(CAS NO.: ), with its systematic name of 2H-, 1,3-dihydro-5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-, could be produced through many synthetic methods.

Following is one of the synthesis routes: 1-(3-Chloropropyl)-2-benzimidazolinone (I) is condensed with 5-chloro-1-(piperidin-4-yl)-2-benzimidazolinone (II) in the presence of Na₂CO₃ and KI in 4-methyl-2-pentanone to produce Domperidone.