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Conditions | Yield |
---|---|
In neat (no solvent) at 100℃; for 0.138833h; Solvent; Arbuzov Reaction; Flow reactor; | 99% |
for 1h; Irradiation; | 95% |
for 0.0833333h; Michaelis-Arbuzov reaction; microwave irradiation; | 95% |
Conditions | Yield |
---|---|
With iodine for 24h; Heating; | 99% |
With trimethylsilyl trifluoromethanesulfonate In chloroform at 60℃; for 18h; Michaelis-Arbuzov rearrangement; | 98% |
With trimethylsilyl iodide at 50℃; for 6h; Michaelis-Arbuzov rearrangement; | 95% |
1,1,1-tri(hydroxymethyl)propane
phosphorous acid trimethyl ester
dimethyl methane phosphonate
Conditions | Yield |
---|---|
Stage #1: 1,1,1-tri(hydroxymethyl)propane; phosphorous acid trimethyl ester at 80 - 120℃; for 4h; Stage #2: With methyl p-toluene sulfonate at 170 - 180℃; for 2h; Reagent/catalyst; Temperature; | 96% |
Conditions | Yield |
---|---|
With aluminum oxide at 20℃; | 95% |
With triethylamine | 80% |
benzyl bromide
phosphorous acid trimethyl ester
A
dimethyl benzylphosphonate
B
dimethyl methane phosphonate
Conditions | Yield |
---|---|
at 120℃; for 9h; | A 95% B 144 g |
phosphorous acid trimethyl ester
1-Bromo-2-bromomethyl-benzene
A
dimethyl (2-bromobenzyl)phosphonate
B
dimethyl methane phosphonate
Conditions | Yield |
---|---|
A 93% B n/a |
Conditions | Yield |
---|---|
at 100 - 140℃; for 0.2h; Arbuzov reaction; | A n/a B 90% |
Conditions | Yield |
---|---|
With tetrachlorosilane at 0℃; | 89% |
With p-TsOH-Celite at 20℃; | 87% |
Stage #1: methylphosphonic acid With 1H-imidazole; iodine In dichloromethane at 45 - 50℃; for 0.5h; Gareg-Samuelsson reaction; Stage #2: methanol In dichloromethane at 45 - 50℃; for 0.666667h; Gareg-Samuelsson reaction; | 85% |
1,2,2,2-tetrachloro-1-isocyanato-ethane
phosphorous acid trimethyl ester
A
2,2-dichloro-1-(dimethoxyphosphinyl)vinyl isocyanate
B
2,2,2-trichloro-1-(dimethoxyphosphinyl)ethyl isocyanate
C
dimethyl methane phosphonate
Conditions | Yield |
---|---|
at 100℃; for 1h; | A 7% B n/a C 81% |
phosphorous acid trimethyl ester
Benzyl bromoacetate
A
benzyl 2-(dimethoxyphosphoryl)acetate
B
dimethyl methane phosphonate
Conditions | Yield |
---|---|
at 85℃; for 60h; | A 81% B n/a |
1. | dlt-mus-orl 65 g/kg/13W-C | MUREAV Mutation Research. 138 (1984),213. | ||
2. | cyt-ham:ovr 250 mg/L | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD-A124-785 . | ||
3. | orl-mus TDLo:33 g/kg (female 7-14D post):REP | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) PB85-220143 . | ||
4. | orl-rat LD50:8210 mg/kg | TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxics Substances, 401M Street SW, Washington, DC 20460) FYI-OTS-0483-0242 . | ||
5. | ivn-rat LD50:1050 mg/kg | TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxics Substances, 401M Street SW, Washington, DC 20460) FYI-OTS-0483-0242 . | ||
6. | orl-mus LD50:>6810 mg/kg | NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No. NTP-TR-323 ,1987. | ||
7. | ivn-mus LD50:912 mg/kg | TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxics Substances, 401M Street SW, Washington, DC 20460) FYI-OTS-0483-0242 . |