Hot Products

Basic Information

Post buying leads

Suppliers

Cas Database

Name	Cinchonine	EINECS	204-234-6
CAS No.	118-10-5	Density	1.2 g/cm³
PSA	36.36000	LogP	3.10250
Solubility	insoluble in water	Melting Point	256-266 °C
Formula	C₁₉H₂₂N₂O	Boiling Point	464.5 °C at 760 mmHg
Molecular Weight	294.396	Flash Point	234.7 °C
Transport Information	N/A	Appearance	white to light yellow crystal powder
Safety	26-36-36/37	Risk Codes	20/21/22
Molecular Structure		Hazard Symbols	Xn
Synonyms	(S)-[(5R,7R)-5-ethenyl-1-azabicyclo[2.2.2]oct-7-yl]-quinolin-4-yl-methanol;Quinoline alkaloid;.alpha.-Quinidine;Prestwick_501;(9S)-Cinchonan-9-ol;(S)-[(4R,5S,7S)-5-ethenyl-1-azoniabicyclo[2.2.2]oct-7-yl]-quinolin-4-yl-methanol;[(5S,7R)-5-ethenyl-1-azabicyclo[2.2.2]oct-7-yl]-quinolin-4-yl-methanol;D-Cinchonine;Cinchonan-9-ol, (9S)-;2-Quinuclidinemethanol, .alpha.-(5-vinyl-2-quinolyl)-;4-quinolyl(5-vinyl-1-azabicyclo[2.2.2]oct-2-yl)methanol;(+)-Cinconine;	Article Data	21

Cinchonine Synthetic route

: 189309-24-8
O-tosylcinchonine

A: 1393446-38-2
(Z)-1-(quinolin-4-yl)-3-((3R,4R)-3-vinylpiperidin-4-yl)prop-1-enyl 4-methylbenzene sulfonate

B: 118-10-5
Cinchonin

C: 118-10-5, 485-70-1, 485-71-2, 550-54-9, 40134-63-2, 72402-55-2, 72402-56-3
(+)-cinchonine

Conditions

Conditions	Yield
With salicylic acid In ethylene glycol at 95℃; for 0.5h; Microwave irradiation;	A 60% B 15% C 15%

: 560119-43-9
methanesulfonic acid (quinolin-4-yl)(5-vinyl-1-azabicyclo[2.2.2]oct-2-yl)methyl ester

A: 118-10-5
Cinchonin

B: 118-10-5, 485-70-1, 485-71-2, 550-54-9, 40134-63-2, 72402-55-2, 72402-56-3
(+)-cinchonine

C: 560119-45-1
(1S,2R,3S,5S,6R)-2-(quinolin-4-yl)-6-vinyl-1-azabicyclo[3.2.2]nonan-3-ol

D: (E)-cinchene

Conditions

Conditions	Yield
With water; tartaric acid at 100℃; Title compound not separated from byproducts;	A n/a B n/a C 48% D 1%

: 14509-68-3, 14528-54-2, 72402-48-3, 72402-49-4
cinchonan-9-one

: 64-19-7
acetic acid

iron powder: iron powder

: 118-10-5
Cinchonin

: 14509-68-3, 14528-54-2, 72402-48-3, 72402-49-4
cinchonan-9-one

: 64-17-5
ethanol

sodium: sodium

: 118-10-5
Cinchonin

: 14402-57-4
benzoylcinchonine

alcoholic KOH-solution: alcoholic KOH-solution

A: 65-85-0
benzoic acid

B: 118-10-5
Cinchonin

Conditions

Conditions	Yield
at 60 - 70℃;

: (9S,10Ξ)-10-iodo-10,11-dihydro-cinchonan-9-ol; dihydriodide hydrate

water: water

A: 118-10-5
Cinchonin

B: 7299-23-2
9,10-Epoxy-10,11-dihydro-cinchonan

C apocinchonine: apocinchonine

Conditions

Conditions	Yield
at 150 - 160℃; im Rohr; isomer(ic) I;

: 118-10-5
Cinchonin

: 1609-86-5
Tert-butyl isocyanate

: (9S)-9-deoxy-cinchonin-9-yl tert-butylcarbamate

Conditions

Conditions	Yield
With dibutyltin(II) dilaurate In toluene at 110℃; for 48h;	99%

: 917-54-4
methyllithium

: 118-10-5
Cinchonin

: 2'-methylcinchonine

Conditions

Conditions	Yield
In tetrahydrofuran at -10 - 50℃; for 6h; Inert atmosphere; Schlenk technique;	99%
In tetrahydrofuran at -78.16℃; for 12h; Inert atmosphere;

: 24463-19-2
anthracenylmethyl chloride

: 118-10-5
Cinchonin

: (2R,5R,1'S)-1-(9-anthracenyl)methyl-5-ethylene-2-[1-hydroxy-1-(quinol-4-yl)]methyl-1-azoniabicyclo[2.2.2]octane chloride

Conditions

Conditions	Yield
In toluene at 110℃; for 2h;	98%
In toluene Reflux;	94%
In toluene for 24h; Heating;	80%

: (1E,4E)-1,5-bis(4-(bromomethyl)phenyl)penta-1,4-dien-3-one

: 118-10-5
Cinchonin

: C57H60N4O3(2+)*2Br(1-)

Conditions

Conditions	Yield
In tetrahydrofuran; N,N-dimethyl-formamide Reflux;	98%

Cinchonine Chemical Properties

The molecular formula of Cinchonine(118-10-5) is C₁₉H₂₂N₂O and its formula weight is 294.39.
Cinchonine(118-10-5) has a melting point of 260-263 °C.
The chemical synonyms of Cinchonine(118-10-5) are D-CINCHONINE;(+)-CINCHONINE;CINCHONINE;CINCHONAN-9-OL,(9S)-;(+)-cinconine;(8r,9s)-cinchonine;(9s)-cinchonan-9-o;(9S)-Cinchonan-9-ol
The molecular structure of Cinchonine(118-10-5):

Cinchonine Toxicity Data With Reference

1.	ipr-rat LD50:152 mg/kg	APTOA6 Acta Pharmacologica et Toxicologica. 4 (1948),265.
2.	scu-mus LDLo:400 mg/kg	AEPPAE Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 205 (1948),129.
3.	scu-frg LDLo:200 mg/kg	AEPPAE Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 205 (1948),129.

Cinchonine Consensus Reports

Reported in EPA TSCA Inventory.

Cinchonine Safety Profile

Poison by intraperitoneal and subcutaneous routes. When heated to decomposition it emits toxic fumes of NO_x.
Hazard Codes Xn
Risk Statements 20/22-20/21/22
Safety Statements 26-36-36/37
RIDADR 1544
WGK Germany 3
RTECS GD3500000
F 8-34
HazardClass 6.1(b)
PackingGroup III

Cinchonine Specification

Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Incompatible materials, light.
Incompatibilities with Other Materials Strong oxidizing agents, strong reducing agents, strong bases.
Hazardous Decomposition Products Nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide.
Hazardous Polymerization Has not been reported.

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 118-10-5