- Synthesis of Fluconazole
-
(CAS NO.: ), with its systematic name of 1H--1-ethanol, alpha-(2,4-difluorophenyl)-alpha-(1H-1,2,4-triazol-1-ylmethyl)-, could be produced through many synthetic methods.
Following is one of the synthesis routes: The Friedel-Crafts condensation of 1,3-di (I) with chloroacetyl chloride (II) by means of AlCl3 yields alpha-chloro-2,4-difluoroacetophenone (III), which is treated with 1,2,4- (IV) and triethylamine in refluxing ethyl acetate giving alpha-(1H-12,4-triazol-1-yl)-2,4-diftuoroacetophenone (V). The reaction of (V) with trimethylsulfoxonium iodide (VI) by means of NaOH in toluene affords 1-[2-(2,4-di fluorophenyl)-2,3-epoxypropyl]- (VII), which is finally treated again with 1,2,4-triazole (IV) and K2CO3 in hot DMF.

Prev:No record
Next:No record - 【Back】【Close 】【Print】【Add to favorite 】
-
Health and Chemical more >
-
Hot Products
- 152459-95-5 Imatinib
- 149313-99-5 Formaldehyde, polymerswith sulfonated bis(1-methylethyl)naphthalene and sulfonated1,1'-oxybis[methylbenzene], ammonium salts
- 4422-95-1 1,3,5-Benzenetricarboxylic acid chloride
- 610-14-0 2-Nitrobenzoyl chloride
- 946-33-8 2-BENZYLCYCLOHEXANONE
- 138245-74-6 6-AZIDO-6-DEOXY-D-GALACTITOL
- 17420-30-3 5-Nitroanthranilonitrile
- 50-23-7 Hydrocortisone
- 10476-85-4 Strontium chloride
- 25736-86-1 POLY(ETHYLENE GLYCOL) (N) MONOMETHACRYLATE
- 33368-86-4 Decanoic acid, 2-[(1-oxooctyl)oxy]-1,3-propanediyl ester
- 68698-70-4 Phenol, 4,4-(1-methylethylidene)bis-, polymer with (chloromethyl)oxirane, N,N-diethyl-1,3-propanediamine and 1-piperazineethanamine


