Synthesis of the DE-ring of goniodomin A and prediction of its natural relative stereochemistry

Article abstract of DOI:10.1016/j.tetlet.2007.11.084

Goniodomin A (1) was first isolated from Alexandrium hiranoi as a stereochemically unidentified antifungal agent in 1987 by Murakami. In this study, two stereoisomeric series of non-macrocyclic and macrocyclic DE-ring model compounds of 1 were synthesized