linoleate (CAS NO.: ), with other name of 9alpha-Fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione-21-(octadeca-cis-9,cis-12-dienoate), could be produced through many synthetic methods.

Following is one of the synthesis routes: Dexamethasone alcohol (I) could react with methanesulfonyl chloride to produce dexamethasone mesylate (II), and then the yielding compound is transesterified with potassium linoleate in dimethylformamide to produce the final product.