82294-70-0

Basic information

• Product Name: 4-Methylthiazole-5-carboxaldehyde
• Synonyms: FMT;IFLAB-BB F2124-0219;4-METHYL-5-THIAZOLECARBOXALDEHYDE;4-METHYL-5-FORMYLTHIAZOLE;4-METHYL-5-THIAZOLYL ALDEHYDE;4-METHYLTHIAZOLE-5-ALDEHYDE;4-METHYL-THIAZOLE-5-CARBALDEHYDE;4-METHYLTHIAZOLE-5-CARBOXALDEHYDE
• CAS NO: 82294-70-0
• Molecular Formula: C₅H₅NOS
• Molecular Weight: 127.16
• EINECS: 1308068-626-2
• Product Categories: ALDEHYDE;Aldehydes;Thiazoles, Isothiazoles &Benzothiazoles;heterocyclic/Aliphatic series;Thiazoles, Isothiazoles & Benzothiazoles;Building Blocks;Heterocyclic Building Blocks;Thiazoles
• Mol File: 82294-70-0.mol
• Article Data: 17

Chemical Properties

• Melting Point: 74-78 °C(lit.)
• Boiling Point: 118°C/21mmHg(lit.)
• Flash Point: 91.8 °C
• Appearance: /
• Density: 1.27 g/cm³
• Vapor Pressure: 0.0747mmHg at 25°C
• Refractive Index: 1.601
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 1.53±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 4-Methylthiazole-5-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methylthiazole-5-carboxaldehyde(82294-70-0)
• EPA Substance Registry System: 4-Methylthiazole-5-carboxaldehyde(82294-70-0)

Safety Data

• Hazard Codes: Xi
• Statements: 41-43
• Safety Statements: 26-39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 82294-70-0(Hazardous Substances Data)

Usage

Uses

4-Methylthiazole-5-carboxaldehyde is used as pharmaceutical intermediate.

InChI:InChI=1/C5H5NOS/c1-4-5(2-7)8-3-6-4/h2-3H,1H3

Upstream product

• 408526-37-4 4-methylthiazole-5-carbonitrile 
• 20582-55-2 ethyl 4-methylthiazole-5-carboxylate 
• 1977-06-6 (4-methyl-1,3-thiazol-5-yl)methanol 
• 5255-33-4 (4-methylthiazol-5-yl)acetic acid 
• 54237-09-1 4-methylthiazole-5-carboxylic acid chloride 
• 13750-63-5 (4-methylthiazol-2-yl)-methanol 
• 79-37-8 oxalyl dichloride 
• 860182-30-5 4-methyl-thiazole-5-carboxylic acid dipropylamide 
• 89179-72-6 4-methyl-thiazole-5-carboxylic acid hydrazide 
• 81569-44-0 methyl 4-methyl thiazole-5-carboxylate 
• 181424-10-2 5-bromomethyl-4-methyl-thiazole 
• 3581-91-7 4,5-Dimethylthiazole 
• 137-00-8 5-hydroxyethyl-4-methylthiazole 
• 103987-43-5 N-benzenesulfonyl-N'-(4-methyl-thiazole-5-carbonyl)-hydrazine 

Downstream Products

• 112953-21-6 Diphenylmethyl (6R,7R)-3-<(Z)-2-(4-Methyl-1,3-thiazol-5-yl)vinyl>-7-phenylacetamidoceph-3-em-4-carboxylate 
• 135299-73-9 Diphenylmethyl (6R,7R)-3-<(E)-2-(4-Methyl-1,3-thiazol-5-yl)vinyl>-7-phenylacetamidoceph-3-em-4-carboxylate 
• 138514-31-5 7-phenylacetamido-3-[(Z)-2-(4-methyl-5-thiazolyl)ethenyl]-4-aminocephalosporanic acid p-methoxybenzylester 
• 104146-11-4 p-Methoxybenzyl 7-phenylacetamido-3(E)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylate 
• 247216-73-5 (E)-5-(N-benzylformimidoyl)-4-methylthiazole 
• 1288341-61-6 4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-N-[(4-methylthiazol-5-yl)methyl]aniline 
• 55327-23-6 4-methyl-2-phenylthiazole-5-carbaldehyde 
• 1588946-25-1 2-[(4-methoxyphenyl)amino]-2-(4-methylthiazol-5-yl)acetonitrile 
• 111600-93-2 5-ethynyl-4-methylthiazole 

Relevant articles and documents

Synthesis method of 4-methylthiazole-5-formaldehyde

The invention provides a synthesis method of 4-methylthiazole-5-formaldehyde. The method comprises the following steps: 1) dissolving 4-methylthiazole-5-ethanol in a solvent, and carrying out oxidation reaction in the presence of a catalyst to obtain 4-methylthiazole-5-acetic acid; and 2) carrying out heating reaction on the 4-methylthiazole-5-acetic acid obtained in the step 1) in the presence of oxygen and a metal salt catalyst to obtain the 4-methylthiazole-5-formaldehyde. According to the method, 4-methylthiazole-5-ethanol is used as a raw material, the raw material is green, cheap and easy to obtain, the reaction process is mild in condition and environmentally friendly, the result selectivity is good, the yield is high, good economic benefits are achieved, and the method is suitable for industrial production.

Novel preparation method for 4-methylthiazole-5-carboxaldehyde

The invention discloses a novel preparation method of 4-methylthiazole-5-carboxaldehyde. The novel preparation method includes the steps of subjecting 2-amino-4-methylthiazole to amino methylation toobtain 2-methylamino-4-methylthiazole, subjecting the 2-methylamino-4-methylthiazole to Vilsmeier reaction to obtain 2-methylamino-4-methyl-5-thiazolecarboxaldehyde, and hydrogenating the 2-methylamino-4-methyl-5-thiazolecarboxaldehyde to remove methylamino to obtain the 4-methylthiazole-5-carboxaldehyde. The preparation method has the advantages of moderate reaction condition, high yield, less generated waste and suitability for mass industrial production.

HETEROARYL COMPOUNDS AS PDE10A INHIBITORS

The present invention provides heteroaryl compounds as Phosphodiesterase 10A (PDE I OA) inhibitors. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders by inhibiting Phosphodiesterase 10A enzyme. Also provided herein are processes for preparing compounds described herein, Formula (I), intermediates used in their synthesis, pharmaceutical compositions thereof.