- Production Method of Racecadotril
-
Racecadotril (CAS NO.: 81110-73-8), with its systematic name of Glycine, N-(2-((acetylthio)methyl)-1-oxo-3-phenylpropyl)-, phenylmethyl ester, (+-)-, could be produced through many synthetic methods.
Following is one of the synthesis routes: 2-Benzylacrylic acid (I) reacts with SOCl2 in hot toluene to afford the acyl chloride (II), which is condensed with N-tosylglycine benzyl ester (III) in the presence of TEA in toluene to yield the corresponding amide (IV). Finally, this compound is condensed with thioacetic acid by heating at 80 °C to afford the target acylthio compound.
Prev:No record
Next:No record - 【Back】【Close 】【Print】【Add to favorite 】
-
Health and Chemical more >
-
Hot Products
- 27848-84-6 Ergoline-8-methanol,10-methoxy-1,6-dimethyl-, 8-(5-bromo-3-pyridinecarboxylate), (8b)-
- 38436-16-7 (1H,1H,2H,2H-PERFLUORO-N-HEXYL)METHYLDICHLORO-SILANE
- 886497-54-7 2,3-Dichloro-6-fluorophenylacetonitrile
- 78675-95-3 4-fluoro-N-(pyridin-3-ylmethyl)aniline
- 577-11-7 Butanedioicacid, 2-sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt (1:1)
- 7758-80-7 Monosodium phosphate
- 74-84-0 Ethane
- 790661-41-5 2-Thiazolidinethione, 3-acetyl-4-(phenylmethyl)-, (4S)-
- 12410-14-9 iron chloride sulphate
- 461-82-5 4-(Trifluoromethoxy)aniline
- 25655-35-0 POLYBUTADIENE ADDUCTED WITH MALEIC ANHYDRIDE
- 594-58-1 2-chloro-2-methylpropionic acid