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| CAS No.: | 121-45-9 |
|---|---|
| Name: | Trimethyl phosphite |
| Article Data: | 66 |
| Molecular Structure: | |
|
|
|
| Formula: | C3H9O3P |
| Molecular Weight: | 124.076 |
| Synonyms: | Fosforyn trojmetylowy;Trimethoxyfosfin;Trimethyl phosphite; |
| EINECS: | 204-471-5 |
| Density: | 1.052g/mLat 25°C(lit.) |
| Melting Point: | -78 °C |
| Boiling Point: | 110.2 °C at 760 mmHg |
| Flash Point: | 27.8 °C |
| Solubility: | Hydrolyzes with water. |
| Appearance: | clear colorless liquid |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 10-22-36/37/38 |
| Safety: | 26 |
| Transport Information: | UN 2329 3/PG 3 |
| PSA: | 41.28000 |
| LogP: | 1.15250 |
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- 67-56-1
methanol
- 139111-73-2
tris(4-dimethylaminopyridine)phosphorus(3+) bromide
A
- 84539-35-5
(3-bromopyridin-4-yl)-dimethyl-amine
B
- 121-45-9
phosphorous acid trimethyl ester
| Conditions | Yield |
|---|---|
| Inert atmosphere; | A n/a B 100% |
- 67-56-1
methanol
- 51145-42-7
4',4'-dimethyl-2λ5-spiro[benzo[1,3,2]dioxaphosphole-2,2'-[1,3,2]oxazaphospholidin]-5'-one
A
- 20570-25-6
2-methoxy-1,3,2-benzodioxaphosphole
B
- 121-45-9
phosphorous acid trimethyl ester
| Conditions | Yield |
|---|---|
| In N,N-dimethyl-formamide for 0.5h; Ambient temperature; | A 85% B 5% |
- 97688-35-2
(cyclopentadienyl)(iodomethyl)rhodium(P(OMe3)I
- 23936-60-9
1,2-bis(dimethylphosphanyl)ethane
A
- 84330-26-7
(cyclopentadienyl)(I)rhodium(dpme)(PF6)
B
- 121-45-9
phosphorous acid trimethyl ester
| Conditions | Yield |
|---|---|
| In benzene dropwise addn. of phosphine to Rh-compound in benzene (N2, Schlenk tube technique), stirring for 1h at room temp., filtn., washing with ether, drying in vac., dissolving in methanol, addn. of NH4PF6, stirring for 10 min; addn. of ether, filtn., washing with ether, recrystn. (acetone/ether); | A 83% B n/a |
| Conditions | Yield |
|---|---|
| With potassium phosphate; tetrahexylammonium chloride; phosphorus trichloride In dichloromethane at 20℃; for 3h; | 65% |
| With phosphorus trichloride Herstellung; | |
| With pyridine; phosphorus trichloride |
- 7175-47-5
4-methylphenyl isocyanide
B
- 603-35-0
triphenylphosphine
C
- 121-45-9
phosphorous acid trimethyl ester
| Conditions | Yield |
|---|---|
| In tetrahydrofuran byproducts: N2; addn. of the isocyanide to the Re compd. in THF and stirring for 2 h at room temp.; filtn., concn. (vac.), addn. of CH2Cl2 or THF, then Et2O, filtn., washing with Et2O and drying in vac.; | A 50% B n/a C n/a |
- 67-56-1
methanol
- 7051-21-0
2-methoxy-2,3-dihydro-1,3,2-benzoxazaphosphole
A
- 95-55-6
2-amino-phenol
B
- 67528-50-1, 16841-91-1
2',3'-dihydro-3H-2λ5-[2,2']spirobi(benzo[1,3,2]oxazaphosphole)
C
- 121-45-9
phosphorous acid trimethyl ester
| Conditions | Yield |
|---|---|
| A 17% B 24% C 15% |
- 67-56-1
methanol
- 80948-53-4
N1-methyl-N1-(2,3:5,6-di-O-isopropylidene-α-D-mannofuranosylamido)-N2,N3-tetraethyldiamidophosphite
A
- 80948-50-1, 80948-51-2
mixture of α- and β-2,3:5,6-di-O-isopropylidene-N-methyl-D-mannofuranosylamine
B
- 121-45-9
phosphorous acid trimethyl ester
| Conditions | Yield |
|---|---|
| at 20℃; for 3h; Product distribution; |
- 67-56-1
methanol
- 90213-29-9
α-methyllyxo-D-furanoside 2,3,5-bicyclophosphite
A
- 22416-73-5
methyl-α-D-lyxofuranoside
B
- 121-45-9
phosphorous acid trimethyl ester
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- Total:22 Page 1 of 1 1
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Specification
The Trimethyl phosphite, with its CAS registry number 121-45-9, is a kind of clear colorless liquid with a strong foul odor. This chemical is sensitive to air and moisture. It can also be named as fosforyntrojmetylowy;Methyl phosphite ((MeO)3P); P(OCH3)3; Phosphonousacidtrimethylester; Trimethoxyfosfin. As to its usage, it is widely applied in many ways. It could be used as the organic phosphorus pesticide intermediates, such as for the dichlorvos, phosphorous amines and monocrotophos; And it could also be used as flame retardants of plastic and wood, as well as catalyst of synthetic polymer and additive of painting.
Physical properties about Trimethyl phosphite are: (1)ACD/LogP: -0.797; (2)ACD/LogD (pH 5.5): -0.80; (3)ACD/LogD (pH 7.4): -0.80; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 8.78; (7)ACD/KOC (pH 7.4): 8.78; (8)#H bond acceptors:3; (9)#Freely Rotating Bonds: 3; (10)Flash Point: 27.778 °C; (11)Enthalpy of Vaporization: 33.446 kJ/mol; (12)Boiling Point: 110.229 °C at 760 mmHg; (13)Vapour Pressure: 28.1490001678467 mmHg at 25°C
Uses of Trimethyl phosphite: Trimethyl phosphite could react with chloro-triphenyl-methane to produce trityl-phosphonic acid dimethyl ester. This reaction could react in the temperature of 140 - 175 ℃.
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When you are dealing with this chemical, you should be very careful. For being a kind of harmful chemical, it may cause damage to health. And it is irritating to eyes, respiratory system and skin and it will be very dangerous if swallowed. Therefore, if in case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
(1)Canonical SMILES: COP(OC)OC
(2)InChI: InChI=1S/C3H9O3P/c1-4-7(5-2)6-3/h1-3H3
(3)InChIKey: CYTQBVOFDCPGCX-UHFFFAOYSA-N
The toxicity data is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LC | inhalation | > 32700mg/m3/6 (32700mg/m3) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | National Technical Information Service. Vol. OTS0537047, |
| mouse | LCLo | inhalation | 32700mg/m3/6H (32700mg/m3) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE | National Technical Information Service. Vol. OTS0537047, |
| mouse | LD50 | intraperitoneal | 4180mg/kg (4180mg/kg) | Environmental Research. Vol. 9, Pg. 1, 1975. | |
| mouse | LD50 | oral | 4280mg/kg (4280mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | National Technical Information Service. Vol. OTS0540442, |
| rabbit | LD50 | skin | 2600mg/kg (2600mg/kg) | American Industrial Hygiene Association Journal. Vol. 34, Pg. 286, 1973. | |
| rat | LCLo | inhalation | 32700mg/m3/6H (32700mg/m3) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE | National Technical Information Service. Vol. OTS0537047, |
| rat | LD50 | oral | 1600mg/kg (1600mg/kg) | Albright & Wilson Inc. Vol. #OPB-3, Pg. 1984, |