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2-AMINO-1-BUTANOL is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

96-20-8

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96-20-8 Usage

Chemical Properties

clear liquid

Uses

Different sources of media describe the Uses of 96-20-8 differently. You can refer to the following data:
1. Emulsifying agent (in soap form) for oils, fats, and waxes; absorbent for acidic gases; organic syn- thesis.
2. These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Check Digit Verification of cas no

The CAS Registry Mumber 96-20-8 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 9 and 6 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 96-20:
(4*9)+(3*6)+(2*2)+(1*0)=58
58 % 10 = 8
So 96-20-8 is a valid CAS Registry Number.
InChI:InChI=1/C4H11NO/c1-2-4(5)3-6/h4,6H,2-3,5H2,1H3/p+1/t4-/m1/s1

96-20-8 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (B24398)  (±)-2-Amino-1-butanol, 97%   

  • 96-20-8

  • 100ml

  • 291.0CNY

  • Detail
  • Alfa Aesar

  • (B24398)  (±)-2-Amino-1-butanol, 97%   

  • 96-20-8

  • 500ml

  • 1012.0CNY

  • Detail
  • Sigma-Aldrich

  • (PHR1501)  Aminobutanol  pharmaceutical secondary standard; traceable to USP

  • 96-20-8

  • PHR1501-1G

  • 1,293.67CNY

  • Detail
  • USP

  • (1020008)  Aminobutanol  United States Pharmacopeia (USP) Reference Standard

  • 96-20-8

  • 1020008-500MG

  • 11,588.85CNY

  • Detail
  • Aldrich

  • (A43804)  2-Amino-1-butanol  97%

  • 96-20-8

  • A43804-100ML

  • 469.17CNY

  • Detail
  • Aldrich

  • (A43804)  2-Amino-1-butanol  97%

  • 96-20-8

  • A43804-500ML

  • 1,577.16CNY

  • Detail

96-20-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Amino-1-Butanol

1.2 Other means of identification

Product number -
Other names 2-Aminobutanol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:96-20-8 SDS

96-20-8Relevant articles and documents

CONTINUOUS FLOW PROCESS AND APPARATUS FOR MANUFACTURE OF DL-2-NITRO-1-BUTANOL

-

Paragraph 0035-0040, (2021/02/12)

A continuous process(200) for manufacture of dl-2-nitro-1-butanol from 1-nitropropane is disclosed. The process mixes aqueous solution of sodium hydroxide (A) and a solution of 1-nitropropane (B) dissolved in alcohol(203) at a first molar ratio in a first tubular reactor to form a mixture. The mixture is pumped(205) with an aqueous solution of formaldehyde at a second predetermined molar ratio to a second tubular reactor for a second residence time to form a product stream. The product stream is quenched(207) in glacial acetic acid to obtain quench liquor having dl-2-nitro-1-butanol. The first(130) and the second(150) tubular reactors are maintained at a temperature of 35° C or less. The method produces conversion of at least 89% dl-2-nitro-1-butanol with residence time of 30 minutes or less. Apparatus for continuous production of dl-2-nitro-1-butanol from 1-nitropropane is further disclosed. A method of obtaining dl-2-amino-1-butanol by hydrogenation of the dl-2-nitro-1-butanol is further disclosed.

Development of an engineered thermostable amine dehydrogenase for the synthesis of structurally diverse chiral amines

Chen, Fei-Fei,Chen, Qi,Liu, Lei,Wang, Dong-Hao,Wang, Zhi-Long,Xu, Jian-He,Zhang, Zhi-Jun,Zheng, Gao-Wei

, p. 2353 - 2358 (2020/05/13)

Amine dehydrogenases (AmDHs) are emerging as a class of attractive biocatalysts for synthesizing chiral amines via asymmetric reductive amination of ketones with inexpensive ammonia as an amino donor. However, the AmDHs developed to date exhibit limited substrate scope. Here, using directed evolution, we engineered a GkAmDH based on a thermostable phenylalanine dehydrogenase from Geobacillus kaustophilus. The newly developed AmDH is able to catalyze reductive amination of a diverse set of ketones and functionalized hydroxy ketones with ammonia or primary amines with up to >99% conversion, thus accessing structurally diverse chiral primary and secondary amines and chiral vicinal amino alcohols, with excellent enantioselectivity (up to >99% ee) and releasing water as the sole by-product.

