Houben-Fischer Synthesis

J. Houben, W. Fischer, J. Prakt. Chem. [2] 123, 89, 262, 313 (1929).

Formation of aromatic nitriles by basic hydrolysis of trichloromethyl aryl ketimines. Acidic hydrolysis yields ketones:



J. Houben, W. Fischer, Ber. 63, 2464 (1930); 64, 240, 2636, 2645 (1931); 66, 339 (1933); D. T. Mowry, Chem. Rev. 42, 221 (1948); P. E. Spoerri, A. S. DuBois, Org. React. 5, 390 (1949); G. Hesse, Houben-Weyl 4/2 103 (1955); W. Ruske in Friedel-Crafts and Related Reactions vol. III, Part 1, G. A. Olah, Ed. (Interscience, New York, 1964) p 407. Cf. Houben-Hoesch Reaction.