- Reaction routes of Metronidazole
-
(CAS NO.: ), with its chemical name of 2-Methyl-5-nitro--1-ethanol, could be produced through the following several reaction routes.
1). Preparation method one:
The title compound can also be obtained by alkylation, in different solvents, of 1-(acetoxymethyl)-2-methyl-4-nitro (I) with either ethylene sulfate (II) or with bis-(2-acetoxyethyl) sulfate (III) -generated from ethyleneglycol diacetate (IV) and either dimethyl sulfate or H2SO4 - followed by hydrolysis or alcoholysis treatment.2). Preparation method two:
(I) is converted into the bisulfate salt, and then nitrated by means of a sulfonitric mixture in Ac2O to produce 2-methyl-4-nitroimidazole (II) . In a variant of this procedure, 2-methylimidazole (I) is nitrated by using a ferric nitrate-tonsyl adduct in several solvents. Imidazole (II) is then regioselectively alkylated with boiling 2-chloroethanol to produce the title compound. Alternatively, the alkylation of (II) has been reported by treatment with ethylene oxide (III) under acidic conditions.
Prev:No record
Next:No record - 【Back】【Close 】【Print】【Add to favorite 】
- Related information
-
Health and Chemical more >
-
Hot Products
- 128-49-4 Butanedioic acid,2-sulfo-, 1,4-bis(2-ethylhexyl) ester, calcium salt (2:1)
- 13877-91-3 OCIMENE
- 34338-96-0 (2S,5S)-(+)-Hexanediol
- 20056-66-0 3-PENTYL-PHENOL
- 7580-67-8 Lithium hydride (LiH)
- 1744-22-5 2-Benzothiazolamine,6-(trifluoromethoxy)-
- 110683-22-2 8-Amino-4-oxo-2-(tetrazol-5-yl)-4H-1-benzopyran
- 104-75-6 2-Ethylhexylamine
- 122334-95-6 2-Propenoic acid, 2-methyl-, 3-(trimethoxysilyl)propyl ester, reaction products with vitreous silica
- 522-48-5 Tetrahydrozoline hydrochloride
- 723-46-6 Sulfamethoxazole
- 7758-09-0 Potassium nitrite