Bulaquine (CAS NO.: 79781-00-3), with its systematic name of 2(3H)-Furanone, dihydro-3-(1-((4-((6-methoxy-8-quinolinyl)amino)pentyl)amino)ethylidene)-, could be produced through many synthetic methods.

Following is one of the synthesis routes: The title enamine derivative is prepared by condensation of primaquine (I) with acetyl butyrolactone (II) by means of piperidine.