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 Succinic Acid: A New Platform Chemical for Biobased Polymers
  • Succinic Acid: A New Platform Chemical for Biobased Polymers
  • Succinic Acid: A New Platform Chemical for Biobased Polymers from Renewable Resources

    is predicted to be one of the future platform chemicals that can be derived from renewable resources. The improvements in biotechnological succinic acid production are presented. Chemical conversion pathways to -butyrolactone, tetrahydrofuran, 1,4-butanediole, and pyrrolidones are reviewed. An overview of possible new biopolymers (e. g. polyesters, polyamides, and poly(ester amide)s) based on succinic acid and its derivatives is given. Nevertheless, industrial processes using purified succinic acid from fermentation broths are not state of the art yet. Further improvements are needed until succinic acid-based chemical production will be economically favorable.

    An efficient succinic acid production process in a metabolically engineered Corynebacterium glutamicum strain

    A Corynebacterium glutamicum strain (Δ ldhA -pCRA717) that overexpresses the pyc gene encoding pyruvate carboxylase while simultaneously exhibiting a disrupted ldhA gene encoding l -lactate dehydrogenase was investigated in detail for succinic acid production. Succinic acid was shown to be efficiently produced at high-cell density under oxygen deprivation with intermittent addition of sodium bicarbonate and glucose. Succinic acid concentration reached 1.2402M (14602g l 611 ) within 4602h. The yields of succinic acid and acetic acid from glucose were 1.4002mol mol 611 (0.9202g g 611 ) and 0.2902mol mol 611 (0.1002g g 611 ), respectively. The succinic acid production rate and yield depended on medium bicarbonate concentration rather than glucose concentration. Consumption of bicarbonate accompanied with succinic acid production implied that added bicarbonate was used for succinic acid synthesis.

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