Chemical Reaction - Basic Chemical -
Acyloin Condensation
Acyloin Condensation
L. Bouveault, R. Loquin, Compt. Rend. 140, 1593 (1905).
Reductive coupling of esters by sodium to yield acyloins (α-hydroxyke Acetoacetic Ester Synthesis
Acetoacetic Ester Synthesis
Base-catalyzed alkylation or arylation of β-ketoesters. Subsequent mild hydrolysis and decarboxylation yield substituted acetones. Alterna Claisen Condensation
Claisen Condensation (Acetoacetic Ester Condensation)
L. Claisen, O. Lowman, Ber. 20, 651 (1887).
Base-catalyzed condensation of an ester containing an Ugi Reaction
Ugi Reaction (Four-Component Condensation, 4CC)
I. Ugi, Angew. Chem. Int. Ed. 1, 8 (1962).
The α-addition of an iminium ion and the conjugate base
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