Borohydride reduction stabilizing system and method for reducing ester into alcohol

-

Paragraph 0110; 0111; 0112, (2019/09/13)

The invention provides a borohydride reduction stabilizing system and a method for reducing ester into alcohol. The borohydride reduction stabilizing system comprises a borohydride reducing agent anda stabilizer for stabilizing the borohydride reducing agent, wherein the borohydride reducing agent is sodium borohydride or potassium borohydride, and the stabilizer is an alkali metal salt of alcohol. On the basis of an existing sodium borohydride/potassium reducing agent, an alcohol alkali metal salt (such as sodium alcoholate or potassium alcoholate) is added, and then the sodium borohydride/potassium reducing agent can keep stable and is not decomposed under a heating condition, so that on one hand, reduction activity is maintained in a relatively high state and the situation of excessiveuse is reduced, and on the other hand, generation of hydrogen is reduced and the process risk is reduced.

Rapid and Quantitative Profiling of Substrate Specificity of ω-Transaminases for Ketones

Han, Sang-Woo,Shin, Jong-Shik

, p. 3287 - 3295 (2019/06/21)

ω-Transaminases (ω-TAs) have gained growing attention owing to their capability for asymmetric synthesis of chiral amines from ketones. Reliable high-throughput activity assay of ω-TAs is essential in carrying out extensive substrate profiling and establishing a robust screening platform. Here we report spectrophotometric and colorimetric methods enabling rapid quantitation of ω-TA activities toward ketones in a 96-well microplate format. The assay methods employ benzylamine, a reactive amino donor for ω-TAs, as a cosubstrate and exploit aldehyde dehydrogenase (ALDH) as a reporter enzyme, leading to formation of benzaldehyde detectable by ALDH owing to concomitant NADH generation. Spectrophotometric substrate profiling of two wild-type ω-TAs of opposite stereoselectivity was carried out at 340 nm with 22 ketones, revealing subtle differences in substrate specificities that were consistent with docking simulation results obtained with cognate amines. Colorimetric readout for naked eye detection of the ω-TA activity was also demonstrated by supplementing the assay mixture with color-developing reagents whose color reaction could be quantified at 580 nm. The colorimetric assay was applied to substrate profiling of an engineered ω-TA for 24 ketones, leading to rapid identification of reactive ketones. The ALDH-based assay is expected to be promising for high-throughput screening of enzyme collections and mutant libraries to fish out the best ω-TA candidate as well as to tailor enzyme properties for efficient amination of a target ketone.

NITROGENOUS HETEROCYCLIC COMPOUND, PREPARATION METHOD, INTERMEDIATE, COMPOSITION AND USE

-

Paragraph 0532, (2019/01/17)

Disclosed are a nitrogenous heterocyclic compound, intermediates, a preparation method, a composition and use thereof. The nitrogenous heterocyclic compound in the present invention is as shown in formula I. The compound has a high inhibitory activity towards ErbB2 tyrosine kinase and a relatively good inhibitory activity towards human breast cancer BT-474 and human gastric cancer cell NCI-N87 which express ErbB2 at a high level, and at the same time has a relatively weak inhibitory activity towards EGFR kinase. Namely, the compound is a highly selective small-molecule inhibitor targeted at ErbB2, and hence it has a high degree of safety, and can effectively enlarge the safety window in the process of taking the drug.

