- Production Method of Piperidine, 4-(p-aminophenoxy)-1-methyl-4-phenyl-
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, 4-(p-aminophenoxy)-1-methyl-4-phenyl- (CAS NO.: ), with other name of Benzenamine, 4-((1-methyl-4-phenyl-4-piperidinyl)oxy)-, could be produced through many synthetic methods.
Following is one of the reaction routes:
Reaction of 1-methyl-4-piperidone (I) with phenyllithium (II) gives 1-methyl-4-phenyl-4-piperidinol (III), which is alkylated with (IV) in NaH/DMF to yield (V), followed by reduction with hydrazine/Raney-Ni.
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