96304-42-6

Basic information

• Product Name: trypanothione
• Synonyms: Trypanothione trifluoroacetate salt;trypanothione disulfide
• CAS NO: 96304-42-6
• Molecular Formula: C27H47N9O10S2
• Molecular Weight: 721.853
• Product Categories: amino
• Mol File: 96304-42-6.mol

Chemical Properties

• Boiling Point: 1284.7 °C at 760 mmHg
• Flash Point: 730.8 °C
• Appearance: /
• Density: 1.41 g/cm³
• Storage Temp.: Store at 0°C
• BRN: 3645155
• CAS DataBase Reference: trypanothione(CAS DataBase Reference)
• NIST Chemistry Reference: trypanothione(96304-42-6)
• EPA Substance Registry System: trypanothione(96304-42-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 96304-42-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Trypanothione is used as a target for drug development for treating trypanosomiasis and Chagas disease. Its involvement in the defense against oxidative stress and its presence in trypanosomatid parasites make it an attractive target for the design of new therapeutic agents. Inhibiting trypanothione metabolism or function can lead to the death of the parasites and provide a potential treatment for these diseases.
Used in Research Applications:
Trypanothione is used as a research tool to study the biology and pathogenesis of trypanosomatid parasites. Understanding the role of trypanothione in these organisms can help researchers develop new strategies for combating these diseases and provide insights into the unique metabolic pathways of these parasites.
Used in Drug Discovery:
Trypanothione is used as a starting point for the development of new drugs targeting trypanosomiasis and Chagas disease. By studying the structure and function of trypanothione and its associated enzymes, researchers can identify potential drug candidates that can disrupt the redox balance in trypanosomatid parasites, leading to their death and providing a potential cure for the diseases.

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Relevant articles and documents

Solid phase applications of Dde and the analogue Nde: Synthesis of trypanothione disulphide

Bis - Dde and Nde spermidine derivatives selectively protected on the primary amines were readily prepared and attached via the secondary amine group to a p-nitrophenyl-1-chloroformate pre-activated HMPA resin. Deprotection for Nde was monitored by colour

5-Substituted 3-chlorokenpaullone derivatives are potent inhibitors of Trypanosoma brucei bloodstream forms

Trypanothione synthetase is an essential enzyme for kinetoplastid parasites which cause highly disabling and fatal diseases in humans and animals. Inspired by the observation that N(5)-substituted paullones inhibit the trypanothione synthetase from the related parasite Leishmania infantum, we designed and synthesized a series of new derivatives. Although none of the new compounds displayed strong inhibition of Trypanosoma brucei trypanothione synthetase, several of them caused a remarkable growth inhibition of cultivated Trypanosoma brucei bloodstream forms. The most potent congener 3a showed antitrypanosomal activity in double digit nanomolar concentrations and a selectivity index of three orders of magnitude versus murine macrophage cells.

Solid phase synthesis of polyamine conjugates for the study of trypanothione reductase

A number of polyamine scaffolds were synthesised, enabling the facile preparation of a variety of polyamine conjugates using both Boc and Fmoc protecting group strategies. Products were released from the solid support by treatment with either triflic acid/trifluoroacetic acid or trifluoroacetic acid. The trypanosomal metabolite N1, N6-bis(glurathionyl)spermidine [trypanothione], and a range of related analogues were prepared for biological evaluation as previously communicated.

Synthesis and NMR Characterization of the Trypanosomatid Metabolite, N1,N8-Bis(glutathionyl)spermidine Disulphide (Trypanothione Disulphide)

An optimized chemical synthesis of the novel trypanosomatid metabolite, N1,N8-bis(glutathionyl)spermidine (trypanothione disulphide) is described, and its solution structure has been investigated by NMR spectroscopy.The 1H, 13C, and

Synthesis of the Trypanosomatid Metabolites Trypanothione, and N1-Mono- and N8-Mono-glutathionylspermidine

The trypanosomatid metabolite trypanothione 1,N8-bis(glutathionyl)spermidine> and its biosynthetic co-metabolites the isomeric N1- and N8-mono-glutathionylspermidines have been synthesised by a mild route whic