959-23-9

Basic information

• Product Name: 4'-METHOXYCHALCONE
• Synonyms: 4'-METHOXYCHALCONE;2-BENZYLIDENE-4'-METHOXYACETOPHENONE;1-(4-METHOXYPHENYL)-3-PHENYLPROP-2-EN-1-ONE;METHOXYCHALCONE, 4'-;(E)-1-(4-METHOXYPHENYL)-3-PHENYLPROP-2-EN-1-ONE;RARECHEM AM UC 0609;alpha-styryl p-anisyl ketone;4'-METHOXYCHALCONE 97%
• CAS NO: 959-23-9
• Molecular Formula: C₁₆H₁₄O₂
• Molecular Weight: 238.28
• EINECS: 213-495-5
• Product Categories: Chalcones;C15 to C38;Carbonyl Compounds;Ketones
• Mol File: 959-23-9.mol
• Article Data: 148

Chemical Properties

• Melting Point: 101-103 °C(lit.)
• Boiling Point: 397.5°Cat760mmHg
• Flash Point: 180.5°C
• Appearance: /
• Density: 1.114g/cm³
• Water Solubility: Soluble in dichloromethane and methanol. Insoluble in water.
• BRN: 644640
• CAS DataBase Reference: 4'-METHOXYCHALCONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-METHOXYCHALCONE(959-23-9)
• EPA Substance Registry System: 4'-METHOXYCHALCONE(959-23-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 959-23-9(Hazardous Substances Data)

Usage

Description

4'-METHOXYCHALCONE is an organic compound that serves as a key intermediate in the synthesis of various pharmaceuticals and chemical compounds. It is characterized by its unique structure, which includes a chalcone backbone with a methoxy group attached to the 4' position of the phenyl ring. This structural feature endows 4'-METHOXYCHALCONE with specific chemical properties and reactivity, making it a valuable building block in organic synthesis.

Uses

Used in Pharmaceutical Industry:
4'-METHOXYCHALCONE is used as a precursor in the synthesis of 3-(4-methoxy-phenyl)-3-morpholin-4-yl-1-phenyl-propan-1-one, a compound with potential pharmaceutical applications. The reaction involves the use of morpholine as a reactant and heptanes as a solvent, which allows for the formation of the desired product through a condensation process.
This application highlights the importance of 4'-METHOXYCHALCONE in the development of new drugs and therapeutic agents, as its reactivity and structural features can be exploited to create a wide range of bioactive molecules. By serving as a versatile precursor, 4'-METHOXYCHALCONE contributes to the advancement of pharmaceutical research and the discovery of innovative treatments for various diseases and conditions.

Upstream product

• 13677-45-7 1-(4-methoxyphenyl)-3-phenylprop-2-en-1-ol 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 100-51-6 benzyl alcohol 
• 3319-15-1 rac-1-(4-methoxyphenyl)-ethanol 
• 94-41-7 benzalacetophenone 
• 98-86-2 acetophenone 
• 3988-77-0 3-phenyl-1-thiophen-2-yl-propenone 
• 100-07-2 4-methoxy-benzoyl chloride 
• 536-74-3 phenylacetylene 
• 875877-84-2 [[1-(4-methoxyphenyl)-3-phenyl-2-propynyl]oxy]-trimethylsilane 
• 100-52-7 benzaldehyde 
• 6097-26-3 p-methoxyphenacyl thiocyanate 
• 7446-70-0 aluminium trichloride 
• 102-92-1 cinnamoyl chloride 

Downstream Products

• 186083-47-6 1,3-bis(4-methoxyphenyl)-3-phenylpropan-1-one 
• 500550-52-7 1-(4-methoxy-phenyl)-4-nitro-3,4-diphenyl-butan-1-one 
• 636987-22-9 (+/-)-1-(4-methoxyphenyl)-3-phenyl-pentan-1-one 
• 2657-24-1 1-(4-methoxyphenyl)-3,3-diphenylpropan-1-one 
• 171860-04-1 [3-(4-methoxy-phenyl)-3-oxo-1-phenyl-propyl]-malonic acid diethyl ester 
• 5739-38-8 1-(4-methoxyphenyl)-3-phenylpropan-1-one 
• 7145-87-1 2,3-dibromo-1-(4-methoxyphenyl)-3-phenylpropan-1-one 
• 20080-08-4 3-(4-methoxyphenyl)-5-phenyl-4,5-dihydroisoxazole 
• 201545-01-9 1-acetyl-3-(4-methoxyphenyl)-5-phenyl-4,5-dihydro-1H-pyrazole 
• 111505-36-3 1,6-bis-(4-methoxy-phenyl)-3,4-diphenyl-hexane-1,6-dione 
• 150356-89-1 2,3,6,8-tetrahydro-7-(4-methoxyphenyl)-5-phenyl-2-thioxopyrido<2,3-d>pyrimidin-4(1H)-one 
• 128721-58-4 7-(4-Methoxy-phenyl)-5-phenyl-2-thioxo-1,3-di-m-tolyl-1,2,3,5-tetrahydro-pyrano[2,3-d]pyrimidin-4-one 
• 128721-72-2 5-[3-(4-Methoxy-phenyl)-3-oxo-1-phenyl-propyl]-2-thioxo-1,3-di-m-tolyl-dihydro-pyrimidine-4,6-dione 
• 128721-71-1 5-[3-(4-Methoxy-phenyl)-3-oxo-1-phenyl-propyl]-2-thioxo-1,3-di-o-tolyl-dihydro-pyrimidine-4,6-dione 

Relevant articles and documents

New pyrimidine derivatives as efficient organic inhibitors on mild steel corrosion in acidic medium: Electrochemical, SEM, EDX, AFM and DFT studies

New pyrimidine derivatives, namely, 7-methoxypyrido [2,3-d]pyrimidin-4-amine (MPPA) and 4-amino-7-methoxypyrido[2,3-d]pyrimidin-2(1H)-one (AMPO) were synthesized and their inhibitive action against the corrosion of mild steel in 15% HCl solution was studi

Selective catalytic synthesis of α-alkylated ketones and β-disubstituted ketones via acceptorless dehydrogenative cross-coupling of alcohols

Herein, a phosphine-free pincer ruthenium(III) catalyzed β-alkylation of secondary alcohols with primary alcohols to α-alkylated ketones and two different secondary alcohols to β-branched ketones are reported. Notably, this transformation is environmentally benign and atom efficient with H2O and H2 gas as the only byproducts. The protocol is extended to gram-scale reaction and for functionalization of complex vitamin E and cholesterol derivatives.

Synthesis of chalcone derivatives by phthalhydrazide-functionalized tio2-coated nano-fe3o4 as a new heterogeneous catalyst

Phthalhydrazide immobilized on TiO2-coated nano Fe3O4 (Fe3O4-P) was synthesized and characterized by FT-IR, XRD, SEM, EDS and VSM analysis. The resulting magnetic nanocatalyst was used as a catalyst for the synthesis of chalcone derivatives which affords the desired products in good to excellent yields. This catalyst can be isolated readily after completion of the reaction by an external magnetite field and reused several times without significant loss of activity.