- Synthesis of 2-(2-Methoxyphenyl)-2-methylpropionitrile
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2-(2-Methoxyphenyl)-2-methylpropionitrile (CAS NO.: 13524-75-9), which is known as acetonitrile, 2-methoxy-α,α-dimethyl-, could be produced through the following synthetic route.
2-(2-Methoxyphenyl)-2-methylpropionitrile (CAS NO.: 13524-75-9). A 300-mL, three-necked, round-bottomed flask equipped with a reflux condenser and a -coated magnetic stir bar is placed under a nitrogen atmosphere and charged with 2-fluoroanisole (10.00 g, 79.28 mmol), 100 mL of tetrahydrofuran (THF) and potassium hexamethyldisilylamide (KHMDS, 23.72 g, 118.92 mmol). Isobutyronitrile (28.8 mL, 316.71 mmol) is added via syringe. The reaction mixture is heated to 60°C for 23 hr. After the solution is cooled to room temperature, it is transferred to a 1000-mL separatory funnel containing 300 mL of methyl tert-butyl ether and 300 mL of 1 N hydrochloric acid (HCl). The organic layer is separated and washed successively with 300 mL of water and 200 mL of brine. The organic phase is dried over anhydrous magnesium sulfate (MgSO4), filtered, and concentrated to provide the desired product as a tan oil (13.75 g, 99%).
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