Rosenmund Reduction

K. W. Rosenmund, Ber. 51, 585 (1918); K. W. Rosenmund, F. Zetzsche, ibid. 54, 425 (1921).

Catalytic reduction of acid chlorides to aldehydes. To prevent further hydrogenation a poison is added to the catalyst:



Reviews: E. Mosettig, R. Mozingo, Org. React. 4, 362 (1948); A. Rachlin et al., Org. Syn. 51, 8 (1971); J. A. Peters, H. Van Bekkum, Rec. Trav. Chim. 100, 21 (1981). Investigation of reaction parameters: W. F. Maier et al., J. Am. Chem. Soc. 108, 2608 (1986). Modified procedure applied to the synthesis of esters: V. V. Grushin, H. Alper, J. Org. Chem. 56, 5159 (1991).