catalysed direct alkenylation in moderate yields.

Fluoride-free cross coupling using vinyldisiloxanes

Vinyldisiloxanes equilibrate with the corresponding silanolates under basic conditions and subsequently undergo palladium catalysed cross coupling with aryl/heteroaryl iodides and bromides. The Royal Society of Chemistry 2009.

CROSS-COUPLING REACTIONS OF HALOISOXAZOLES WITH OLEFINS AND ACETYLENES

3,5-Dimethyl-4-iodoisoxazole (1a) reacted with phenylacetylene with catalysis by palladium (II) chloride-triphenylphosphine complex to give 3,5-dimethyl-4-phenylethynylisoxazole (2a).When 1a was treated with styrene under similar conditions, 3,5-dimethyl-