Synthesis p. 891 - 894 (1991)
Update date:2022-08-03
Topics:
Clark
Fischer
Schumacher
Racemic ethyl threo-3-14-methylthiophenyl)serinate is resolved by enzymatic hydrolysis using protease from Streptomyces griseus and both stereoisomers are converted to D-threo-4,5-dihydro-5-(4-methylsulfonylphenyl)-2-phenyl-4-oxazolemethan ol, thereby giving a formal synthesis of florfenicol.
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Doi:10.1039/b715810f
(2007)Doi:10.1016/j.tetasy.2007.10.042
(2007)Doi:10.1021/jm701175d
(2008)Doi:10.1002/adsc.201900693
(2019)Doi:10.1016/j.tetlet.2007.11.043
(2008)Doi:10.1007/BF00902385
(1959)
