858854-82-7

Basic information

• Product Name: 3-CHLORO-2-IODOPHENOL
• Synonyms: 3-CHLORO-2-IODOPHENOL;3-Choro-2-iodophenol
• CAS NO: 858854-82-7
• Molecular Formula: C₆H₄ClIO
• Molecular Weight: 254.45
• Product Categories: pharmacetical
• Mol File: 858854-82-7.mol

Chemical Properties

• Melting Point: 56 °C
• Boiling Point: 225.6°C at 760 mmHg
• Flash Point: 90.2°C
• Appearance: /
• Density: 2.087g/cm³
• Vapor Pressure: 0.0572mmHg at 25°C
• Refractive Index: 1.677
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 7.55±0.10(Predicted)
• CAS DataBase Reference: 3-CHLORO-2-IODOPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-2-IODOPHENOL(858854-82-7)
• EPA Substance Registry System: 3-CHLORO-2-IODOPHENOL(858854-82-7)

Safety Data

• Hazardous Substances Data: 858854-82-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-2-iodophenol is utilized as an intermediate in the synthesis of pharmaceuticals, contributing to the development of new drugs. Its unique chemical structure allows for the creation of a variety of medicinal compounds, enhancing the range of treatments available.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Chloro-2-iodophenol serves as an intermediate in the production of agrochemicals, potentially leading to the development of novel pesticides or other agricultural products that can improve crop protection and yield.
Used in Medicinal Chemistry:
3-Chloro-2-iodophenol has potential applications in medicinal chemistry due to its distinctive chemical properties, which can be leveraged to synthesize new compounds with therapeutic potential.
Used in Material Science:
Its reactivity and unique structure also make 3-Chloro-2-iodophenol a candidate for material science applications, where it could be used in the development of new materials with specific properties.
It is crucial to handle 3-Chloro-2-iodophenol with care, adhering to safety guidelines to mitigate its potential toxicity and harmful effects on human health and the environment.

InChI:InChI=1/C6H4ClIO/c7-4-2-1-3-5(9)6(4)8/h1-3,9H

Upstream product

• 2845-89-8 1-chloro-3-methoxy-benzene 
• 91105-99-6 1-chloro-3-(methoxymethoxy)benzene 
• 791642-67-6 1-chloro-2-iodo-3-methoxybenzene 
• 108-43-0 3-monochlorophenol 
• 159390-33-7 3-chlorophenyl N,N-diethylcarbamate 
• 863870-77-3 3-chloro-2-iodophenyl N,N-dimethyl O-carbamate 
• 56962-00-6 2-amino-3-chlorophenol 

Downstream Products

• 1287791-66-5 2-(3-chloro-2-iodophenoxy)-2-methylpropanamide 
• 25235-85-2 4-chloro-1H-indole 
• 70237-25-1 3-chloro-2-iodobenzenamine 
• 108-42-9 3-chloro-aniline 
• 1244651-45-3 N-(3-chloro-2-(hex-1-ynyl)phenyl)-2-hydroxy-2-methylpropanamide 
• 1244651-49-7 N-(3-chloro-2-(hept-1-ynyl)phenyl)-2-hydroxy-2-methylpropanamide 
• 1244651-54-4 N-(3-chloro-2-(2-(trimethylsilyl)ethynyl)phenyl)-2-hydroxy-2-methylpropanamide 
• 1244652-07-0 4-chloro-2-(3-chlorophenyl)-1H-indole 
• 1244651-34-0 N-(3-chloro-2-iodophenyl)-2-hydroxy-2-methylpropanamide 
• 1287792-07-7 2-butyl-4-chloro-3-(phenylthio)-1H-indole 

Relevant articles and documents

KINASE INHIBITOR

[Problem] To provide a novel PIM-3 inhibitor and a novel cancer therapeutic drug, in particular, a therapeutic drug for pancreatic cancer. [Solution] A PIM-3 kinase inhibitor comprising a compound represented by general formula (I) or a pharmacologically acceptable salt, hydrate or solvate thereof.

Atropo-diastereoselective coupling of aryllithiums and arynes — variations around the chiral auxiliary

The atropo-selective coupling of in situ generated arynes and aryllithiums bearing various chiral auxiliaries ortho to lithium (tert-butylsulfoxide, para-tolylsulfoxide, tartrate-derived chiral diethers and oxazolines) is described. Chiral oxazolines showed the best results in terms of yields of coupling products. Different reaction parameters like the nature of the aryne precursor, the oxazoline, the alkyllithium base or the solvent revealed to be crucial for obtaining good yields and for diastereoselection.

Approaches to the synthesis of 2,3-dihaloanilines. Useful precursors of 4-functionalized-1 H-indoles

2,3-Dihaloanilines have been proved as useful starting materials for synthesizing 4-halo-1H-indoles. Subsequent or in situ functionalization of the prepared haloindoles allows the access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles in good overall yields. As no efficient synthetic routes to 2,3-dihaloanilines have been described in the literature, different approaches to the preparation of these 1,2,3-functionalized aromatic precursors are now presented. The most general one involves a Smiles rearrangement from the corresponding 2,3-dihalophenols and allows the preparation of 2,3-dihaloanilides in a straightforward and synthetically useful manner.

Synthesis of 4-functionalized-1H-indoles from 2,3-dihalophenols

A new synthesis of 4-halo-1H-indoles has been developed from easily available 2,3-dihalophenol derivatives. The key steps are Smiles rearrangement and a one-pot or stepwise Sonogashira coupling/NaOH-mediated cyclization. Subsequent functionalization allows access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles.

Compounds and Methods for Inhibiting the Interaction of BCL Proteins with Binding Partners

The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.

Regioselective synthesis of 4- and 7-alkoxyindoles from 2,3-dihalophenols: Application to the preparation of indole inhibitors of phospholipase A 2

(Chemical Equation Presented) An efficient and regioselective synthesis of 4- and 7-alkoxyindoles has been developed from commercially available starting materials such as 3-halophenols and 3-chloroanisole. Directed ortho-metalation followed by two pallad

A new and efficient synthesis of 4-functionalized benzo[6]furans from 2,3-dihalophenols

Tandem Sonogashira coupling/5-endo-dig cyclization reactions on 2,3-dihalophenols suppose a straightforward entry to 4-halobenzo[b]furans, which can be easily transformed into 4-functionalized benzo[b]furans, that are difficult to synthesize by other proc