Sparfosic acid (CAS NO.: ), with other name of N-(Phosphonoacetyl)-L-aspartate, could be produced through the following synthetic routes.

The reaction routes are going on as below:

1) The reaction of phophonoacetic acid (I) with SOCl₂ at 50 C gives phosphonoacetyl chloride (II), which is condensed with diethyl aspartate (III) by means of NaOH in water affording diethyl (phosphonoacetyl)-L-aspartate (IV). Finally, this compound is hydrolyzed with LiOH or NaOH in water. 2) Compound (I) can be esterified with ethanol and dry HCl giving ethyl phosphonoacetate (V), which by reaction with hydrazine is converted into phosphonoacetyl hydrazide (VI). Finally, this compound is condensed with (III) by means of NaNO₂ and HCl in DMF-water to afford (IV).