RP-67580 (CAS NO.: 135911-02-3), with its systematic name of 4H-Isoindol-4-one, octahydro-2-(1-imino-2-(2-methoxyphenyl)ethyl)-7,7-diphenyl-, (3aR-cis)-, could be produced through many synthetic methods.

Following is one of the synthesis routes:
 

4,4-Diphenyl-2-cyclohexen-1-one (I) is cyclized with N-benzyl-N-(butoxymethyl)-N-(trimethylsilylmethyl)amine (II) to produce 2-benzyl-7,7-diphenylperhydroisoindol-4-one (III), which is debenzylated by hydrogenation with H₂ over Pd/C to afford 7,7-diphenylperhydroisoindol-4-one (IV). The optical resolution of (IV) yields the desired enantiomer, which is finally condensed with 2-(2-methoxyphenyl)acetimidic acid ethyl ester tetrafluoroborate (V).