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 Purification of Isopropyl ether
  • Purification of Isopropyl ether
  • Common impurities of (CAS NO. ) are water and peroxides [detected by the liberation of iodine from weakly acid (HCl) solns of 2% KI]. Peroxides can be removed by shaking with aqueous Na2SO3 or with acidified ferrous sulfate (0.6g FeSO4 and 6mL conc H2SO4 in 110mL of water, using 5-10g of soln per L of ether), or aqueous NaBH4 soln. The ether is then washed with water, dried with CaCl2 and distd. Alternatively, refluxing with LiAlH4 or CaH2, or drying with CaSO4, then passage through an activated alumina column, can be used to remove water and peroxides. Other dehydrating agents used with isopropyl ether include P2O5, sodium amalgam and sodium wire. (The ether is often stored in brown bottles, or in the dark, with sodium wire.) Bonner and Goishi treated isopropyl ether with dil sodium dichromate/sulfuric acid soln, followed by repeated shaking with a 1:1 mixture of 6M NaOH and saturated KMnO4. The ether was washed several times with water, dilute aqueous HCl, and water, with a final washing with, and storage over, ferrous ammonium sulfate acidified with H2SO4. Blaustein and Gryder, after washing with alkaline KMnO4, then water, treated the ether with ceric nitrate in nitric acid, and again washed with water. was added before drying with CaCl2 and MgSO4, and refluxing with sodium amalgam (108g Hg/100g Na) for 2h under nitrogen. The distillate (nitrogen atmosphere) was made 2x10-5 M in hydroquinone to inhibit peroxide formation (which was negligible if the ether was stored in the dark). (pyrocatechol) and resorcinol are alternative inhibitors.


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