959-23-9

Basic information

• Product Name: 4'-METHOXYCHALCONE
• Synonyms: 4'-METHOXYCHALCONE;2-BENZYLIDENE-4'-METHOXYACETOPHENONE;1-(4-METHOXYPHENYL)-3-PHENYLPROP-2-EN-1-ONE;METHOXYCHALCONE, 4'-;(E)-1-(4-METHOXYPHENYL)-3-PHENYLPROP-2-EN-1-ONE;RARECHEM AM UC 0609;alpha-styryl p-anisyl ketone;4'-METHOXYCHALCONE 97%
• CAS NO: 959-23-9
• Molecular Formula: C₁₆H₁₄O₂
• Molecular Weight: 238.28
• EINECS: 213-495-5
• Product Categories: Chalcones;C15 to C38;Carbonyl Compounds;Ketones
• Mol File: 959-23-9.mol
• Article Data: 148

Chemical Properties

• Melting Point: 101-103 °C(lit.)
• Boiling Point: 397.5°Cat760mmHg
• Flash Point: 180.5°C
• Appearance: /
• Density: 1.114g/cm³
• Water Solubility: Soluble in dichloromethane and methanol. Insoluble in water.
• BRN: 644640
• CAS DataBase Reference: 4'-METHOXYCHALCONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-METHOXYCHALCONE(959-23-9)
• EPA Substance Registry System: 4'-METHOXYCHALCONE(959-23-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 959-23-9(Hazardous Substances Data)

Usage

Description

4'-METHOXYCHALCONE is an organic compound that serves as a key intermediate in the synthesis of various pharmaceuticals and chemical compounds. It is characterized by its unique structure, which includes a chalcone backbone with a methoxy group attached to the 4' position of the phenyl ring. This structural feature endows 4'-METHOXYCHALCONE with specific chemical properties and reactivity, making it a valuable building block in organic synthesis.

Uses

Used in Pharmaceutical Industry:
4'-METHOXYCHALCONE is used as a precursor in the synthesis of 3-(4-methoxy-phenyl)-3-morpholin-4-yl-1-phenyl-propan-1-one, a compound with potential pharmaceutical applications. The reaction involves the use of morpholine as a reactant and heptanes as a solvent, which allows for the formation of the desired product through a condensation process.
This application highlights the importance of 4'-METHOXYCHALCONE in the development of new drugs and therapeutic agents, as its reactivity and structural features can be exploited to create a wide range of bioactive molecules. By serving as a versatile precursor, 4'-METHOXYCHALCONE contributes to the advancement of pharmaceutical research and the discovery of innovative treatments for various diseases and conditions.

Upstream product

• 100-66-3 methoxybenzene 
• 621-82-9 Cinnamic acid 
• 100-42-5 styrene 
• 794-94-5 p-Methoxybenzoic anhydride 
• 111008-99-2 3-hydroxy-1-(4-methoxy-phenyl)-3-phenyl-propan-1-one 
• 123-11-5 4-methoxy-benzaldehyde 
• 98-86-2 acetophenone 
• 13677-45-7 1-(4-methoxyphenyl)-3-phenylprop-2-en-1-ol 
• 89530-34-7 1-phenyl-3-trimethylsilylprop-2-yn-1-ol 
• 459-64-3 4-methoxybenzenediazonium tetrafluoroborate 
• 3988-77-0 3-phenyl-1-thiophen-2-yl-propenone 
• 94-41-7 benzalacetophenone 
• 3319-15-1 rac-1-(4-methoxyphenyl)-ethanol 
• 100-51-6 benzyl alcohol 

Downstream Products

• 87544-66-9 3-(4-methoxybenzoyl)-4-phenyl-4,5-dihydropyrazole 
• 90054-42-5 3-(4-Methoxy-phenyl)-5-phenyl-1H-pyridazin-4-one 
• 50344-32-6 1-(p-Methoxyphenyl)-3-phenyl-3-(2'-oxocyclopentyl)-1-propanone 
• 271601-30-0 (S)-1-(4-Methoxy-phenyl)-3,5-diphenyl-pentane-1,5-dione 
• 89009-18-7 6-(4-Methoxy-phenyl)-3-methyl-2,4-diphenyl-pyridine 
• 79888-93-0 2-Methoxy-6-(4-methoxyphenyl)-3-methyl-2,4-diphenyl-2H-pyran 
• 76973-50-7 (RS)-3-(4-methoxyphenyl)-5-phenyl-4,5-dihydropyrazole-1-carbaldehyde 
• 91232-43-8 (E)-1-(4-Methoxy-phenyl)-5-(4-nitro-phenyl)-3-phenyl-pent-2-ene-1,5-dione 
• 56119-91-6 3-(4-methoxyphenyl)-1-methyl-5-phenyl-1H-pyrazole 
• 101456-32-0 3-<3'-(4''-methoxyphenyl)-3'-oxo-1'-phenylpropyl>isobenzofuran-1(3H)-one 
• 2348-77-8 2-phenyl[1,4]naphthoquinone 
• 30069-65-9 3-phenylnaphthalen-1-ol 
• 77565-59-4 5-(4-methoxyphenyl)-5-oxo-3-phenylpentanoic acid 

Relevant articles and documents

New pyrimidine derivatives as efficient organic inhibitors on mild steel corrosion in acidic medium: Electrochemical, SEM, EDX, AFM and DFT studies

New pyrimidine derivatives, namely, 7-methoxypyrido [2,3-d]pyrimidin-4-amine (MPPA) and 4-amino-7-methoxypyrido[2,3-d]pyrimidin-2(1H)-one (AMPO) were synthesized and their inhibitive action against the corrosion of mild steel in 15% HCl solution was studi

Synthesis of lithium/cesium-Zagronas from zagrosian natural asphalt and study of their activity as novel, green, heterogeneous and homogeneous nanocatalysts in the Claisen–Schmidt and Knoevenagel condensations

A novel, heterogeneous and homogeneous basic nanocatalysts were synthesized by grafting of lithium and cesium on zagrosian natural asphalt sulfonate (Li/Cs-Zagronas). The activity of these catalysts was examined in the Claisen–Schmidt and Knoevenagel condensations under mild reaction conditions. Li/Cs-Zagronas were characterized by FT-IR spectroscopy, scanning electron microscopy, X-ray diffraction, energy-dispersive spectroscopy, inductively coupled plasma and thermogravimetric analysis techniques. These nanocatalysts were removed by simple filtration and reused several times without any deterioration of activity.

Activated charcoal-mediated synthesis of chalcones catalyzed by NaOH in water

A variety of chalcones were synthesized in good yields by the activated charcoal-mediated aldol reactions between benzaldehydes and acetophenones catalyzed by NaOH in water. 2,6-Bis((E)-benzylidene)cyclohexan-1-ones were prepared by the aldol reactions between benzaldehydes and cyclohexanone. Activated charcoal could be recycled five times without the significant decrease of yields.