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Conditions | Yield |
---|---|
With acetyl chloride for 2.5h; Heating; | 100% |
Stage #1: methanol; D-Serine With acetyl chloride at 0℃; Stage #2: In methanol for 3h; Heating; | 100% |
With hydrogenchloride In water at 55℃; | 100% |
methanol
D-Serine
acetyl chloride
R-(-)-serine methyl ester hydrochloride
Conditions | Yield |
---|---|
Stage #1: methanol; acetyl chloride for 0.0833333h; Cooling with ice; Stage #2: D-Serine for 2h; Reflux; | 97% |
Conditions | Yield |
---|---|
In methanol for 15.5h; Reflux; | 91% |
R-(-)-serine methyl ester hydrochloride
benzyl chloroformate
(R)-methyl 2-(((benzyloxy)carbonyl)amino)-3-hydroxypropanoate
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In water; ethyl acetate at 20℃; Cooling with ice; | 100% |
With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 12h; | 91% |
With sodium hydrogencarbonate | 80% |
di-tert-butyl dicarbonate
R-(-)-serine methyl ester hydrochloride
2-(tert-butoxycarbonylamino)-3-hydroxypropionic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: R-(-)-serine methyl ester hydrochloride With triethylamine In dichloromethane for 0.5h; Cooling with ice; Stage #2: di-tert-butyl dicarbonate In dichloromethane at 20℃; for 16.5h; Cooling with ice; | 100% |
With triethylamine In tetrahydrofuran at 0 - 140℃; for 0.333333h; Inert atmosphere; Microwave irradiation; | 99% |
With triethylamine In tetrahydrofuran at 0 - 50℃; for 17h; Inert atmosphere; | 97% |
bis(trichloromethyl) carbonate
R-(-)-serine methyl ester hydrochloride
(R)-2-oxo-oxazolidine-4-carboxylic acid methyl ester
Conditions | Yield |
---|---|
In tetrahydrofuran for 4h; Heating; | 100% |
In tetrahydrofuran for 4h; Reflux; Inert atmosphere; | 98% |
In tetrahydrofuran at 0 - 80℃; for 2h; | 75% |
trityl chloride
R-(-)-serine methyl ester hydrochloride
(2R)-3-hydroxy-2-(tritylamino)propanoic acid methyl ester
Conditions | Yield |
---|---|
With triethylamine In chloroform at 0℃; for 1h; | 99% |
With triethylamine In 1,2-dichloro-ethane at 50℃; for 12h; | 97% |
With triethylamine In dichloromethane at 0 - 25℃; for 16h; | 95% |
R-(-)-serine methyl ester hydrochloride
benzaldehyde
methyl (2R)-2-(benzylamino)-3-hydroxypropanoate
Conditions | Yield |
---|---|
Stage #1: R-(-)-serine methyl ester hydrochloride; benzaldehyde With magnesium sulfate; triethylamine In dichloromethane at 20℃; for 24h; Stage #2: With sodium tetrahydroborate In methanol at 0℃; for 3h; Further stages.; | 99% |
Stage #1: R-(-)-serine methyl ester hydrochloride With triethylamine In methanol at 0℃; for 0.25h; Inert atmosphere; Stage #2: benzaldehyde In methanol at 20℃; for 2h; Inert atmosphere; Stage #3: With sodium tetrahydroborate In methanol at 0℃; Inert atmosphere; | 99% |
Stage #1: R-(-)-serine methyl ester hydrochloride; benzaldehyde With triethylamine Stage #2: With sodium tetrahydroborate | 79% |
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide
R-(-)-serine methyl ester hydrochloride
2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxypropionic acid methyl ester
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In 1,4-dioxane; water cooling; | 99% |
With sodium hydrogencarbonate In 1,4-dioxane; water at 0 - 20℃; for 4.33333h; | 95% |
Conditions | Yield |
---|---|
With triethylamine In chloroform at 0 - 20℃; Inert atmosphere; | 99% |
Molecular Structure of D-Serine methyl ester hydrochloride (CAS NO.5874-57-7):
The Molecular formula of D-Serine methyl ester hydrochloride (CAS NO.5874-57-7): C4H10ClNO3
The Molecular Weight of D-Serine methyl ester hydrochloride (CAS NO.5874-57-7): 155.58
IUPAC Name: (E)-2-cyano-3-(1-phenyl-3-thiophen-2-ylpyrazol-4-yl)prop-2-enamide
H bond acceptors: 4
H bond donors: 3
Freely Rotating Bonds: 5
Polar Surface Area: 38.77Å2
Melting point: 163-166 °C(lit.)
Boiling Point: 234.7 °C at 760 mmHg
Flash Point: 95.8 °C
Enthalpy of Vaporization: 54.8 kJ/mol
Vapour Pressure: 0.00953 mmHg at 25°C
Appearance: White Solid
Storage temp: -15°C
Product Categories: Amino Acids series; Amino Acids; Amino Acids and Derivatives; All Aliphatics; Amino hydrochloride; Aliphatics; Amino Acids & Derivatives; Amino Acid Derivatives; Peptide Synthesis; Serine
The Hazard Codes of D-Serine methyl ester hydrochloride (CAS NO.5874-57-7): Xi
The Risk Statements information of D-Serine methyl ester hydrochloride (CAS NO.5874-57-7):
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information of D-Serine methyl ester hydrochloride (CAS NO.5874-57-7):
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
WGK Germany: 3
D-Serine methyl ester hydrochloride , with CAS number of 5874-57-7, can be called (R)-2-Amino-3-hydroxypropionic acid methyl ester hydrochloride ; (R)-Methyl 2-amino-3-hydroxypropanoate hydrochloride ; Methyl D-serinatehydrochloride ; DL-Serine, methyl ester, hydrochloride ; L-Serine, methyl ester, hydrochloride ; L-serine, methyl ester, hydrochloride (1:1) ; Methyl L-serinate hydrochloride (1:1) . It is a white solid.