- Strecker Amino Acid Synthesis
-
Strecker Amino Acid Synthesis
A. Strecker, Ann. 75, 27 (1850); 91, 349 (1854).
Synthesis of α-amino acids by reaction of aldehydes with ammonia and hydrogen cyanide followed by hydrolysis of the resulting α-aminonitriles. Safer, milder, and more selective reaction conditions have been developed, especially in regard to asymmetric synthesis. The scope of the reaction has been extended to include primary and secondary amines:
Reviews: J. P. Greenstein, M. Winitz, Chemistry of the Amino Acids vol. 3 (New York, 1961) pp 698-700; G. C. Barrett, Chemistry and Biochemistry of the Amino Acids (Chapman and Hall, New York, 1985) pp 251, 261. Asymmetric synthesis using enantiopure sulfinimines: F. A. Davis et al., Tetrahedron Letters 35, 9351 (1994); idem et al., J. Org. Chem. 61, 440 (1996). Asymmetric syntheses: M. S. Sigman, E. N. Jacobsen, J. Am. Chem. Soc. 120, 4901 (1998); E. J. Corey, M. J. Grogan, Organic Letters 1, 157 (1999). Review of stereoselective synthesis: R. O. Duthaler, Tetrahedron 50, 1539-1650 (1994); T. K. Chakraborty et al., ibid. 51, 9179-9190 (1995). Cf. Bucherer-Bergs Reaction.
Prev: Strecker Degradation
Next: Stork Enamine Reaction - 【Back】【Close 】【Print】【Add to favorite 】
- Related information
- Market Quotations of Adipic Acid on January 12th
- Market Quotations of Adipic Acid on January 11th
- International Priceso of Synthesis Ammonia in the Falling Trends
- Market Quotations of Adipic Acid on January 10th
- Market Quotations of Adipic Acid on January 9th
- Market Quotations of Adipic Acid on January 4th
- Prices of Sulfuric Acid Continues Its Falling Trends
- Market Quotations of Adipic Acid on December 31th
- Market Quotations of Adipic Acid on December 30th
- Market Quotations of Adipic Acid on December 28th
-
Health and Chemical more >
-
Hot Products
- 69422-57-7 1-chloro-2-(chloromethyl)-4-nitrobenzene
- 5002-47-1 Decanoic acid,2-[4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazinyl]ethylester
- 91598-91-3 Acetamide, N-(6-hydroxy-1-pyrenyl)-
- 170810-05-6 1H-Benzotriazole, 3a,4,5,6,7,7a-hexahydro-4(or 5)-methyl-
- 74853-08-0 1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine
- 3685-84-5 Meclofenoxate hydrochloride
- 554-68-7 Triethylamine hydrochloride
- 22260-51-1 Bromocriptine mesylate
- 3140-73-6 1,3,5-Triazine,2-chloro-4,6-dimethoxy-
- 28940-11-6 Watermelon Ketone
- 26672-24-2 2-(4-AMINO-2,5-DIMETHOXY-PHENYL-SULFONYL)ETHANOL SULFATE ESTER
- 302-95-4 Cholan-24-oic acid,3,12-dihydroxy-, monosodium salt, (3a,5b,12a)-