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| CAS No.: | 4091-50-3 |
|---|---|
| Name: | [2-(4-METHOXY-PHENYL)-ETHYL]-METHYL-AMINE |
| Molecular Structure: | |
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| Formula: | C10H15 N O |
| Molecular Weight: | 165.235 |
| Synonyms: | Phenethylamine,p-methoxy-N-methyl- (6CI,8CI); (p-Methoxyphenethyl)methylamine;4-Methoxy-N-methylbenzeneethanamine; 4-Methoxy-N-methylphenethylamine;N-(p-Methoxyphenethyl)methylamine; N-Methyl-(p-methoxyphenethyl)amine;N-Methyl-2-(4-methoxyphenyl)ethylamine; N-Methyl-4-methoxy-b-phenethylamine;N-Methyl-4-methoxyphenethylamine; N-Methyl-N-(4-methoxyphenethyl)amine; N-Methyl-b-(4-methoxyphenyl)ethylamine;[2-(4-Methoxyphenyl)ethyl]methylamine; p-Methoxy-N-methylphenethylamine |
| Density: | 0.963g/cm3 |
| Boiling Point: | 251.2°Cat760mmHg |
| Flash Point: | 99.3°C |
| Safety: | Poison by intravenous route. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also AMINES. |
| PSA: | 21.26000 |
| LogP: | 1.84800 |
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- 136390-01-7
ethyl-N-<2-(4-methoxyphenyl)ethyl>-carbamate
- 4091-50-3
N-methylhomoanisylamine
| Conditions | Yield |
|---|---|
| With lithium aluminium tetrahydride In tetrahydrofuran Heating; | 99% |
| With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 50℃; Inert atmosphere; | 27% |
- 91247-71-1
2-4-methoxyphenylethylcarbamic acid methyl ester
- 4091-50-3
N-methylhomoanisylamine
| Conditions | Yield |
|---|---|
| With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; Reflux; | 93% |
| With lithium aluminium tetrahydride |
| Conditions | Yield |
|---|---|
| In methanol for 168h; Ambient temperature; | 73% |
| Stage #1: methylamine; 1-(2-Chloroethyl)-4-methoxybenzene In ethanol at 20℃; for 1h; Stage #2: With triisobutylaluminum In ethanol at 60℃; for 24h; | 72% |
- 74-89-5
methylamine
- 768-60-5
4-methoxyphenylacetylen
A
- 4091-50-3
N-methylhomoanisylamine
B
- 41684-13-3
4-methoxy-N-methyl-α-methylbenzylamine
| Conditions | Yield |
|---|---|
| Stage #1: methylamine; 4-methoxyphenylacetylen; Ind2TiMe2 In toluene at 80℃; under 760 Torr; for 7h; Stage #2: With sodium cyanoborohydride; zinc(II) chloride In methanol; toluene at 25℃; for 16h; | A 20% B 19% |
| Conditions | Yield |
|---|---|
| anschliessend mit Dimethylsulfat und dann mit wss. Aethanol; |
| Conditions | Yield |
|---|---|
| With methanol at 100℃; |
- 59907-36-7
2-(4-methoxyphenyl)-N-methylacetamide
- 4091-50-3
N-methylhomoanisylamine
| Conditions | Yield |
|---|---|
| With lithium aluminium tetrahydride In tetrahydrofuran | |
| With borane-THF In tetrahydrofuran for 4h; Inert atmosphere; Reflux; |
- 56100-69-7
N-[2-(4-methoxyphenyl)ethyl]formamide
- 4091-50-3
N-methylhomoanisylamine
| Conditions | Yield |
|---|---|
| With lithium aluminium tetrahydride In tetrahydrofuran |
| Conditions | Yield |
|---|---|
| With 4-methyl-morpholine; lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; Wang resin 1.) 0 deg C, 2 h; room temp., overnight, 2.) DMF, room temp., overnight, 3.) THF, 60 deg C, 14 h; Yield given. Multistep reaction; |
- 13139-86-1
4-methoxyphenyl magnesium bromide
- 4091-50-3
N-methylhomoanisylamine
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Chemistry
Product Name: Compound 48/80 (CAS NO.4091-50-3)
Molecular Formula: C10H15NO
Molecular Weight: 165.23g/mol
Mol File: 4091-50-3.mol
Boiling point: 251.2 °C at 760 mmHg
Storage Temperature:
Flash Point: 99.3 °C
Density: 0.963 g/cm3
Surface Tension: 32 dyne/cm
Enthalpy of Vaporization: 48.85 kJ/mol
Vapour Pressure: 0.0208 mmHg at 25°C
XLogP3-AA: 1.7
H-Bond Donor: 1
H-Bond Acceptor: 2
Product Categories: Amines and Anilines
Uses
Compound 48/80 (CAS NO.4091-50-3) promotes histamine release. In biochemical research, compound 48/80 is used to promote mast cell degranulation.
Production
Compound 48/80 (CAS NO.4091-50-3) is a polymer produced by the condensation of N-methyl-p-methoxyphenethylamine with formaldehyde.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | intravenous | 1290ug/kg (1.29mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 120, Pg. 353, 1959. |
| mouse | LD50 | intravenous | 1950ug/kg (1.95mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 120, Pg. 353, 1959. |
| rabbit | LD50 | intravenous | 1500ug/kg (1.5mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 120, Pg. 353, 1959. |
| rat | LD50 | intravenous | 2400ug/kg (2.4mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 120, Pg. 353, 1959. |
Safety Profile
Poison by intravenous route. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also AMINES.
Specification
Compound 48/80 ,its CAS NO. is 4091-50-3,the synonyms is 4-Methoxy-n-methyl-benzeneethanamin ; p-Methoxy-n-methyl-phenethylamin ; [2-(4-Methoxy-phenyl)-ethyl]-methyl-amine ; p-Methoxy-n-methylphenethylamine ; n-Methyl 4-methoxyphenethylamine ; 2-(4-Methoxyphenyl)-n-methylethanamine ; 4-Methoxy-n-methylbenzeneethanamine ; n-Methyl-2-(4-methoxyphenyl)ethylamine .