- Norfloxacin
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is a kind of fluorinated quinolone antibacterial. This chemical is a kind of antibiotic which can be used in the treatment of upper respiratory tract infection, urinary tract, gastrointestinal system for bacterial infections, biliary, surgery, obstetrics and gynaecology infection. There are some basic informations about this crude drug: (1)CAS No:; (2)Molecular Formula: C16H18FN3O3; (3)Molecular Weight: 319.33; (4)EINECS: 274-614-4; (5)Melting Point: 220 °C; (6)Boiling Point: 555.8 °C at 760 mmHg; (7)Flash Point: 289.9 °C; (8)Density: 1.344 g/cm3.
Norfloxacin is a synthetic chemotherapeutic agent occasionally used to treat common as well as complicated urinary tract infections.
In the adult population Oral and I.V. Norfloxacin is limited to the treatment of proven bacterial infections. The initial approval by the U.S. Food and Drug Administration (FDA) in 1986 encompassed the following indications:
Uncomplicated urinary tract infections (including cystitis)
Complicated urinary tract infections (restricted use)
Uncomplicated urethral and cervical gonorrhea (however this indication is no longer considered to be effective by some experts due to bacterial resistance)
Prostatitis due to Escherichia coli.
Syphilis treatment: Norfloxacin has not been shown to be effective in the treatment of syphilis. Antimicrobial agents used in high doses for short periods of time to treat gonorrhea may mask or delay the symptoms of incubating syphilis.
Though the fluoroquinolones are sometimes used to treat typhoid and paratyphoid fever, it should be noted here that norfloxacin had more clinical failures than the other fluoroquinolones.In ophthalmology, Norfloxacin licensed use is limited to the treatment of conjunctival infections caused by susceptible bacteria. Norfloxacin has been restricted in the Republic of Ireland due to the risks of C difficile super infections and permanent nerve as well as tendon injuries. It licensed use in acute and chronic complicated kidney infections has been withdrawn as a result.
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