(CAS NO.: ), with other names like , 2-amino-4-nitro-, could be produced through the following synthetic methods.

In a 5-l. three-necked flask, suspended over a steam bath, are placed 300 g. (1.63 moles) of technical 2,4-dinitrophenol and 2.5 l. of water. The flask is fitted with an efficient stirrer, a reflux condenser, and a thermometer which dips below the surface of the mixture. After the stirrer has been started, 600 g. (11.6 moles) of ammonium chloride and 100 ml. of concentrated aqueous ammonia (about 28%) are added, and the mixture is heated to 85°. The steam is turned off, and the mixture is allowed to cool. When the temperature reaches 70°, 700 g. (5.4 moles) of 60% fused sodium sulfide is added in portions of about 100 g. at 5-minute intervals. After two or three such additions the temperature of the reaction mixture reaches 80–85°; it is kept in this range either by adding the remaining portions of sodium sulfide at 10-minute intervals or by wrapping the flask with a wet cloth and continuing the additions at 5-minute intervals. After all the sodium sulfide has been added, the reaction mixture is heated at 85° for 15 minutes and then filtered through a heated 6-in. Büchner funnel.

The hot filtrate is transferred to a 5-l. round-bottomed flask and cooled overnight by a stream of cold water. The mixture is filtered, and the crystals are pressed nearly dry. The solid is dissolved in 1.5 l. of boiling water, and the solution is acidified with glacial acetic acid (about 100 ml. is required). The solution is heated with 10 g. of Norit, filtered hot, and cooled to 20°. The brown crystals are collected and dried for several hours in an oven at 65° or in a vacuum desiccator. The yield of 2-amino-4-nitrophenol melting at 140–142° is 160–167 g. (64–67%). If a purer product is desired, the crude substance is recrystallized from 1.5 l. of hot water; 147–153 g. (58–61%) of material melting at 142–143° is obtained.