- Synthesis of Ketorolac
-
(CAS NO.: ), with its systematic name of 1H-Pyrrolizine-1-carboxylic acid, 2,3-dihydro-5-benzoyl-, (+-)-, could be produced through many synthetic methods.
Following is one of the reaction routes:

2-Methylthiopyrrole (I) is benzoylated with N,N-dimethylbenzamide (II) to produce 5-benzoyl-2-methylthiopyrrole (III) in the presence of POCl3 in refluxing CH2Cl2, and the yielding product is condensed with spiro[2.5]-5,7-dioxa-6,6-dimethyloctane-4,8-dione (IV) in the presence of NaH in DMF giving compound (V). The oxidation of (V) with m-chloroperbenzoic acid in CH2Cl2 affords the sulfone (VI), which is submitted to methanolysis with methanol and HCl giving 1-(3,3-dimethoxycarbonylpropyl)-2-methanesulfonyl-5-benzoylpyrrole (VII). The cyclization of (VII) with NaH in DMF yields dimethyl 5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1,1-dicarboxylate (VIII), which is finally hydrolyzed and decarboxylated with KOH in refluxing methanol.Compound (III) can be oxidized with m-chloroperbenzoic acid as before giving 2-methanesulfonyl-5-benzoylpyrrole (IX), which is then condensed with spiro compound (IV) as before to afford compound (VI), already obtained.
Prev:No record
Next:No record - 【Back】【Close 】【Print】【Add to favorite 】
-
Health and Chemical more >
-
Hot Products
- 12765-62-7 Nipastat
- 14745-75-6 stearic acid, compound with N,N-dimethyloctadecylamine (1:1)
- 139163-20-5 Vipsogal
- 41593-38-8 PROPYLENEGLYCOLPHENYLETHER
- 879765-63-6 3-(2,4-dimethoxyphenyl)-1H-pyrazole-5-carboxylic acid
- 90295-11-7 Copper, [29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32]-, aminosulfonyl sulfo derivs., sodium salts
- 143-28-2 9-Octadecen-1-ol, (9Z)-
- 106685-41-0 Mehtyl 6-[3-(1-adamanty)-4-methoxy phenyl]-2-naphthoate
- 58957-92-9 Idarubicin
- 219861-08-2 Escitalopram oxalate
- 1314-20-1 Thorium oxide
- 66032-51-7 1,4-Benzenedicarboxylic acid, bis(2,3-dihydroxypropyl) ester


