Zotepine (CAS NO.: ), with other name of 8-Chloro-10-(2-dimethylaminoethoxy)dibenzo[b,f]thiepine, could be produced through many synthetic methods.

Following are two of the synthesis routes:

1). By condensation of 8-chlorodibenzo[b,f]thiepin-10(11H)-one (I) with 2-dimethylaminoethyl chloride (II) in the presence of NaH in benzene - DMF at 60 C.
2). By condensation of 8-chloro-10-(2-chloroethoxy)dibenzo[b,f]thiepin (III) with dimethylamine.