- Synthesis of Nabumetone
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(CAS NO.: ), with systematic name of , 4-(6-methoxy-2-naphthalenyl)-, could be produced through many synthetic methods.
One of the reaction routes is as below:
The condensation of 6-methoxy- (I) with ethyl aceto-acetate (II) gives ethyl 2-(6-methoxy-2-naphthylmethylene)acetoacetate (III), which is reduced to ethyl 2-(6-methoxy-2-naphthylmethyl)acetoacetate (IV). Finally, this compound is hydrolyzed and decarboxylated in acidic medium.
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