84110-40-7 Usage
Uses
Used in Suzuki Reaction:
Isobutaneboronic acid is used as a reactant in the Suzuki reaction, a type of cross-coupling reaction that forms carbon-carbon bonds. This reaction is widely used in the synthesis of various organic compounds, including pharmaceuticals and agrochemicals.
Used in Pharmaceutical Industry:
Isobutaneboronic acid is used as a reactant in the preparation of isocoumarin analogs as inhibitors of γ-secretase cleavage. These analogs have potential applications in the treatment of neurodegenerative diseases such as Alzheimer's disease.
Used in Peptide Synthesis:
Isobutaneboronic acid is used as a reactant in the preparation of peptide boronic acids, which are important building blocks in the synthesis of various bioactive peptides and peptidomimetics.
Used in Polymerization Industry:
Isobutaneboronic acid can be used as a catalyst along with aluminum hydroxide and boric acid in the polymerization of styrene. This application contributes to the development of new polymer materials with improved properties.
Used in Organic Synthesis:
Isobutaneboronic acid is used as a reactant in copper-catalyzed cross-coupling reactions, which are important for the formation of carbon-carbon bonds in the synthesis of complex organic molecules.
Used in the Synthesis of Polyborylalkanes:
Isobutaneboronic acid is used as a reactant in the synthesis of polyborylalkanes by Ir-catalyzed C-H borylation reaction. This reaction provides a new method for the synthesis of polyborylalkanes, which have potential applications in various fields, including materials science and pharmaceuticals.
Used in the Preparation of Heterosubstituted Diazaboroles and Borinines:
Isobutaneboronic acid is used as a reactant in the preparation of heterosubstituted diazaboroles and borinines. These compounds have potential applications as catalysts, ligands, and pharmaceutical agents.
Reference
J. Adams, M. Behnke, S. Chen, A. A. Cruickshank, L. R. Dick, L. Grenier, J. M. Klunder, Y. Ma, L. Plamondon, R. L. Stein, Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids, Bioorganic & Medicinal Chemistry Letters, 1998, vol. 8, pp. 333-338
Check Digit Verification of cas no
The CAS Registry Mumber 84110-40-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,1,1 and 0 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 84110-40:
(7*8)+(6*4)+(5*1)+(4*1)+(3*0)+(2*4)+(1*0)=97
97 % 10 = 7
So 84110-40-7 is a valid CAS Registry Number.
InChI:InChI=1/C4H11BO2/c1-4(2)3-5(6)7/h4,6-7H,3H2,1-2H3
84110-40-7Relevant articles and documents
Efficient hydrolysis of organotrifluoroborates via silica gel and water
Molander, Gary A.,Cavalcanti, Livia N.,Canturk, Belgin,Pan, Po-Shen,Kennedy, Lauren E.
supporting information; experimental part, p. 7364 - 7369 (2010/01/16)
(Chemical Equation Presented) A general, mild, and efficient method for the hydrolysis of organotrifluoroborates to unveil boronic acids using silica gel and H2O was developed. This method proved to be tolerant of a broad range of aryl-, heteroaryl-, alkenyl-, and alkyltrifluoroborates as well as structurally diverse aminomethylated organotrifluoroborates.As anticipated, electron-rich substrates provided the corresponding boronic acids more readily than electron-poor substrates, owing to the resonance-stabilized difluoroborane intermediate. The method developed was expanded further for the conversion of organotrifluoroborates to the corresponding boronate esters. 2009 American Chemical Society.
P1 Phenethyl peptide boronic acid inhibitors of HCV NS3 protease
Priestley,De Lucca, Indawati,Ghavimi, Bahman,Erickson-Viitanen, Susan,Decicco, Carl P.
, p. 3199 - 3202 (2007/10/03)
A series of peptide boronic acids containing extended, hydrophobic P1 residues was prepared to probe the shallow, hydrophobic S1 region of HCV NS3 protease. The p-trifluoromethylphenethyl P1 substituent was identified as optimal with respect to inhibitor potency for NS3 and selectivity against elastase and chymotrypsin.
