Indometacin farnesil (CAS NO.: ), with other name of 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid 3,7,11-trimethyl-2,6,10-dodecatrienyl ester, could be produced through many synthetic methods.

Following is one of the reaction routes: The reacion of 1-(4-chlorobenzoyl)-2-methyl-5-methoxyindolyl-3-acetic acid (I) with SOCl₂ in refluxing benzene gives the corresponding acyl chloride (II), which is condensed with farnesol (III) by means of triethylamine in THF.