- Production of Minoxidil
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(CAS NO.: ), with its systematic name of 2,4-diamine, 6-(1-piperidinyl)-, 3-oxide, could be produced through many synthetic methods.
Following are two of the synthesis routes:
1). The oxidation of (I) with m-chloroperbenzoic acid in alcohol gives 6-amino-4-chloro-1,2-dihydro-1-hydroxy-2-iminopyrimidine (II), which is then condensed with refluxing piperidine.
2). A mixture of (I), 2,4-dichlorophenol (A) and KOH was heated at 150 C to give 2,4-diamino-6-(2,4-dichlorophenoxy)pyrimidine (III), which is oxidized with m-chloroperbenzoic acid in alcohol giving 6-amino-4-(2,4-dichlorophenoxy)-1,2-dihydro-1-hydroxy-2-iminopyrimidine (IV). Finally, this product is treated with piperidine at 150 C.


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