The hydrolysis of epoxides catalyzed by inorganic ammonium salts in water: Kinetic evidence for hydrogen bond catalysis

Nozière,Fache,Maxut,Fenet,Baudouin,Fine,Ferronato

, p. 1583 - 1590 (2018/02/06)

Naturally-occurring inorganic ammonium ions have been recently reported as efficient catalysts for some organic reactions in water, which contributes to the understanding of the chemistry in some natural environments (soils, seawater, atmospheric aerosols, .) and biological systems, and is also potentially interesting for green chemistry as many of their salts are cheap and non-toxic. In this work, the effect of NH4+ ions on the hydrolysis of small epoxides in water was studied kinetically. The presence of NH4+ increased the hydrolysis rate by a factor of 6 to 25 compared to pure water and these catalytic effects were shown not to result from other ions, counter-ions or from acid or base catalysis, general or specific. The small amounts of amino alcohols produced in the reactions were identified as the actual catalysts by obtaining a strong acceleration of the reactions when adding these compounds directly to the epoxides in water. Replacing the amino alcohols by other strong hydrogen-bond donors, such as trifluoroethanol (TFE) or hexafluoroisopropanol (HFIP) gave the same results, demonstrating that the kinetics of these reactions was driven by hydrogen-bond catalysis. Because of the presence of many hydrogen-bond donors in natural environments (for instance amines and hydroxy-containing compounds), hydrogen-bond catalysis is likely to contribute to many reaction rates in these environments.

O -Phthalaldehyde catalyzed hydrolysis of organophosphinic amides and other P(O)-NH containing compounds

Li, Bin-Jie,Simard, Ryan D.,Beauchemin, André M.

supporting information, p. 8667 - 8670 (2017/08/10)

Over 50 years ago, Jencks and Gilchrist showed that formaldehyde catalyses the hydrolysis of phosphoramidate through electrophilic activation, induced by covalent attachment to its nitrogen atom. Given our interest in the use of aldehydes as catalysts, this work was revisited to identify a superior catalyst, o-phthalaldehyde, which facilitates hydrolyses of various organophosphorus compounds bearing P(O)-NH subunits under mild conditions. Interestingly, chemoselective hydrolysis of the P(O)-N bonds could be accomplished in the presence of P(O)-OR bonds.

Highly efficient and diastereoselective synthesis of 1,3-oxazolidines featuring a palladium-catalyzed cyclization reaction of 2-butene-1,4-diol derivatives and imines

Chen, Dongxu,Chen, Xiaoyi,Du, Taiping,Kong, Lichun,Zhen, Renwei,Zhen, Shaocheng,Wen, Yihang,Zhu, Gangguo

supporting information; experimental part, p. 5131 - 5133 (2010/11/18)

A palladium-catalyzed protocol for effective synthesis of 1,3-oxazolidines has been reported. This method is featured by the high diastereoselectivity (dr up to >98/2) and using the readily available 2-butene-1,4-diol derivatives and imines as substrates.

New, convenient methods of synthesis and resolution of 1,2-amino alcohols

Periasamy, Mariappan,Sivakumar, Sangarappan,Reddy, Meda Narsi

, p. 1965 - 1967 (2007/10/03)

Oximes of α-keto esters are reduced to obtain the corresponding amino alcohols using NaBH4 in combination with I2, CH 3COOH, TiCl4, ZrCl4, COCl2, H 2SO4, and TMS-Cl in 60-85% yields. The racemic phenylglycinol, phenylalaninol, and 2-aminobutanol are resolved using dibenzoyl-L-tartaric acid to obtain enantiomeric samples of >98% ee.

Cardiac tropism radiopharmaceutical products incorporating a nitride complex of a transition metal and having a rapid myocardial clearance

-

, (2008/06/13)

The present invention relates to cardiac tropism radiopharmaceutical products incorporating a nitride complex os a transition metal and having a rapid myocardial clearance. PAL These complexes are based on the formula: EQU (MN)L1 L2 (I) PAL in which M is a transition metal such as 99m Tc and L1 and L2 comply with the formula: STR1 in which at least one of the R and R' represents a branched alkyl group having one or more ether functions, a tetrahydrofurfuryl or ether group, a tetrahydrofurfuryl or dioxaspiro or dialkoxy piperidino groups.

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